Sub-attomolar detection of cholera toxin using a label-free capacitive immunosensor

Loyprasert, Suchera; Hedström, Martin; Thavarungkul, Panote; Kanatharana, P.; Mattìasson, Bo

doi:10.1016/j.bios.2010.01.020

Cited by 81 publications

(65 citation statements)

References 31 publications

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“…Examples include the use of gold colloids, directly immobilised to a polymer surface, in an immuno-capacitance sensor 257 and an electric tunnelling assay, 258 both for the detection of cholera toxin. The excellent sensitivity obtained in these assays and the ability to measure in diluted samples suggests these sensors could be adapted for MIP-based sensing.…”

Section: Nanotechnologymentioning

confidence: 99%

The rational development of molecularly imprinted polymer-based sensors for protein detection

et al. 2011

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The detection of specific proteins, as biomarkers of disease, health status, environmental monitoring, food quality, control of fermenters and civil defence purposes means that biosensors for these targets will become increasing more important. Among the technologies used for building specific recognition properties, molecularly imprinted polymers, molecularly imprinted polymers (MIPs) are attracting much attention. In this critical review we describe many of methods used for imprinting recognition for protein targets in polymers and their incorporation with a number of transducer platforms with the aim of identifying the most promising approaches for the preparation of MIP-based protein sensors.2

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Section: Nanotechnologymentioning

confidence: 99%

The rational development of molecularly imprinted polymer-based sensors for protein detection

et al. 2011

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“…In a fluorescent-based competition analyses, the binding affinity of the protein (Lectin Con A) against lyconanoparticles (AuNPs conjugated with underivatized mono-, oligo-and polysaccharides) was determined [50]. A wide range of additional protein biomarkers have been detected besides cancer biomarkers, including cholera toxin [55], inter-leukin [56] vascular endothelial growth factors [57], Annexin II and MUC5AC antigens [58], antigens of Schistosoma japonicum [59], Salmonella typhi [60,61], Escherichia coli O157:H7 [62] and osteoprotegerin [63]. AuNP-based electrochemical sandwich immunosensor was designed for the detection of fenolase (ENO1) antigen, a potential diagnostic marker for lung cancer, with a detection limit of 11.9 fg [64].…”

Section: Detection Of Proteinsmentioning

confidence: 99%

Gold Nanoparticles in Biosensing Analyses

Gopinath

Citartan

Lakshmipriya

et al. 2014

Nanoparticles' Promises and Risks

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Monitoring biomolecular interactions has become a constituent element of various medical and clinical applications. The importance of measuring the biomolecular interaction is evident as a potpourri of sensing strategies is currently and continuously devised. One of the strategies that can immensely enhance the sensitivity of the interaction is the one mediated by nanoparticles. Among the various nanoparticles, gold nanoparticle (AuNP) is opted for due to its capacity to improve the sensitivity and selectivity of biomolecular interactions. In addition to this, AuNP is easy to be manufactured, chemically inert, have uniform dispersibility and are able to react with chemically modified biomolecules. In this overview, the roles adopted by AuNP in various biosensing applications are discussed.

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“…Many analyses using capacitive biosensors based on e.g. antibody recognition elements are orders of magnitude more sensitive (Loyprasert et al, 2010).…”

Section: Spontaneous Regeneration and Robustnessmentioning

confidence: 99%

Affinity sensor based on immobilized molecular imprinted synthetic recognition elements

Lenain

Saeger

Mattìasson

et al. 2015

Biosensors and Bioelectronics

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Sub-attomolar detection of cholera toxin using a label-free capacitive immunosensor

Cited by 81 publications

References 31 publications

The rational development of molecularly imprinted polymer-based sensors for protein detection

The rational development of molecularly imprinted polymer-based sensors for protein detection

Gold Nanoparticles in Biosensing Analyses

Affinity sensor based on immobilized molecular imprinted synthetic recognition elements

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