Study on the use of boromycin as a chiral selector in capillary electrophoresis

Maier, Vítězslav; Ranc, Václav; Švidrnoch, Martin; Petr, Jan; Ševčı́k, Juraj; Tesařová, Eva; Armstrong, Daniel W.

doi:10.1016/j.chroma.2012.02.073

Cited by 32 publications

(27 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since then, only three new articles describing the use of antibiotics in CE have been published. Among them, two describe the direct use of antibiotics in the BGE using NACE , and in the other, the antibiotic is linked to a filling forming a CSP which is used in CEC .…”

Section: Antibiotics As Chiral Selectors In Cementioning

confidence: 99%

Recent advances in CE analysis of antibiotics and its use as chiral selectors

et al. 2014

View full text Add to dashboard Cite

Antibiotics are a class of therapeutic molecules widely employed in both human and veterinary medicine. This article reviews the most recent advances in the analysis of antibiotics by CE in pharmaceutical, environmental, food, and biomedical fields. Emphasis is placed on the strategies to increase sensitivity as diverse off-line, in-line, and on-line preconcentration approaches and the use of different detection systems. The use of CE in the microchip format for the analysis of antibiotics is also reviewed in this article. Moreover, since the use of antibiotics as chiral selectors in CE has grown in the last years, a new section devoted to this aspect has been included. This review constitutes an update of previous published reviews and covers the literature published from June 2011 until June 2013.

show abstract

Section: Antibiotics As Chiral Selectors In Cementioning

confidence: 99%

Recent advances in CE analysis of antibiotics and its use as chiral selectors

et al. 2014

View full text Add to dashboard Cite

show abstract

“…α‐Methylbenzylamine, R , S ‐tryptophanol, R , S ‐norepine‐phrine, R , S ‐octopamine, R , S ‐ p ‐hydroxynorephedrine, and R , S ‐2‐amino‐1‐phenylethanol have been studied in nonaqueous CE, using boromycin (a stereogenic borate moiety containing macrodiolide antibiotic) . The best separation conditions reached resolutions between 0.4 ( R , S ‐tryptophanol) and 3.5 ( R , S ‐2‐amino‐1‐phenylethanol).…”

Section: Enantioselective Separationsmentioning

confidence: 99%

Recent advances in amino acid analysis by capillary electromigration methods, 2011–2013

et al. 2013

View full text Add to dashboard Cite

This article describes the most important research published on amino acid (AA) analysis using CE during the period from June 2011 to May 2013, and follows the format of the previous articles of Smith (Electrophoresis 1999, 20, 3078-3083), Prata et al. (Electrophoresis 2001, 22, 4129-4138), and Poinsot et al. (Electrophoresis 2003, 24, 4047-4062; Electrophoresis 2006, 27, 176-194; Electrophoresis 2008, 29, 207-223; Electrophoresis 2010, 31, 105-121; Electrophoresis 2012, 33, 14-35). We present new developments in AA analysis with CE, mainly describing the use of MS or LEDs for detection following conventional or enantiomeric separation developments. In addition, in an application part, we describe neurochemical or clinical studies, metabolomics for plant extracts and biological fluids, and finally works focused on AAs in food and agricultural applications.

show abstract

“…The macrolide antibiotic boromycin (Fig. ) was introduced for the enantioseparation of racemic primary amines . Due to the poor solubility in aqueous media, the experiments were performed in nonaqueous BGE consisting of 75 mM Tris/50 mM boric acid in methanol.…”

Section: New Chiral Selectors In Cementioning

confidence: 99%

Recent advances in electrodriven enantioseparations

Jáč

Scriba

2012

J of Separation Science

110

View full text Add to dashboard Cite

Capillary electromigration techniques have developed into significant analytical separation tools especially for enantioseparations. While CE can be considered a mature technique as documented by its wide applications, CEC is still in a developmental state despite many research efforts. The success of stereospecific CE separation methods is due to the high specificity and flexibility of the technique as well as the availability of many types of chiral selectors. Thus, numerous methods have been developed for the analysis of chiral compounds in chemical, biochemical, pharmaceutical, environmental, and forensic sciences. However, most reported applications deal with pharmaceuticals. The search for new chiral selectors also continued despite the fact that most applications were performed using cyclodextrins. Furthermore, CE has been combined with spectroscopic and molecular modeling studies in attempts to understand the interactions between chiral selectors and analytes. The present review focuses on recent examples of mechanistic aspects of capillary enantioseparations with regard to mathematical modeling of enantioseparations, investigations of the analyte-complex structures as well as new chiral selectors and applications of chiral analyses by CE and CEC. It covers the literature published between January 2011 and August 2012.

show abstract

Study on the use of boromycin as a chiral selector in capillary electrophoresis

Cited by 32 publications

References 24 publications

Recent advances in CE analysis of antibiotics and its use as chiral selectors

Recent advances in CE analysis of antibiotics and its use as chiral selectors

Recent advances in amino acid analysis by capillary electromigration methods, 2011–2013

Recent advances in electrodriven enantioseparations

Contact Info

Product

Resources

About