Subarachnoid pharmacotherapy for maximizing recovery after cortical ischemic stroke

An Electrocorticography Device with an Integrated Microfluidic Ion Pump for Simultaneous Neural Recording and Electrophoretic Drug Delivery In Vivo

“…Implants that do not penetrate the brain are in many cases preferable to brain‐penetrating ones, as the latter cause more tissue damage and increase risk for the patient. To that end, there have been multiple devices designed for drug delivery within the intracranial space between brain and skull including gels and tablets that release drugs as they dissolve and various systems that allow for fluidic injection of drugs . However, fluidic drug injection systems have been plagued by problems with clogging and reflux while the single‐use nature of dissolving implants is not well suited for the treatment of chronic disorders.…”