Sub-acute cutaneous lupus erythematosus following nitrofurantoin: causative or coincidental?

Murie, Jill; Agarwal, Monica

doi:10.1177/0036933014558000

Cited by 6 publications

(1 citation statement)

References 7 publications

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“…Nitrofurantoin is an antibiotic commonly used to treat urinary tract infections and was identified as the major compound in many worldwide drug residue violations ( 32 ). Nitrofurantoin has been reported to induce immune-mediated lung and liver disease ( 33 ), sub-acute cutaneous lupus erythematosus ( 34 ), and antineutrophilcytoplasmic antibodies (ANCA)-associated vasculitis ( 35 ) in some rare cases. Nitrofurantoin can induce both humoral and cellular immune responses, increasing the T helper/T-suppressor lymphocytes ratio, and stimulating the production of autoantibodies ( 36 , 37 ).…”

Section: Discussionmentioning

confidence: 99%

Identification of Novel Environmental Substances Relevant to Pediatric Graves’ Disease

Qin

Liu

et al. 2021

Front. Endocrinol.

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Graves’ disease (GD) is the most common cause of hyperthyroidism, yet a relatively rare disease in the pediatric population. GD is a complex disorder influenced by both genetic and environmental factors. In this study, we aimed to find new environmental factors influencing the pathogenesis of GD. We investigated serum substances in 30 newly diagnosed GD children and 30 age- and gender-matched healthy controls. We measured total iodine by inductively coupled plasma-mass spectrometry (ICP-MS), analyzed perfluorinated compounds via ultra-high-performance liquid chromatography coupled with multiple reaction monitoring mass spectrometry (UHPLC-MRM-MS), and explored other environmental substances using ultra-high-performance liquid chromatography–quadrupole time-of-flight mass spectrometry (UHPLC–QTOF/MS) analysis. Twenty-nine single-nucleotide polymorphisms (SNPs) in eight genes related to GD were analyzed by SNaPshot. The serum total iodine was significantly higher in GD group, but its association with GD onset was weak, only with Exp(B) value near 1. The perfluorinated compound levels were not different between the two groups. More importantly, we found 16 environmental substances significantly different between GD and control groups, among which ponasterone A is a risk factor (p = 0.007 and Exp(B) = 14.14), while confertifoline is a protective factor against GD onset (p = 0.002 and Exp(B) = 0.001). We also identified 10 substances correlated significantly with thyroid indices in GD patients, among which seven associated with levels of the thyroid autoantibody TPOAb. No known SNPs were found predisposing GD. In this study, we explored a broad variety of environmental substances and identified novel factors that are potentially involved in the pediatric GD pathogenesis.

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Section: Discussionmentioning

confidence: 99%

Identification of Novel Environmental Substances Relevant to Pediatric Graves’ Disease

Qin

Liu

et al. 2021

Front. Endocrinol.

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Lupus Erythematosus and Antiphospholipid Syndrome

Dutz,

Khosravi‐Hafshejani

2024

Rook's Textbook of Dermatology

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Lupus erythematosus is an autoimmune disease that commonly affects the skin, and may present with cutaneous only disease. This chapter reviews the forms of cutaneous lupus‐specific skin disease (discoid lupus, subacute cutaneous lupus, lupus tumidus and acute cutaneous lupus), their clinical features, pathogenesis and treatment. A review of systemic lupus erythematosus is also provided with a discussion of diagnosis, clinical features, cutaneous aspects and treatment, germane for the dermatologist. Clinical features of neonatal lupus erythematosus and the antiphospholipid antibody syndrome, more commonly seen in systemic lupus erythematosus kindreds, are also discussed.

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Sonochemically Synthesised Nano‐Stone Structured Vanadium Tungstate for Electrochemical Monitoring of Antibiotic Drug Nitrofurantoin in Real Samples

Mohanty,

Manikanta,

Mounesh

et al. 2024

ChemistrySelect

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The development of simple, accurate, responsive, and selective antimicrobial drug analysis platforms is extremely important for biomedical research. Developing a novel electrode material that possesses low detection limit, high sensitivity, and stability continues to be a difficult undertaking. Here, vanadium tungstate nanostones (VWNs) were synthesized by utilizing facile sonochemical method with the aid of urea and ethylene glycol for application in electrochemical sensing of antibiotic drug nitrofurantoin (NFT). Using a distinct analytical methods, the structural and morphological characteristics of the as‐prepared transducer material were described. Further, electrochemical behaviour of modified electrode were analysed using cyclic voltammetry and liner sweep voltammetry. Under the optimal conditions VWNs/GCE electrode exhibited superior electrocatalytic activity towards NFT with linear range (20–160 μM), limit of detection (0.019 μM) with better sensitivity (0.69 μM−1 cm−2). The modified electrode demonstrated remarkable repeatability, reproducibility, and excellent stability, indicating its potential as an electrocatalyst. Ultimately, the suggested electrode was used to measure FLT in real samples like tap water and NFT capsule.

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Sub-acute cutaneous lupus erythematosus following nitrofurantoin: causative or coincidental?

Cited by 6 publications

References 7 publications

Identification of Novel Environmental Substances Relevant to Pediatric Graves’ Disease

Identification of Novel Environmental Substances Relevant to Pediatric Graves’ Disease

Lupus Erythematosus and Antiphospholipid Syndrome

Sonochemically Synthesised Nano‐Stone Structured Vanadium Tungstate for Electrochemical Monitoring of Antibiotic Drug Nitrofurantoin in Real Samples

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