The Qinghai-Tibetan Plateau (QTP), known as the “Third Pole of the Earth”, contains fragile ecosystems and is sensitive to global environmental changes. With the intensification of climate change and human activities, the land cover of the QTP is changing significantly, which affects its function as an ecological security barrier. This paper searched 379 papers in the Web of Science core database, conducted a bibliometric analysis, and proposed potential future research directions to gain a macroscopic understanding of the impact of land use and cover change (LUCC) on the regional and global ecological environment of the QTP. The results are as follows. (1) The period from 1995 to 2022 witnessed an overall increase in the number of publications in this field with a high development potential. (2) Climate change, land use, China, impacts, conservation, and management were high-frequency keywords in the field; among these, climate change has received increasing research attention since 2018. (3) The field included three main research directions: the impact of LUCC on biodiversity, the impact of land degradation on ecosystems, and the impact of climate change and land use changes on ecosystem services. (4) The development and evolution of research hotspots were mainly focused on three aspects: the impact of cultivated land expansion and deforestation, the impact of land use management and conservation, and the impact of climate change and human activities on LUCC. (5) Future research should focus on improving the accuracy of land use and cover data on the QTP, assessing and preventing the ecological risks of LUCC, investigating the impacts of human activities on LUCC and the ecological environment, and exploring the interactions between climate change and human activities on the ecological environment. The findings of this paper will help researchers and stakeholders gain a rapid and comprehensive understanding of this research area and thus contribute to the sustainable development of the QTP.