“…These phenolic components in the seeds and peels of avocado tend to increase with the ripening of the fruit, the explanation for this phenomenon is probably due to the release of tannins located in the structure of the cell wall (López-Cobo et al, 2016). The higher design levels BBD corresponding to temperature, ethanol concentration and extraction time caused a drop in the content of polyphenols (Figure 3), this may be due to the that many compounds are hydrolyzed and oxidized at high temperatures, especially when extraction occurs over long periods (Bi, Yang, Sun, Chen, & Zhang, 2011;Dai, & Mumper, 2010). Temperatures > 60 °C decrease the phenolic content in extracts (Akowuah, Mariam, & Chin, 2009).…”