Subacute Sclerosing Panencephalitis Causing Rapidly Progressive Dementia
                        and Myoclonic Jerks in a Sexagenarian Woman

Reyes, Antonio Jose; Ramcharan, Kanterpersad; Perot, Sean; Giddings, Stanley; Rampersad, Fidel; Gobin, Reanna

doi:10.5334/tohm.480

Cited by 4 publications

(4 citation statements)

References 14 publications

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“…By no means is this list completely inclusive, but it speaks to a vast realm of possibilities that should be considered in addition to subacute sclerosing panencephalitis. 18,20,[25][26][27]…”

Section: Differential Diagnosismentioning

confidence: 99%

Pediatric Subacute Sclerosing Panencephalitis: A Narrative Review on Measles and the Future of Vaccination

Sulaiman,

Vora,

Chhabra

et al. 2024

J Child Neurol

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Subacute sclerosing panencephalitis is a rare complication due to persistent measles infection, characterized by cognitive and motor deterioration. Because subacute sclerosing panencephalitis is considered a potentially fatal complication of measles and usually presents in young populations, particularly those with measles infection under the age of 2 years, new approaches to implement vaccination programs must be devised to help avoid the worsening of patient outcome. Until the disease is eradicated globally, children in all regions of the world remain at risk of measles infection and its respective complications, and therefore, the vaccine is considered the optimal preventative measure. The legacy of measles virus goes beyond the immediate complications. Our study, therefore, aims to provide a comprehensive review on the updated insights into subacute sclerosing panencephalitis as a complication, as well as the extent and future considerations pertaining to vaccination programs in the pediatric population.

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Section: Differential Diagnosismentioning

confidence: 99%

Pediatric Subacute Sclerosing Panencephalitis: A Narrative Review on Measles and the Future of Vaccination

Sulaiman,

Vora,

Chhabra

et al. 2024

J Child Neurol

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“…Mostly affecting children, the virus causes neurodegeneration, inflammation, and demyelination of the central nervous system resulting in death before the age of three. Although rare, it has been noticed in older adults where SSPE remerges from a dormant state and causes dementia [162].…”

Section: Subacute Sclerosing Panencephalitismentioning

confidence: 99%

Multiple Causes of Dementia as Engineered Senescence

Garrett

2020

EJMED

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All traumas—cranial, cardiovascular, hormone, viral, bacterial, fungi, parasites, misfolded protein, genetic, behavior, environmental and medication—affect the brain. This paper itemizes studies showing the many different causes of dementia including Alzheimer’s disease. Causes interact with each other, act sequentially by preparing the optimal conditions for its successor, initiate other diseases, allow for other traumas to accumulate and degrade protective features of the brain. Since such age-related cognitive impairment is not exclusively a human attribute there might be support for an evolutionary theory of dementia. Relying on theories of antagonistic pleiotropy and polymorphism, the brain has been designed to sequester trauma. Because of increased longevity, the short-term tactic of sequestering trauma becomes a long-term liability. We are engineered to sequester these insults until a tipping point is reached. Dementia is an evolutionary trade-off for longevity. We cannot cure dementia without understanding the overall biology of aging.

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“…Reyes and colleagues reported a 62-year-old woman who presented with rapidly progressive dementia and myoclonus and was later diagnosed as having SSPE. 4 This is one of the three oldest recorded patients with SSPE. There are two additional earlier reports of SSPE where patients presented after the age of 60 years.…”

mentioning

confidence: 96%

“…MRI consistently demonstrated T2 hyperintensities in the periventricular region, predominantly affecting the occipitoparietal lobes (Table 1). 4–14 Creutzfeldt–Jakob disease and anti- N -methyl- d -aspartate-receptor encephalitis are often close differential diagnoses. The demonstration of elevated CSF antimeasles antibody titer and brain biopsy helps in establishing the diagnosis of SSPE.…”

mentioning

confidence: 99%