Sub-chronic treatment with pioglitazone exerts anti-convulsant effects in pentylenetetrazole-induced seizures of mice: The role of nitric oxide

The involvement of neuronal nitric oxide synthase in the anti-epileptic action of curcumin on pentylenetetrazol-kindled rats

“…A chronic administration of NOS inhibitors or a NO substrate alone did not affect the epileptiform activity, which is a finding that is similar to that produced by other scholars [16].…”

“…In fact, some researchers have suggested that NO is an endogenous anti-convulsant [16], whereas other authors have suggested a pro-convulsant role for NO [17]. Nevertheless, a comprehensive understanding of the role of NO might aid in the development of effective anti-epileptic treatments [19].…”

“…Furthermore, the L-NAME, 7-NI, AG, or L-ARG was administered 15 min before curcumin was injected, and the curcumin was administered 20 min before PTZ was injected. The drug doses that were used in the present study were selected according to previous studies [16][17][18].…”

The influence of ovariectomy on anti-convulsant effect of pioglitazone in mice

“…Antiepileptic efficacy of pioglitazone was reported for the first time by Okada et al [17] in genetically epileptic EL male mice. After that, the anti-convulsant effect of acute and chronic pioglitazone treatment has been revealed in several pentylenetetrazole models in male mice [18][19][20].…”

Atorvastatin attenuates the antinociceptive tolerance of morphine via nitric oxide dependent pathway in male mice

“…The recognized isoforms of NOS are: inducible (iNOS), neuronal (nNOS) and endothelial (eNOS), the last two enzymes are constitutively expressed (Förstermann and Sessa, 2012;Shafaroodi et al, 2012Shafaroodi et al, , 2015. Based upon the previous reports NO and cGMP (cyclic guanosine monophosphate) systems mediate 5 opioid antinociception and tolerace/dependence phenomena (Babey et al, 1994;Elliott et al, 1994;Vaupel et al, 1995).…”