SU‐E‐T‐96: Energy Dependence of the New GafChromic‐ EBT3 Film's Dose Response‐Curve

Chiu‐Tsao, Sou‐Tung; Massillon‐JL, G.; Domingo-Muñoz, I; Chan, M

doi:10.1118/1.4735153

Cited by 22 publications

(23 citation statements)

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“…Other advantages of choosing smaller resolution might include smaller image file size and quicker scanning time due to lesser working memory requirement. However, Chiu-Tsao et al [25] argued that a sharper resolution of 300 dpi would be crucial for brachytherapy and other small field applications (stereotactic radiosurgery, stereotactic body radiation therapy) as an accurate dose distribution measurement are highly demanded.…”

Section: Discussionmentioning

confidence: 99%

Effect of scanning parameters on dose-response of radiochromic films irradiated with photon and electron beams

Tagiling

Rashid

Azhan

et al. 2018

Heliyon

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Proper dosimetry settings are crucial in radiotherapy to ensure accurate radiation dose delivery. This work evaluated scanning parameters as affecting factors in reading the dose-response of EBT2 and EBT3 radiochromic films (RCFs) irradiated with clinical photon and electron beams. The RCFs were digitised using Epson® Expression® 10000XL flatbed scanner and image analyses of net optical density (netOD) were conducted using five scanning parameters i.e. film type, resolution, image bit depth, colour to grayscale transformation and image inversion. The results showed that increasing spatial resolution and deepening colour depth did not improve film sensitivity, while grayscale scanning caused sensitivity reduction below than that detected in the Red-channel. It is also evident that invert and colour negative film type selection negated netOD values, hence unsuitable for scanning RCFs. In conclusion, choosing appropriate scanning parameters are important to maintain preciseness and reproducibility in films dosimetry.

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Section: Discussionmentioning

confidence: 99%

Effect of scanning parameters on dose-response of radiochromic films irradiated with photon and electron beams

Tagiling

Rashid

Azhan

et al. 2018

Heliyon

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“…Far too many publications fail to provide sufficient detail to enable replication of radiation delivery, and even fewer provide details regarding the frequency and type of calibration performed [57]. At our institution, monthly quality assurance (QA) is performed by a member of the UW Calibration Lab using a custom-built compact 4 × 4 cm phantom and Gafchromic EBT3 film which has known spatial precision and relatively flat energy response [58]. At a minimum, we suggest that monthly QA be performed to ensure the dose The transition from cesium irradiators, with their easily calculated dose rate, has highlighted the importance of dosimetric validation for pre-clinical irradiation.…”

Section: Radiation Deliverymentioning

confidence: 99%

Patient Derived Models to Study Head and Neck Cancer Radiation Response

Cosper

Abel

Lee

et al. 2020

Cancers

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Patient-derived model systems are important tools for studying novel anti-cancer therapies. Patient-derived xenografts (PDXs) have gained favor over the last 10 years as newer mouse strains have improved the success rate of establishing PDXs from patient biopsies. PDXs can be engrafted from head and neck cancer (HNC) samples across a wide range of cancer stages, retain the genetic features of their human source, and can be treated with both chemotherapy and radiation, allowing for clinically relevant studies. Not only do PDXs allow for the study of patient tissues in an in vivo model, they can also provide a renewable source of cancer cells for organoid cultures. Herein, we review the uses of HNC patient-derived models for radiation research, including approaches to establishing both orthotopic and heterotopic PDXs, approaches and potential pitfalls to delivering chemotherapy and radiation to these animal models, biological advantages and limitations, and alternatives to animal studies that still use patient-derived tissues.

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“…Far too many publications fail to provide sufficient detail to enable replication of radiation delivery and even fewer provide details regarding the frequency and type of calibration performed [50]. At our institution, monthly quality assurance is performed by a member of the UW Calibration Lab using a custom-built compact 4x4cm phantom and Gafchromic EBT3 film which has known spatial precision and relatively flat energy response [51]. At a minimum, we suggest that monthly QA be performed to ensure the dose rate is correct and, for small animal image guided systems, to confirm alignment of the beam with the isocenter.…”

Section: Radiation Deliverymentioning

confidence: 99%

Patient Derived Models to Study Head and Neck Cancer Radiation Response

Cosper¹,

Abel²,

Lee³

et al. 2020

Preprint

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Patient derived model systems are important tools for studying novel anti-cancer therapies. Patient derived xenografts (PDXs) have gained favor over the last 10 years as newer mouse strains have improved the success rate of establishing PDXs from patient biopsies. PDXs can be engrafted from head and neck cancer (HNC) samples across a wide range of cancer stages, retain the genetic features of their human source, and can be treated with both chemotherapy and radiation, allowing for clinically relevant studies. Not only do PDXs allow for study of patient tissues in an in vivo model, they can also provide a renewable source of cancer cells for organoid cultures. Herein, we review the uses of HNC patient derived models for radiation research including approaches to establishing both orthotopic and heterotopic PDXs, approaches and potential pitfalls to delivering chemotherapy and radiation to these animal models, biological advantages and limitations, and alternatives to animal studies that still use patient-derived tissues.

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SU‐E‐T‐96: Energy Dependence of the New GafChromic‐ EBT3 Film's Dose Response‐Curve

Cited by 22 publications

References 0 publications

Effect of scanning parameters on dose-response of radiochromic films irradiated with photon and electron beams

Effect of scanning parameters on dose-response of radiochromic films irradiated with photon and electron beams

Patient Derived Models to Study Head and Neck Cancer Radiation Response

Patient Derived Models to Study Head and Neck Cancer Radiation Response

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