Sub-chronic safety evaluation of the ethanol extract of Aralia elata leaves in Beagle dogs

Li, Fengjin; He, Xiaoli; Niu, Wenying; Feng, Yuenan; Bian, Jingqi; Kuang, Hai‐Xue; Xiao, Hang

doi:10.1016/j.yrtph.2016.05.005

Cited by 6 publications

(1 citation statement)

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“…Medicinal plants with complex compositions of saponins, flavonoids and alcoloids can cause side-effects or synergic effects over chemical interactions in the organism of animals and humans (Saad, 2006). Therefore, for confirming safety of chemical substances from A. elata for humans, a number of toxicological surveys on experimental animals have been performed, the toxicity and allowable doses of medical preparation for humans have been determined (Li et al, 2015(Li et al, , 2016. On mice, during acute peroral delivery of alcohol tincture (70%), LD 50 was determined to equal 1.25 g/kg (Turova, 1974).…”

Section: Introductionmentioning

confidence: 99%

Effect of alcohol tincture of Aralia elata on the organism of rats and their gut microbiota against the background of excessive fat diet

Brygadyrenko

Lieshchova

Bilan

et al. 2019

Regul. Mech. Biosyst.

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Pharmacological effects of the medicinal plant Aralia elata (Miq.) Seem. 1868 (Araliaceae) are related to presence of over 150 secondary metabolites, including flavonoids, sterols, polysaccharides, terpenoid saponins and terpenoid acids, though the main biologically active substances of A. elata are saponins and flavonoids. Some clinical tests and experimental studies have proved the influence of A. elata on the organism through increase in physical work capacity, exerting an anti-stress effect against a broad range of harmful factors, including stress from cold, immobilization, ultraviolet radiation and low pressure. The literature also reports the anti-ulcer, anti-secretory, antifungal, anti-tumour, and antimicrobial activity of preparations from this plant. In our laboratory experiment, we determined that ethanolic tincture of A. elata has no effect on the intensity of growth of body weight of young rats against the background of excessive content of fat in their diet. Excessive fat-feeding of male rats leads mostly to disorders in the functioning of the liver and development of steatosis. This was accompanied by reduction in relative mass of the liver, increase in activity of hepatic enzymes, dysproteinemia, increase in the level of bilirubin and decrease in the level of urea. Additional use of 0.1% ethanol led to impaired functioning of the kidneys, reduction of their relative mass, signs of dehydration, increase in the level of creatinine and total calcium in the blood. Use of ethanolic tincture of A. elata mitigates negative excess of fat, is accompanied by normalization of indices of mass of the organs, less notable dysproteinemia, impairment in the level of creatinine, glucose, urea, cholesterol, bilirubin and total calcium. Ethanolic tincture of A. elata has a low immunosuppressive action, against the background of a high fat diet it leads to increase in the amount of typical Escherichia сoli, decrease in Еnterococcus spp. and Enterobacter spp., significant decrease and in high concentrations (0.1% ethanolic tincture of A. elata) elimination of bacteria of Clostridium and Klebsiella genera, and also various yeast fungi in the intestine. In the examined male rats, against the background of excess of fat in the diet, no serious changes in the composition of the normal gut microbiota (Bifidobacterium spp., Lactobacillus spp., Proteus spp., Staphylococcus spp., Candida spp.) was observed, nor were any lactose-negative enterobacteria (Citrobacter genus) found. Perspectives of further research include determining histological, histochemical and immune-histological changes in the organs of laboratory animals under the effect of ethanolic tincture of A. elata following excessive accumulation of fat.

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Section: Introductionmentioning

confidence: 99%