Study the prevalence of torque teno (TT) virus infection in patients with hematological malignancies

Bagheri, Kambiz; Yaghobi, Ramin; Karimi, Mohammad; Mohammadi, Behnam; Ramzi, Mani

doi:10.5897/ajmr12.598

Cited by 2 publications

(7 citation statements)

References 25 publications

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“…Within the relatively narrow confines of Jordan (the farthest samples are less than 450 km apart), no significant differences in prevalence among regions were detected. This is to be contrasted with a number of studies of much larger countries which reported geographical variation in TTV prevalence (3%-72% in India [36,37]; 2%-34% in Iran [9,23] and 6%-85% in Brazil [38][39][40]). The fact that these wide ranges were reported by different studies per country, leaves open the possibility that the observed within-country difference in prevalence might be at least partly due to variation in methodology (sampling scheme, sets of primers used, year of study, etc.)…”

Section: Discussionmentioning

confidence: 61%

“…Torque teno virus (TTV) is the most common component of the blood virobiota that does not directly cause human and animal diseases [5,6]. Since its discovery in 1997, TTV has been found to be prevalent among human populations across the globe [7][8][9][10]. Furthermore, it has also been isolated from a wide array of wild and domestic animals, including non-human primates, cats, dogs, pigs, sheep, cattle, camels, horses and chickens [11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

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The Molecular Epidemiology and Phylogeny of Torque Teno Virus (TTV) in Jordan

Sarairah

Bdour

Gharaibeh

2020

Viruses

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Torque teno virus (TTV) is the most common component of the human blood virobiota. Little is known, however, about the prevalence of TTV in humans and the most common farm domesticates in Jordan, or the history and modality of TTV transmission across species lines. We therefore tested sera from 396 Jordanians and 171 farm animals for the presence of TTV DNA using nested 5′-UTR-PCR. We then performed phylogenetic, ordination and evolutionary diversity analyses on detected DNA sequences. We detected a very high prevalence of TTV in Jordanians (~96%); much higher than in farm animal domesticates (~29% pooled over species). TTV prevalence in the human participants is not associated with geography, demography or physical attributes. Phylogenetic, ordination and evolutionary diversity analyses indicated that TTV is transmitted readily between humans across the geography of the country and between various species of animal domesticates. However, the majority of animal TTV isolates seem to derive from a single human-to-animal transmission event in the past, and current human-animal transmission in either direction is relatively rare. In conclusion, animal TTV in Jordan is historically derived from human variants; however, ongoing human-animal TTV exchange is minimal and zoonotic infection seems to be of limited importance.

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Section: Discussionmentioning

confidence: 61%

Section: Introductionmentioning

confidence: 99%

The Molecular Epidemiology and Phylogeny of Torque Teno Virus (TTV) in Jordan

Sarairah

Bdour

Gharaibeh

2020

Viruses

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“…The primer pair sequences used in simple and semi-nested PCR steps were NG059, NG061 and NG063 (CinnaGen-Tehran-Iran) that amplified the 286 bp and 271 bp fragments of the N22 open reading frame 1 (ORF1) of TT Virus genome, respected to length of amplified products. The details of simple and semi-nested PCR mix and thermocycling conditions were as previously described ( 13 ).…”

Section: Methodsmentioning

confidence: 99%

“…However, a higher prevalence of TT Virus infection has been reported in high-risk patients including: 68% of patients with hemophilia, 46% of patients on hemodialysis, 40% of intravenous drug abusers, and 17.8% of patients with hematological malignancies ( 12 , 13 ). Among these high-risk hematopoietic disorders, associations may exist between TT Virus infection and pathogenesis of different acute and chronic hematologic malignancies ( 2 , 13 , 14 ). This hypothesis is based on diagnosis of higher elevated titer of TT Virus genomic DNA in PBMCs of patients with cancers compared with controls ( 15 , 16 ).…”

Section: Introductionmentioning

confidence: 99%

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Study of the Associations Between TT Virus Single and Mixed Infections With Leukemia

Shaheli

Yaghobi

Rezaeian

et al. 2015

Jundishapur J Microbiol

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Background:The pathogenic association of Transfusion Transmitted Virus or Torque teno Virus (TT Virus) single and mixed infections with leukemia was under evaluation in these years but confront with controversies. This hypothesis is based on the higher prevalence of TT Virus infection in patients with leukemia compared with controls.Objectives:The aim of this study was to determine the frequency of TT Virus, Cytomegalovirus (CMV), Hepatitis B Virus (HBV), and Hepatitis C Virus (HCV) infections in patients with leukemia and healthy controls.Patients and Methods:In this cross sectional study, 95 patients with leukemia and 100 healthy controls who were admitted to the Namazi Hospital affiliated to the Shiraz University of Medical Sciences, Shiraz, Iran, were enrolled between years 2012 and 2013. Blood samples treated with EDTA were collected from each patient with leukemia and controls. The existence of TT Virus infection was analyzed using the semi-nested PCR method. The immunological prevalence of HBV and HCV infections were evaluated using HBs-Ag and HCV-Ab ELISA based protocols, respectively. Active CMV infection was also evaluated using an immunofluorescence method. Also risk factors of leukemia and viral infections were statistically analyzed in patients with leukemia.Results:The TT Virus infection was significantly found in 40 of 95 (42.1%) and 12 of 100 (12%) patients with leukemia and controls, respectively. The HBs-Ag and HCV-Ab were detected in 27 of 95 (28.4%) and 18 of 69 (26.1%) patients with leukemia but were not found in the controls. Active CMV infection was also found in 11 of 69 (16%) patients and none of the controls. Significant co-infection of TT Virus was found with HBV (15 of 40; 37.5%), HCV (14 of 40; 35%) and CMV (7 of 40; 17.5%) in patients with leukemia.Conclusions:Confirmation of the significantly higher frequency of TT Virus, HBV, HCV and CMV single infection and their co-infection in patients with leukemia compared with healthy controls, emphasizes the determinative role of TT Virus pathogenesis in clinical outcomes observed in patients with leukemia, which requires extensive evaluation by further studies.

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Study the prevalence of torque teno (TT) virus infection in patients with hematological malignancies

Cited by 2 publications

References 25 publications

The Molecular Epidemiology and Phylogeny of Torque Teno Virus (TTV) in Jordan

The Molecular Epidemiology and Phylogeny of Torque Teno Virus (TTV) in Jordan

Study of the Associations Between TT Virus Single and Mixed Infections With Leukemia

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