Subambient Behavior of Mannitol in Ethanol–Water Co-solvent System

Takada, Akira; Nail, Steven L.; Yonese, Masakatsu

doi:10.1007/s11095-008-9775-0

Cited by 8 publications

(3 citation statements)

References 18 publications

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“…The shelf was cooled from ambient temperature to −50°C at a rate of 0.5°C/min and maintained at −50°C for 30 min. For cycles with an annealing step, 60 min of annealing was inserted into the freezing process at −20°C for aqueous solutions and at −30°C for ethanol-containing solutions, referring to our previous study (23). In addition, two methods of primary drying were carried out, one for the aqueous solutions and one for the ethanolcontaining solutions.…”

Section: Freeze-dryingmentioning

confidence: 99%

Influence of Ethanol on Physical State of Freeze-Dried Mannitol

2009

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Section: Freeze-dryingmentioning

confidence: 99%

Influence of Ethanol on Physical State of Freeze-Dried Mannitol

2009

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“…Ethanol is one of the typical organic solvents highly miscible with water, also it is classified in Class 3 of ICH guidelines and residual ethanol in finished product has a low safety risk [8]. The increased solubility with the addition of ethanol is most likely due to the formation of hydration shell around the MMC that acts as a compatible layer between the drug and ethanol [9].…”

Section: Introductionmentioning

confidence: 99%

Surface wetting driven release of antifibrotic Mitomycin-C drug from modified biopolymer thin films

Takács

Abdelghafour

Deák

et al. 2020

European Polymer Journal

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We demonstrate that Nature-inspired lotus-like non-wetting phenomena can also be used in the field of controlled drug delivery. Hydrophobically modified, and cellulose microparticle-roughened polyvinyl alcohol (PVA) biopolymer based thin films were synthetised and converted into superhydrophobic (Θ=165.3°; [[EQUATION]] = 1.7±0.67 mJ/m 2 ) thin films. The surface wetting of the thin films was adjustable from superhydrophilic to superhydrophobic nature and this affected the drug release properties as well. We also prove that this surface wetting driven drug delivery system (DDS) is suitable for the encapsulation and prolonged/ adjusted release of Mitomycin (MMC), a drug with antifibrotic properties. The in vitro release experiments conducted under physiological conditions (PBS, pH = 7.4) revealed that -due to the lower crystallinity-the release of MMC was faster (k'=6.1×10 -6 mM/s) from the hydrophilic film compared to the pure, crystalline (k'=1.21×10 -6 mM/s) MMC. Neverteless, significantly lower MMC dissolution rate (k'=5×10 -8 mM/s) was obtained for the superhydrophobic sample featuring a non-wetting, lotus-like nature. Based on this in vitro study, we suggest that the presented surface wetting driven DDS loaded with MMC could be useful for example in the area of head and neck surgeries to prevent scar tissue formation.

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“…The most commonly used methods for the dehydration of ethanol are distillation, extraction, molecular sieve adsorption, and pervaporation . In the pharmaceutical industry, ethanol–water mixtures, as cosolvent systems, have been evaluated in order to increase drug solubility, because the solubility of many drugs in pure water is very low and residual ethanol in the finished product imposes a low safety risk . Studies of the solubility of many pharmaceutical compounds such as mitomycin C , L‐glutamine , sulphapyridine , and so on, have been recently published.…”

Section: Introductionmentioning

confidence: 99%

Study of the desorption of hydrolysed reactive dyes from cotton fabrics in an ethanol–water solvent system

Hang

2013

Coloration Technology

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The factors influencing the desorption of hydrolysed dyes resulting from reactive cotton dyeings in an ethanol–water solvent system, including the volume ratio of ethanol to water, pH, and temperature, were investigated. The maximum desorption was achieved when the volume ratio of ethanol to water was optimised to 4:6. Desorption increased with an increase in pH and temperature. The kinetic curves of dye desorption at three different temperatures fit a two‐step kinetic model. The dye desorbability at 60 °C in an ethanol–water system was similar to that observed using conventional water washing in the presence of detergent at 95 °C. Findings suggest that wash‐off in an ethanol–water system can be considered as an alternative, more effective process for removing hydrolysed dyes from reactive cotton dyeings.

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Subambient Behavior of Mannitol in Ethanol–Water Co-solvent System

Abstract: In the presence of ethanol, crystallization of mannitol was inhibited under subambient conditions. Annealing or slower cooling promoted the crystallization of mannitol during the freezing process.

Cited by 8 publications

References 18 publications

Influence of Ethanol on Physical State of Freeze-Dried Mannitol

Influence of Ethanol on Physical State of Freeze-Dried Mannitol

Surface wetting driven release of antifibrotic Mitomycin-C drug from modified biopolymer thin films

Study of the desorption of hydrolysed reactive dyes from cotton fabrics in an ethanol–water solvent system

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