Styrene induces an inflammatory response in human lung epithelial cells via oxidative stress and NF-κB activation

Röder-Stolinski, Carmen; Fischäder, Gundula; Oostingh, Gertie Janneke; Feltens, Ralph; Kohse, Franziska; Bergen, Martin von; Mörbt, Nora; Eder, Klaus; Duschl, Albert; Lehmann, Irina

doi:10.1016/j.taap.2008.04.010

Cited by 47 publications

(34 citation statements)

References 37 publications

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“…Although biological functions of the 23 genes were largely unknown, many of the 23 genes have been reported to affect carcinogenesis and nervous system such as cognitive function and Parkinson's disease, areas that are known to be affected by chronic VOC exposure 2,3,9,11,25) .…”

Section: Discussionmentioning

confidence: 99%

“…The urinary levels of 8-OHdG were measured using ELISA kit (JaICA, Fukuroi, Japan). Briefly, 50 μ l of 8-OHdG monoclonal antibody and 50 μ l of the sample were added to a microtiter plate which had been precoated with 8-OHdG, and the Industrial Health 2011, 49, [8][9][10][11][12][13][14] plate was incubated at 37°C for 1 h. After washing with 250 μ l of washing solution, 100 μ l of enzymelabeled secondary antibody was added to the plate and incubated at 37°C for 1 h. After re-washing the plate, substrate solution and phosphoric acid solution were added in turn, and absorbances from the wells were measured at 450 nm using a microtiter plate reader.…”

Section: Measurement Of Urinary Biomarkersmentioning

confidence: 99%

“…Previous studies reported that exposure to VOCs induced oxidative stress in animal or cell-line studies [9][10][11] . Oxidative stress has been involved in the etiology and progression of numerous pathological condition including cancer, aging, and neurodegenerative diseases 5,12,13) .…”

Section: Introductionmentioning

confidence: 99%

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Changes in Oxidative Stress Biomarker and Gene Expression Levels in Workers Exposed to Volatile Organic Compounds

et al. 2011

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Section: Discussionmentioning

confidence: 99%

Section: Measurement Of Urinary Biomarkersmentioning

confidence: 99%

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Changes in Oxidative Stress Biomarker and Gene Expression Levels in Workers Exposed to Volatile Organic Compounds

et al. 2011

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“…Exposure to VOCs may cause upper and lower respiratory symptoms and contribute to the worsening of asthma. The mechanisms of VOC toxicity, however, have yet to be established, even though some experimental evidence supports oxidative stress having a role [1][2][3].…”

mentioning

confidence: 99%

Exposure to volatile organic compounds and loss of pulmonary function in the elderly

Yoon

Hong²,

Cho³

et al. 2010

Eur Respir J

119

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Volatile organic compounds (VOCs) are reported to cause adverse effects on pulmonary function in occupationally exposed workers. However, evidence is lacking on the effect in the general population. We hypothesised that VOCs impair pulmonary function through enhancing oxidative stress, especially in the elderly population.A longitudinal panel study of 154 elderly people was performed in South Korea. Repeated spirometric tests were performed up to eight times on different days for each subject. We also measured urinary concentrations of metabolites of the VOC and markers of oxidative stress (malondialdehyde and 8-oxo-29-deoxyguanosine) on the same day of spirometric tests. A mixed linear regression model was used to evaluate the association among the VOC metabolites, oxidative stress markers and spirometric tests.We found that the urinary levels of hippuric acid and methylhippuric acid, which are metabolites of toluene and xylene, respectively, were significantly associated with reduction of forced expiratory volume in 1 s (FEV1), FEV1/forced vital capacity (FVC), and forced expiratory flow at 25-75% of FVC. We also found significant associations between the metabolites of VOCs and the markers of oxidative stress. In addition, the oxidative stress markers were associated with pulmonary function parameters.This study suggests that exposure to toluene and xylene exert a harmful effect on pulmonary function by exacerbating oxidative stress in elderly people.

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“…Beside this, activation of NFκB leads to enhanced expression of genes which are involved in immune responses, e.g. the chemotactic cytokine monocyte chemoattractant Protein-1 (MCP-1) (Roder-Stolinski et al 2008) or the infl ammatory cytokines TNF-α, IL-1, IL-6, IL-12 and IL-23 (Atreya et al 2008). It has been described that vitamin C decreases the intra-cytoplamatic production of pro-infl ammatory cytokines IL-2, IL-6 and TNF-α in lipopolysaccharid (LPS) or phorbol 12-myristate 13-acetate (PMA) stimulated lymphocytes dose-dependently (Hartel et al 2004).…”

Section: Nutrition and Immune Systemmentioning

confidence: 99%

Early nutrition and allergy

et al. 2008

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The perinatal phase is crucial for the development of the infant. The fi rst priming of the immune system occurs before birth, and this process is infl uenced by the intrauterine environment. One factor of this priming seems to be the fetal nutrition, which mainly depends on maternal diet. After birth, breastfeeding offers optimal alimentation. Allergy prevalence has increased during the last decades. As a method of primary allergy prevention, exclusive breastfeeding for a period of 4 to 6 months is recommended. However, published data on the subject is confl icting. Therefore, this review article will focus on maternal nutrition during breastfeeding with regard to allergy development. Cytokine levels in breast milk seem to depend on maternal state of atopy as well as on her nutrition. Breast milk components can, on the other hand, infl uence immune response of the infant. Differences between recent studies concerning composition of breast milk regarding allergen content, immune mediators and nutrients are discussed and the role of early nutrition on long-term development in the offspring is shown. To summarize -albeit some confl icting results are published -a healthy and balanced maternal nutrition, rich in fresh fruit and vegetables, milk products, nuts or oily fi sh, and breastfeeding of the infant seems to be the best way of childhood atopy prevention.

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Styrene induces an inflammatory response in human lung epithelial cells via oxidative stress and NF-κB activation

Cited by 47 publications

References 37 publications

Changes in Oxidative Stress Biomarker and Gene Expression Levels in Workers Exposed to Volatile Organic Compounds

Changes in Oxidative Stress Biomarker and Gene Expression Levels in Workers Exposed to Volatile Organic Compounds

Exposure to volatile organic compounds and loss of pulmonary function in the elderly

Early nutrition and allergy

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