Styrene based copolymers for consistent reactivity ratio evaluation

Zaremba, Daniel; Menzel, Henning; Kowalsky, Wolfgang; Johannes, Hans‐Hermann

doi:10.1016/j.matchemphys.2018.01.077

Cited by 7 publications

(4 citation statements)

References 15 publications

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“…MAA:BA copolymers also exhibit phase separation (the samples a hazy and show two glass transitions, as illustrated in the DSC data shown in Figure S5, Supporting Information) due to reactivity ratio differences. [32][33][34][35] This results in localized areas with high concentrations of MAA units that may degrade relatively fast, and thus is responsible for the small influence of comonomer concentration on the erosion profiles. Consequently, more BA units remain toward the end of the degradation time span.…”

Section: Copolymer Erosion Profilesmentioning

confidence: 99%

Surface Eroding Methacrylic Anhydride Copolymers and Model Drug Release

Santefort,

Appolon,

Cowart

et al. 2023

Macro Chemistry & Physics

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Methacrylic anhydride (MAA)‐based copolymers are synthesized to probe how comonomer composition and type affect the erosion profiles. Anhydrides readily undergo hydrolysis, which when combined with high crosslink density and hydrophobicity tend to exhibit an ideal surface erosion mechanism for drug delivery, tissue adhesives, and biocement applications. The cylindrical (10 mm diameter × 5 mm height) polyanhydrides are degraded under pseudo‐physiological conditions and surface erosion is qualitatively observed via photographs. The non‐anhydride comonomer can be utilized to tune erosion profiles while retaining degradability and product solubility. The comonomer can accelerate or slow the degradation process to a greater extent at low MAA concentrations. Drug release is conducted using purpurin to model hydrophobic drugs. Purpurin concentration is quantified using UV–visible spectral analysis. Purpurin extends the degradation profile due to a combination of local pH changes, hydrophobicity, and molecular diffusion. Linear purpurin release is observed as a function of polymer erosion (0.9897 R2) thus confirming a surface erosion‐mediated drug release mechanism.

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Section: Copolymer Erosion Profilesmentioning

confidence: 99%

Surface Eroding Methacrylic Anhydride Copolymers and Model Drug Release

Santefort,

Appolon,

Cowart

et al. 2023

Macro Chemistry & Physics

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“…In general, styrene (S) is chosen as the reference monomer with Q M(S) = 1 and e M(S) = −0.8, 2 and the Q-e value is obtained by applying the experimental reactivity ratio between the target monomer and styrene to eqn (1) and (2). There are several ways to determine the Q-e values, and the accuracy of the reactivity ratio predicted by the Q-e scheme not only depends on the reactivity ratios 3 used to calculate the Q-e values, but also on the calculation method employed. 4 Previously, Young and Greenley reported the Q-e values for various monomers in the Polymer Handbook.…”

Section: Introductionmentioning

confidence: 99%

Determining theQ–evalues of polymer radicals and monomers separately through the derivation of an intrinsicQ–escheme for radical copolymerization

et al. 2022

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“…Monomer reactivity ratios are very important parameters for the demonstration of copolymer structure (copolymer composition, and monomer sequence distribution) which help for the prediction of copolymer properties and the correlation between structure and properties. [23][24][25][26][27][28][29]. Hundreds of years ago, many of methods have been developed to determine and predict the (r) parameters.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and evaluation of new cationic polymeric surfactant based on N-phthalimidomethyl methacrylate

et al. 2021

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In our previous work N-phthalimidomethyl methacrylate (NPMMA) monomer was prepared through the reaction of Nhydroxymethyl phthalimide with methacrylic acid in the presence of N, N-dicyclohexylcarbodiimide (DCCI) as a condensing agent. Then a new series of copolymers containing imidazole have been synthesized through the reaction of NPMMA monomer with 1-vinylimidazole (VIM) in the presence of benzoyl peroxide as initiator. The copolymer composition was determined by 1 H NMR spectroscopy and the values of monomer reactivity ratio (r1= 0.756, r2= 1.033, and r1r2= 0.781) were calculated through Fineman Ross and Kelen-Tüdös methods. Conversion of copolymers to surfactants was achieved through quaternization of the imidazole nitrogen with dimethyl sulphate. The chemical structure of the produced monomer, copolymers, co-polymeric surfactants was confirmed by spectroscopic tools. The surface properties included surface tension, foaming power, emulsion stability, critical micelle concentration (CMC) have been measured in aqueous medium by traditional procedures. Also the different air/ water interface parameters including effectiveness (πcmc), efficiency (Pc20), maximum surface excess (Γmax) and minimum surface area (Amin) were also recorded. Moreover, the biodegradability for these cationic surfactants has been investigated and their D % was ranged from 67 to 100 %.

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Styrene based copolymers for consistent reactivity ratio evaluation

Cited by 7 publications

References 15 publications

Surface Eroding Methacrylic Anhydride Copolymers and Model Drug Release

Surface Eroding Methacrylic Anhydride Copolymers and Model Drug Release

Determining theQ–evalues of polymer radicals and monomers separately through the derivation of an intrinsicQ–escheme for radical copolymerization

Synthesis and evaluation of new cationic polymeric surfactant based on N-phthalimidomethyl methacrylate

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