2012
DOI: 10.1016/j.jct.2011.09.026
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Study on the thermodynamics of the binding of iminium and alkanolamine forms of the anticancer agent sanguinarine to human serum albumin

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Cited by 49 publications
(27 citation statements)
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“…2 The therapeutic potential of chelerythrine in cancer research has also been well documented. 13 This has been very well demonstrated in the case of sanguinarine, 14 a close analogue of chelerythrine, which has been studied recently for its binding to lysozyme. [3][4][5][6][7] Recent studies have indicated that a PKC-independent mechanism may also be responsible for its potential anticancer properties.…”
Section: Introductionmentioning
confidence: 91%
“…2 The therapeutic potential of chelerythrine in cancer research has also been well documented. 13 This has been very well demonstrated in the case of sanguinarine, 14 a close analogue of chelerythrine, which has been studied recently for its binding to lysozyme. [3][4][5][6][7] Recent studies have indicated that a PKC-independent mechanism may also be responsible for its potential anticancer properties.…”
Section: Introductionmentioning
confidence: 91%
“…The instrument consists of a reference and a sample cell that holds a sample volume of 1.45 ml, while the syringe burette holds a volume of 282 μl. The titrations were carried out with sequential injections of the samples from the syringe burette into the sample cell with continuous mixing [42][43]. Different injection parameters can be controlled with the online software interface provided.…”
Section: Isothermal Titration Calorimetry (Itc)mentioning
confidence: 99%
“…It was observed that the binding constant between SMA and BSA was moderate, and for a given temperature the strength of SMA coupling to BSA was reduced with electrolyte concentration. Binding between the drug and protein may arise from different forces, namely hydrogen bonds, electrostatic, van der Waals, and hydrophobic interactions [26]. These factors contribute to the affinity constant and energetic of the binding process.…”
Section: Ionic Strength Influence On the Binding Between Sma And Bsamentioning
confidence: 99%