Sub-cellular partitioning of metals (Cd, Cu, Zn) in the gills of a freshwater bivalve, Pyganodon grandis: role of calcium concretions in metal sequestration

Bonneris, Emmanuelle; Giguère, Anik; Perceval, Olivier; Buronfosse, Thierry; Masson, Stéphane Le; Hare, Landis; Campbell, Peter G. C.

doi:10.1016/j.aquatox.2004.11.025

Cited by 67 publications

(36 citation statements)

References 37 publications

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“…Lead associated with MRG in mussels Mytilus edulis is thought to be accumulated by endocytosis in a colloidal or particulate form and precipitated as a sulphur or phosphate salt inside the digestive cells as well as in the extracellular compartments (George, 1990). The higher percentage of lead in the MRG fraction in the gill /mantle compared to the hepatopancreas of A. trapezia in this study is in agreement with that found for copper, zinc and cadmium in the freshwater bivalve Pyganodon grandis collected from metal contaminated lakes by Bonneris et al (2005) . These MRG are like ly to be extracellularly bound in the gill filaments or associated with storage in the mantle (Jin g et 01., 2007) and reflect the higher accumulation of lead in the gi ll tissue.…”

Section: Subcellular Lead Distributionsupporting

confidence: 81%

Exposure–dose–response of Anadara trapezia to metal contaminated estuarine sediments. 2. Lead spiked sediments

Taylor

Maher

2012

Aquatic Toxicology

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Section: Subcellular Lead Distributionsupporting

confidence: 81%

Exposure–dose–response of Anadara trapezia to metal contaminated estuarine sediments. 2. Lead spiked sediments

Taylor

Maher

2012

Aquatic Toxicology

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“…In a review of the effects of heavy metals on freshwater mussels, Naimo (1995) observed that, in adult mussels, the most common site of metal uptake is the gill, followed by the mantle and the kidney. According to Bonneris et al (2005b), the presence of calcium concretions in gill tissues was shown to act as sink for metals.…”

Section: Intertissue Differencesmentioning

confidence: 99%

Heavy metal concentrations in the soft tissues of swan mussel (Anodonta cygnea) and surficial sediments from Anzali wetland, Iran

Pourang

Richardson

Mortazavi

2009

Environ Monit Assess

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Concentrations of cadmium, copper, and lead were determined in surficial sediments and the soft tissues (foot and gills) of swan mussel Anodonta cygnea from two sampling sites in Anzali wetland, which is an internationally important wetland registered in the Ramsar Convention. The metal contents in the mussel species from the studied region were comparable to other world areas. In most cases, the levels of the metals either fell within the range for other areas or were lower. There were significant differences between the tissues for the accumulation of Cd and Pb. Only in the case of Pb accumulation in gills significant differences between the specimens from the selected sampling sites could be observed. Age-related correlations were found in the case of Cu accumulation in foot and Cd levels in gills. No weight-dependent trend could be observed for the accumulation of the three elements. There was significant negative width-dependent relationship in the case of Cu. A significant negative correlation was also found between the maximum shell height and Cu accumulation in the gills. The only association among the elements in the selected soft tissues was found between Cd and Pb. Highly significant differences could be found between the sampling sites from the concentration of the elements in sediments point of view. The pattern of metal occurrence in the selected tissues and sediments exhibited the following descending order: Pb, Cu>Cd for gills, Cu>Pb, Cd for foot, and Cu>Pb>Cd for sediments. The mean concentrations of Cd and Pb in the sediments from the study area were higher than the global baseline values and world average shale. In the case of Cu, our results were somewhat higher than the baseline values but well below the world average shale.

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“…Another mechanism for controlling intracellular toxicity of metals is binding with cytosolic proteins (MTLP in soluble fraction S2) (Viarengo and Nott, 1993;Roesijadi, 1992). As the cytosolic metal concentration increases, this causes the metals to bind to the heat-stable fraction S2; this may be indirectly related to the increase of total MTLP concentration induced by high intracellular levels of metals (Bonneris et al 2005), thus confirming the primary role of these proteins in the internal control of metals.…”

Section: Subcellular Distribution Of Metals and Relationship To Mtlpmentioning

confidence: 99%

Temporal variations in metallothionein concentration and subcellular distribution of metals in gills and digestive glands of the oyster <i>Crassostrea angulata</i>

2010

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SUMMARY:The metallothionein levels and metal concentrations in whole body, digestive gland and gills of Crassostrea angulata were analyzed in field samples collected from the River Guadalquivir estuary over several years following a mining waste spill upstream. The subcellular distribution of metals was analyzed to determine the mechanisms involved in the detoxification process. The highest metallothionein levels were reported in the digestive gland shortly after the mining contamination event. In this organ, metals are stored preferentially in the non-cytosolic fraction when increased bioaccumulation takes place. In the cytosol of the gills, metals are associated with metallothionein, whereas in the digestive gland, the distribution of metals between metallothioneins and high molecular weight proteins is similar. Metallothionein variation cannot be explained by metals alone; other abiotic factors must be taken into account. In order to use metallothionein as a metal exposure biomarker in field studies, natural variability needs to be taken into account for the correct interpretation of results.Keywords: metallothionein, metals, subcellular distribution, River Guadalquivir estuary, mining accident, Crassostrea angulata.RESUMEN: Variación temporal de la concentración de metalotioneínas y distribución subcelular de metales en branquias y glándula digestiva del ostron Crassostrea angulata. -Los niveles de metalotioneínas y las concentración de metales en cuerpo total, glándula digestiva y branquias de Crassostrea angulata han sido analizados en muestras de campo recogidas en el estuario del Guadalquivir durante varios años después de un accidente minero. La distribución subcelular de metales se analizó con el fin de conocer los mecanismos implicados en los procesos de detoxificación. Los niveles más elevados de metalotioneínas se hallaron en la glándula digestiva de muestras recogidas después del accidente minero. En este órgano, los metales se almacenan preferencialmente en la fracción no citosólica cuando la bioacumulación aumenta. En el citosol de las branquias, los metales se hallan asociados a las metalotioneínas, mientras que en la glándula digestiva, éstos se encuentran distribuidos de manera similar entre las metalotioneínas y las proteínas de alto peso molecular. La variación de la concentración de metalotioneínas no puede ser explicada sólo en base a las concentraciones de metales, y otros factores abióticos pueden ser responsables del porcentaje de varianza no explicado. Por ello, el empleo de la concentración de metalotioneína como biomarcador de exposición de metales en Crassostrea angulata debe ser considerado con precaución y el conocimiento de la variabilidad natural deber ser tenido en cuenta para una correcta interpretación de los resultados.Palabras clave: metalotioneinas, metales, distribución subcelular, estuario del río Guadalquivir, accidente minero, Crassostrea angulata. Scientia Marina 74S1

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Sub-cellular partitioning of metals (Cd, Cu, Zn) in the gills of a freshwater bivalve, Pyganodon grandis: role of calcium concretions in metal sequestration

Cited by 67 publications

References 37 publications

Exposure–dose–response of Anadara trapezia to metal contaminated estuarine sediments. 2. Lead spiked sediments

Exposure–dose–response of Anadara trapezia to metal contaminated estuarine sediments. 2. Lead spiked sediments

Heavy metal concentrations in the soft tissues of swan mussel (Anodonta cygnea) and surficial sediments from Anzali wetland, Iran

Temporal variations in metallothionein concentration and subcellular distribution of metals in gills and digestive glands of the oyster <i>Crassostrea angulata</i>

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