The effects of gas-liquid inlet geometry and mixing method on adiabatic gas-liquid two-phase flow in a microchannel of 100 μm diameter have been investigated using a T-junction inlet with the same internal diameter as the microchannel. Two-phase flow patterns, void fraction, and friction pressure drop data obtained with the T-junction inlet were found to be significantly different from those obtained previously with a reducer inlet. For the T-junction inlet, the two-phase flow patterns in the microchannel were predominantly intermittent flows with short gas and liquid plugs/slugs flowing with nearly equal velocities. The void fraction data then conformed nearly to that of a homogeneous flow model, and the two-phase friction multiplier data could be described by the Lockhart–Martinelli correlation applicable to larger channels. However, when a reducer inlet was used previously and the diameter of the inlet section was much larger than that of the microchannel, an intermittent flow of long gas slugs separated by long liquid slugs became prevalent and the void fraction decreased to values far below the homogeneous void fraction. The differences in the two-phase flow characteristics between a T-junction inlet and reducer inlet were attributed to the differences in the gas bubble/slug generation mechanisms.