Su1149 Lack of Seasonal Variation in the Incidence of Eosinophilic Esophagitis

Frederickson, Nicholas W; Lee, Ye-Jin; Redd, Matthew K.; Go, Jorge; Valestin, Jessica; Schey, Ron

doi:10.1016/s0016-5085(12)61646-1

Cited by 3 publications

(3 citation statements)

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“…Hurrel et al ( 22 ) found a high prevalence of esophageal eosinophilia in adult patients living within the colder geographical climates of the US compared to those living in warmer areas. Other similar studies have also not supported seasonal variations ( 23 ).…”

Section: Epidemiologymentioning

confidence: 79%

“…A molecule with similar function to MBP, MMP-9 can be generated by structural and inflammatory cells and has the ability to secrete and activate latent matrix-bound growth factors ( 42 ). MMP-9 can thus degrade proteoglycans thereby enhancing airway fibrosis and smooth muscle proliferation ( 23 ). Although current research implicate MBP and MMP-9 in cell proliferation and tissue fibrosis, it must be highlighted that these molecules may have an organ-specific function, in which case their effect on bronchial remodeling may not be able to be generalized to esophageal remodeling.…”

Section: The Pathophysiology Of Eoementioning

confidence: 99%

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The Pathophysiology of Eosinophilic Esophagitis

et al. 2014

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Eosinophilic esophagitis (EoE) is an emerging disease characterized by esophageal eosinophilia (>15eos/hpf), lack of responsiveness to acid-suppressive medication and is managed by allergen elimination and anti-allergy therapy. Although the pathophysiology of EoE is currently unsubstantiated, evidence implicates food and aeroallergen hypersensitivity in genetically predisposed individuals as contributory factors. Genome-wide expression analyses have isolated a remarkably conserved gene-expression profile irrespective of age and gender, suggesting a genetic contribution. EoE has characteristics of mainly TH2 type immune responses but also some TH1 cytokines, which appear to strongly contribute to tissue fibrosis, with esophageal epithelial cells providing a hospitable environment for this inflammatory process. Eosinophil-degranulation products appear to play a central role in tissue remodeling in EoE. This remodeling and dysregulation predisposes to fibrosis. Mast-cell-derived molecules such as histamine may have an effect on enteric nerves and may also act in concert with transforming growth factor-β to interfere with esophageal musculature. Additionally, the esophageal epithelium may facilitate the inflammatory process under pathogenic contexts such as in EoE. This article aims to discuss the contributory factors in the pathophysiology of EoE.

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Section: Epidemiologymentioning

confidence: 79%

Section: The Pathophysiology Of Eoementioning

confidence: 99%

The Pathophysiology of Eosinophilic Esophagitis

et al. 2014

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“…7,9 Few investigators reported an increase incidence of EoE during the allergy seasons (low during winter, high during spring and fall), 3-5 but those findings were not confirmed by others. [10][11][12] In the present study, we showed that the diagnosis of EoE in children from the rural communities was evenly spread throughout the year without any seasonal preference. We explain these results by the various confounding factors that may modify the phenotypic expression of EoE such as: the geographic location of our patient population (rural area), low air pollution in the area (http://airnow.…”

Section: To the Editormentioning

confidence: 81%

Seasonal Distribution and Eosinophilic Esophagitis

Elitsur

Aswani

Lund

et al. 2013

Journal of Clinical Gastroenterology

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Eosinophilic Esophagitis: Current Treatment

Redd

Schey

2012

Dig Dis Sci

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Eosinophilic esophagitis (EoE) is a relatively new entity with a significant amount of increased recognition over the last decade. The mainstay treatments of EoE are designed to eliminate the causative allergens or to reduce their effects on the esophageal mucosa. Common treatments include dietary modification, proton pump inhibitors, systemic and topical corticosteroids, and endoscopic treatments. As the pathogenesis of EoE is explored, new and novel treatments are being studied that target specific pathways and chemokines identified in as precipitating agents of EoE. This is a rapidly evolving field with significant ongoing research and clinical studies. Our review will therefore focus on current and novel treatment approaches to the disease.

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Su1149 Lack of Seasonal Variation in the Incidence of Eosinophilic Esophagitis

Cited by 3 publications

References 0 publications

The Pathophysiology of Eosinophilic Esophagitis

The Pathophysiology of Eosinophilic Esophagitis

Seasonal Distribution and Eosinophilic Esophagitis

Eosinophilic Esophagitis: Current Treatment

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