Subacute cutaneous lupus erythematosus presenting in twins

Montuno, Michael A.; Church, Ann; Schoch, Jennifer J.; Andrews, Israel D.

doi:10.1111/pde.13434

Cited by 2 publications

(4 citation statements)

References 26 publications

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“…It was observed that 10%-15% of SCLE patients developed mild systemic organ symptoms. [3][4][5] The common differential diagnosis of rash is polymorphic light eruption, drug photosensitivity, and tinea corporis. 6…”

Section: Introductionmentioning

confidence: 99%

“…Skin lesions of SCLE can be triggered by several drugs such as terbinafine, dapsone, protease inhibitors, thiazide diuretics, allylamine antifungals, angiotensin‐converting enzyme inhibitors, and calcium channel blockers, also with ultraviolet (UV) exposure and smoking. It was observed that 10%‐15% of SCLE patients developed mild systemic organ symptoms 3‐5 . The common differential diagnosis of rash is polymorphic light eruption, drug photosensitivity, and tinea corporis 6 …”

Section: Introductionmentioning

confidence: 99%

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Alendronate induced subacute cutaneous lupus erythematosus successfully treated with intravenous immunoglobulin

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Dermatologic Therapy

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The subacute cutaneous lupus erythematosus (SCLE) is a distinct subtype of lupus erythematosus (LE) representing specific clinical and serological features. Almost 20%-30% of the cases with SCLE are predicted to associated with medications. Thiazide diuretics, terbinafine, antiepileptic, and proton pump inhibitors are the bestknown drugs to induce drug-related SCLE. Herein we want to present a 65-year-old female with alendronate induced SCLE, resistant to classical therapies, and respond well to intravenous immunoglobulin (IVIG), suggesting that IVIG could be an alternative treatment in patients resistant to classical treatment protocols.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Alendronate induced subacute cutaneous lupus erythematosus successfully treated with intravenous immunoglobulin

Uzunçakmak

Bayazit

Aşkın

et al. 2020

Dermatologic Therapy

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“…ANAs are frequently present, but patients typically have anti‐SS‐A (Ro) antibodies. Approximately half of patients with SCLE fulfil the criteria for systemic lupus erythematosus (SLE) . Our patient was diagnosed as having SCLE associated with mild transaminitis.…”

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confidence: 96%

“…Only a few childhood SCLE cases have been reported in literature, including one child from India . Patients with SCLE usually present with photodistributed, erythematous, nonscarring lesions, associated with mild systemic symptoms such as musculoskeletal problems.…”

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Childhood subacute cutaneous lupus erythematosus associated with transaminitis

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symptoms, history, computed tomography and magnetic resonance imaging (MRI). Anti-NXP2 antibodies were detected using an in-house ELISA.Five of the patients with DM were positive for anti-NXP2 antibodies. The clinical and laboratory findings are summarized in Table 1. All five anti-NXP2-positive patients had facial erythema, and two (Patients 1 and 2) of them had subcutaneous inflammation.Patient 1 was a 37-year-old woman, who presented with erythema, swelling, pain and oedema of the left lower thigh. A punch biopsy of the erythematous plaque from the left lower thigh (Fig. 1a) revealed panniculitis with predominantly lymphocytic inflammatory infiltrates in the subcutaneous fat (Fig. 1b).Patient 2 was a 67-year-old woman, who presented with a 2-month history of muscle pain and of erythema on her face, neck, limbs and back. She had undergone gastrectomy for stomach cancer at 64 years old. Shorttau inversion recovery MRI showed subcutaneous inflammation underlying her upper-arm erythema (Fig. 1c,d).A recent study 3 on the cutaneous characteristics of 20 patients with anti-MJ/NXP2-positive myositis showed that patients with anti-MJ/NXP2 positivity frequently had peripheral oedema (35% P = 0.02) and calcinosis (37% P < 0.01). Although facial rash was frequently observed in that report, the anti-MJ/NXP2-negative group also frequently showed facial rash (80% vs. 82%, P = 0.52). 3 The recent paper by Chairatchaneeboon et al. reviewed 25 reported cases of DM-associated panniculitis, in which 20 cases were described with pathological panniculitis features. 4 Of these 20 cases with a description of the pathological features, 7 had calcinosis and 11 had a lobular panniculitis as the dominant panniculitis. Unfortunately, our punch biopsy pathology sample (Patient 1) was too small to identify a definite pattern of panniculitis. Recently, an interesting anti-MJ/NXP2-positive DM case was published, in which panniculitis around the calcinosis sites was detected by biopsy and fluorodeoxyglucose-positron emission tomography. 5 In our study, Patient 3 presented with calcinosis 12 years after DM onset. Anti-MJ/NXP2 antibody in patients with DM seems to be associated with frequent subcutaneous involvement, such as oedema and calcinosis. 3 Calcinosis is possibly caused by both chronic and strong subcutaneous inflammation, including panniculitis.

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Subacute cutaneous lupus erythematosus presenting in twins

Cited by 2 publications

References 26 publications

Alendronate induced subacute cutaneous lupus erythematosus successfully treated with intravenous immunoglobulin

Alendronate induced subacute cutaneous lupus erythematosus successfully treated with intravenous immunoglobulin

Childhood subacute cutaneous lupus erythematosus associated with transaminitis

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