Subacute chlorpyrifos-induced alterations in serum lipids and some oxidative stress biomarkers in male Wistar rats: beneficial effect of acetyl-L-carnitine

Uchendu, Chidiebere; Ambali, Suleiman Folorunsho; Ayo, Joseph Olusegun; Lasisi, Isiaka Olalekan; Umosen, Angela J.

doi:10.1080/02772248.2013.782029

Cited by 10 publications

(9 citation statements)

References 43 publications

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“…Ugbaja et al (2013) affirmed that Pb poisoning induces dyslipidemia and this is capable of predisposing subjects to atherosclerosis. It is posited that the elevated VLDL-c concentration in the CP þ Pb group may be due to the combined hepatotoxic effects of CP (Uzun and Kalender, 2013) and Pb (Thenmozhi et al, 2013), since the synthesis of VLDL-c occurs in the liver (Uchendu et al, 2013). The vulnerability of the liver to toxic assault may preclude it from metabolizing lipids effectively.…”

Section: Discussionmentioning

confidence: 99%

Co-treatment of chlorpyrifos and lead induce serum lipid disorders in rats

et al. 2014

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The aim of this study was to investigate the effects of taurine (TA) on serum lipid profiles following chronic coadministration of chlorpyrifos (CP) and lead acetate (Pb) in male Wistar rats. Fifty rats randomly distributed into five groups served as subjects. Distilled water (DW) was given to DW group, while soya oil (SO; 1 mL kg(-1)) was given to SO group. The TA group was treated with TA (50 mg kg(-1)). The CP + Pb group was administered sequentially with CP (4.25 mg kg(-1); 1/20th median lethal dose (LD50)) and Pb at 233.25 mg kg(-1) (1/20th LD50), while the TA + CP + Pb group received TA (50 mg kg(-1)), CP (4.25 mg kg(-1)), and Pb (233.25 mg kg(-1)) sequentially. The treatments were administered once daily by oral gavage for 16 weeks. The rats were euthanised, and the blood samples were collected at the termination of the study. Sera obtained from the blood samples were analyzed for total cholesterol, high-density lipoprotein cholesterol, triglycerides, and malondialdehyde, and also the activities of serum antioxidant enzymes including superoxide dismutase, catalase and glutathione peroxidase were analyzed. The low-density lipoprotein cholesterol, very-low-density lipoprotein cholesterol, and atherogenic index were calculated. The results showed that CP and Pb induced alterations in the serum lipid profiles and evoked oxidative stress. TA alleviated the disruptions in the serum lipid profiles of the rats partially by mitigating oxidative stress. It was concluded that TA may be used for prophylaxis against serum lipid disorders in animals that were constantly co-exposed to CP and Pb in the environment.

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Section: Discussionmentioning

confidence: 99%

Co-treatment of chlorpyrifos and lead induce serum lipid disorders in rats

et al. 2014

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“…HDL is synthesized mainly in the liver and it facilitates cholesterol efflux from tissues to the liver for removal as bile acids [37]. In contrast toreports on organophosphates where the lipoprotein concentration was increased [38,27], HDL level was slightly depressed by DDVP exposure in this study. On the other hand, diabetic rats displayed a significant decrease in HDL-C below that of the control, a level that was not changed by DDVP exposure.Taking into account the increased levels of VLDL and phospholipids in the present study, the low concentration of HDL-C in diabetes could be contributed by the increased hepatic secretion of VLDL resulting from rapid free fatty acid flux to the liver [39,40].…”

Section: Discussionmentioning

confidence: 48%

Dichlorvos Exposure Aggravates Complications Associated with Diabetes in Wistar Rats

2016

International Journal of Research Studies in Biosciences

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“…Apart from the direct inhibition of AChE, oxidative stress has also been implicated in many pathologies caused by CPF (Uchendu et al, 2013). AChE is a membrane-bound enzyme and lipoperoxidation of the membrane causes a decrease in its activity (Uchendu et al, 2013). This may be responsible for the decrease in AChE activity seen in the CC group in the present study.…”

Section: Discussionmentioning

confidence: 50%

“…Significant reduction in AChE activity in the rats' brain has been linked to oxidative stress (Tsakiris et al, 2000). Apart from the direct inhibition of AChE, oxidative stress has also been implicated in many pathologies caused by CPF (Uchendu et al, 2013). AChE is a membrane-bound enzyme and lipoperoxidation of the membrane causes a decrease in its activity (Uchendu et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Ameliorative effects of melatonin on brain biochemical changes induced by subchronic co-administration of chlorpyrifos and cypermethrin in male Wistar rats

Idris¹,

Ambali²,

Сулейман³

2017

J. Toxicol. Environ. Health Sci.

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The present study was aimed at evaluating the ameliorative effects of melatonin on chlorpyrifos and cypermethrin induced brain biochemical changes involving malonadialdehyde (MDA), catalase, superoxide dismutase, glutathione peroxidise and acetyl cholinesterase in male Wistar rats. The fifty adult male Wistar rats used for this study were divided into 5 groups of 10 animals each. Group I was administered distilled water, group II was given soya oil (2 ml/kg), group III was given melatonin (0.5 mg/kg), group IV was given chlorpyrifos (7.94 mg/kg-1/10th LD 50) and cypermethrin (29.6 mg/kg-1/10th LD 50), and group V was pretreated with melatonin (0.5 mg/kg) and then 30 min later, chlorpyrifos (7.94 mg/kg-1/10th LD 50) and cypermethrin (29.6 mg/kg-1/10th LD 50). The regimens were administered by gavage once daily for a period of 12 weeks. Increased MDA concentrations, decreased catalase, superoxide dismutase, glutathione peroxidise, and acetylcholinesterase activities were recorded in the group IV, however, these changes were ameliorated by melatonin. Therefore, it was concluded that melatonin mitigated chlorpyrifos and cypermethrin induced brain biochemical changes due to its antioxidant properties.

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Subacute chlorpyrifos-induced alterations in serum lipids and some oxidative stress biomarkers in male Wistar rats: beneficial effect of acetyl-L-carnitine

Cited by 10 publications

References 43 publications

Co-treatment of chlorpyrifos and lead induce serum lipid disorders in rats

Co-treatment of chlorpyrifos and lead induce serum lipid disorders in rats

Dichlorvos Exposure Aggravates Complications Associated with Diabetes in Wistar Rats

Ameliorative effects of melatonin on brain biochemical changes induced by subchronic co-administration of chlorpyrifos and cypermethrin in male Wistar rats

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