Studying Pellet Formation of a Filamentous Fungus Rhizopus oryzae to Enhance Organic Acid Production

Liao, Wei; Liu, Yan; Chen, Shulin

doi:10.1007/978-1-60327-181-3_56

Cited by 4 publications

(1 citation statement)

References 22 publications

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“…Conversely, the simplicity of synthetic media limited the growth of fungi in this study. Similar findings were reported by Liao et al (2007) when comparing PDB with glucose as carbon sources to grow Rhizopus oryzae , and both were supplied with minerals. They concluded that the vitamins in PDB were the main substances influencing the fungal morphology.…”

Section: Resultssupporting

confidence: 88%

Potential of utilizing almond hull extract for filamentous fungi production by submerged cultivation

Cao,

Barzee,

El Mashad

et al. 2024

Food Bioengineering

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Almond hulls can be used as an inexpensive source of nutrients for producing fungi that can be used as nontraditional foods such as alternative protein, probiotics, and food ingredients. Nutrients were extracted from almond hulls using hot water and their utility in cultivating filamentous fungus Aspergillus awamori (A. awamori) in submerged cultivation was investigated using batch fermentation in flasks with passive aeration. The almond hulls extract supplied all the nutrients required for A. awamori growth. The uptake preference of various sugars was investigated and the growth kinetic parameters of A. awamori were determined. Utilization of sugars by A. awamori grown in almond hull extract proceeded sequentially with preference for glucose followed by sucrose, fructose, and then xylose. Compared to potato dextrose broth medium, the fungal biomass produced using almond hull extract as growth medium had higher protein (19.59%) and lower fat (1.50%) contents. The modified Gompertz model described the kinetics of A. awamori well with a lag phase of 0.18 days and a specific growth rate of 1.77 d−1.

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Section: Resultssupporting

confidence: 88%

Potential of utilizing almond hull extract for filamentous fungi production by submerged cultivation

Cao,

Barzee,

El Mashad

et al. 2024

Food Bioengineering

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Optimization of biotransformation processes of Camarosporium laburnicola to improve production yields of potent telomerase activators

Küçüksolak,

Çoban,

Bedir

2024

Microb Cell Fact

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Background Telomerase activators are promising agents for the healthy aging process and the treatment/prevention of short telomere-related and age-related diseases. The discovery of new telomerase activators and later optimizing their activities through chemical and biological transformations are crucial for the pharmaceutical sector. In our previous studies, several potent telomerase activators were discovered via fungal biotransformation, which in turn necessitated optimization of their production. It is practical to improve the production processes by implementing the design of experiment (DoE) strategy, leading to increased yield and productivity. In this study, we focused on optimizing biotransformation conditions utilizing Camarosporium laburnicola, a recently discovered filamentous fungus, to afford the target telomerase activators (E-CG-01, E-AG-01, and E-AG-02). Results DoE approaches were used to optimize the microbial biotransformation processes of C. laburnicola. Nine parameters were screened by Plackett-Burman Design, and three significant parameters (biotransformation time, temperature, shaking speed) were optimized using Central Composite Design. After conducting validation experiments, we were able to further enhance the production yield of target metabolites through scale-up studies in shake flasks (55.3-fold for E-AG-01, 13-fold for E-AG-02, and 1.96-fold for E-CG-01). Conclusion Following a process optimization study using C. laburnicola, a significant increase was achieved in the production yields. Thus, the present study demonstrates a promising methodology to increase the production yield of potent telomerase activators. Furthermore, C. laburnicola is identified as a potential biocatalyst for further industrial utilization.

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Fumaric acid: fermentative production, applications and future perspectives

Mohmad

Agnihotri

Kumar

2022

Physical Sciences Reviews

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The rising prices of petroleum-based chemicals and the growing apprehension about food safety and dairy supplements have reignited interest in fermentation process to produce fumaric acid. This article reviews the main issues associated with industrial production of fumaric acid. Different approaches such as strain modulation, morphological control, selection of substrate and fermentative separation have been addressed and discussed followed by their potential towards production of fumaric acid at industrial scale is highlighted. The employment of biodegradable wastes as substrates for the microorganisms involved in fumaric acid synthesis has opened an economic and green route for production of the later on a commercial scale. Additionally, the commercial potential and technological approaches to the augmented fumaric acid derivatives have been discussed. Conclusion of the current review reveals future possibilities for microbial fumaric acid synthesis.

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Studying Pellet Formation of a Filamentous Fungus Rhizopus oryzae to Enhance Organic Acid Production

Cited by 4 publications

References 22 publications

Potential of utilizing almond hull extract for filamentous fungi production by submerged cultivation

Potential of utilizing almond hull extract for filamentous fungi production by submerged cultivation

Optimization of biotransformation processes of Camarosporium laburnicola to improve production yields of potent telomerase activators

Fumaric acid: fermentative production, applications and future perspectives

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