Carbon fibre-reinforced polymer (CFRP) composites have found wide applications in the aerospace, marine, sports and automotive industries owing to their lightweight and acceptable mechanical properties compared to the commonly used metallic materials. Machining of CFRP composites using lasers can be challenging due to inhomogeneity in the material properties and structures, which can lead to thermal damages during laser processing. In the previous studies, Nd:YAG, diode-pumped solidstate, CO 2 (continuous wave), disc and fibre lasers were used in cutting CFRP composites and the control of damages such as the size of heat-affected zones (HAZs) remains a challenge. In this paper, a short-pulsed (8 ls) transversely excited atmospheric pressure CO 2 laser was used, for the first time, to machine CFRP composites. The laser has high peak powers (up to 250 kW) and excellent absorption by both the carbon fibre and the epoxy binder. Design of experiment and statistical modelling, based on response surface methodology, was used to understand the interactions between the process parameters such as laser fluence, repetition rate and cutting speed and their effects on the cut quality characteristics including size of HAZ, machining depth and material removal rate (MRR). Based on this study, process parameter optimization was carried out to minimize the HAZ and maximize the MRR. A discussion is given on the potential applications and comparisons to other lasers in machining CFRP.