Subcellular Organelle Toxicity Caused by Arsenic Nanoparticles in Isolated Rat Hepatocytes

Jahangirnejad, Rashid; Goudarzi, Mehdi; Kalantari‬, Heibatullah; Najafzadeh, Hossein; Rezaeian, Mohsen

doi:10.15171/ijoem.2020.1614

Cited by 13 publications

(10 citation statements)

References 50 publications

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“…Furthermore, a one-week exposure of silver nanoparticles caused significant reduction in TECs and Hct% in silver carp [47]. AsNPs have been reported to induce apoptosis in hepatocytes [48].…”

Section: Discussionmentioning

confidence: 94%

Toxicity Evaluation of Arsenic Nanoparticles on Growth, Biochemical, Hematological, and Physiological Parameters of Labeo rohita Juveniles

Raza

Kanwal

Shahid

et al. 2021

Advances in Materials Science and Engineering

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The present study aims to assess the induced nanotoxicity of arsenic nanoparticles (AsNPs) on different organs of fresh water fish Labeo rohita. AsNPs were synthesized by chemical reduction method using sodium arsenite as precursor, ice-cold sodium borohydride as reducing agent, and sodium hydroxide to adjust the solution pH. The synthesized AsNPs were characterized by UV-Vis spectroscopy, X-ray diffraction (XRD), and scanning electron microscopy (SEM) for optical, structural, and morphological investigations. The UV-Vis absorption peaks occurring at around 300 nm indicated the presence of AsNPs in colloidal sample. The rhombohedral crystalline nature and metallic purity of AsNPs with crystallite size of 30 ± 1 nm were confirmed by characteristic peaks of XRD pattern. The SEM micrograph revealed the almost spherical shape and 40 ± 10 nm average size prepared AsNPs. For assessment of induced nanotoxicity, juveniles of Labeo rohita (L. rohita) were exposed to three different concentrations of AsNPs (namely, 1, 10, and 20 mg/L) for 30 days (n = 15 per group), and the control fish was kept untreated. It was observed that the routine behavior activities (such as swimming, mutual interactions, and feed intake) were affected by AsNPs. The growth of AsNPs treated fish was found retarded as compared to the control fish. Total erythrocyte count, total leukocyte count, and hemoglobin and hematocrit values were low in the AsNPs treated fish. Immunobiochemical assays revealed that protein level was altered in the AsNPs treated fish. The levels of antioxidant enzymes catalase and superoxide dismutase were low in the treated fish. The histological alteration induced by AsNPs in liver, gills, and kidneys demonstrated the damage in form of glomerulus shrinkage, vacuolation, inflammation, necrosis, lamellar disorganization, and hemorrhage in comparison with untreated fish. The results of the present study indicate that AsNPs exposure causes behavior, growth, hematology, immunobiochemical, and histological shortcomings in L. rohita.

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Section: Discussionmentioning

confidence: 94%

Toxicity Evaluation of Arsenic Nanoparticles on Growth, Biochemical, Hematological, and Physiological Parameters of Labeo rohita Juveniles

Raza

Kanwal

Shahid

et al. 2021

Advances in Materials Science and Engineering

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“…Despite the lower sensitivity of organelles to biofuels, they are very sensitive to toxins. 17 For example, lysosomes are inhibited by a wide range of toxins especially arsenic 229 and cadmium. 230 So, inhibition-based biosensors can be designed based on the toxicity to organelles and reduction of electricity generation.…”

Section: Sensorsmentioning

confidence: 99%

Advancements in Bio-inspired Self-Powered Wireless Sensors: Materials, Mechanisms, and Biomedical Applications

Farzin,

Naghib,

Rabiee

2024

ACS Biomater. Sci. Eng.

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The rapid maturation of smart city ecosystems is intimately linked to advances in the Internet of Things (IoT) and self-powered sensing technologies. Central to this evolution are battery-less sensors that are critical for applications such as continuous health monitoring through blood metabolites and vital signs, the recognition of human activity for behavioral analysis, and the operational enhancement of humanoid robots. The focus on biosensors that exploit the human body for energy-spanning wearable, attachable, and implantable variants has intensified, driven by their broad applicability in areas from underwater exploration to biomedical assays and earthquake monitoring. The heart of these sensors lies in their diverse energy harvesting mechanisms, including biofuel cells, and piezoelectric, triboelectric, and pyroelectric nanogenerators. Notwithstanding the wealth of research, the literature still lacks a holistic review that integrates the design challenges and implementation intricacies of such sensors. Our review seeks to fill this gap by thoroughly evaluating energy harvesting strategies from both material and structural perspectives and assessing their roles in powering an array of sensors for myriad uses. This exploration offers a comprehensive outlook on the state of self-powered sensing devices, tackling the nuances of their deployment and highlighting their potential to revolutionize data gathering in autonomous systems. The intent of this review is to chart the current landscape and future prospects, providing a pivotal reference point for ongoing research and innovation in selfpowered wireless sensing technologies.

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“…It was also shown that the toxic concentration of different NPs accompanied by oxidative stress may disrupt the structure of the lysosomal membrane. The liberation of the lysosomal inner content to the cytosol, due to its membrane damage, could induce further damage of other organelles (especially the mitochondrial outer membrane) and further activate apoptosis [34,37,38]. In this regard, the use of antioxidants regulating ROS production seems a promising therapeutic strategy for NP-induced toxicity.…”

Section: The Mechanism Of Nanoparticle Toxicitymentioning

confidence: 99%

An Overview of the Beneficial Role of Antioxidants in the Treatment of Nanoparticle‐Induced Toxicities

Mihailović

Stanković

Selaković

et al. 2021

Oxidative Medicine and Cellular Longevity

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Nanoparticles (NPs) are used in many products and materials for humans such as electronics, in medicine for drug delivery, as biosensors, in biotechnology, and in agriculture, as ingredients in cosmetics and food supplements. Besides that, NPs may display potentially hazardous properties on human health and the environment as a consequence of their abundant use in life nowadays. Hence, there is increased interest of researchers to provide possible therapeutic agents or dietary supplements for the amelioration of NP-induced toxicity. This review summarizes the new findings in the research of the use of antioxidants as supplements for the prevention and alleviation of harmful effects caused by exposure of organisms to NPs. Also, mechanisms involved in the formation of NP-induced oxidative stress and protective mechanisms using different antioxidant substances have also been elaborated. This review also highlights the potential of naturally occurring antioxidants for the enhancement of the antioxidant defense systems in the prevention and mitigation of organism damage caused by NP-induced oxidative stress. Based on the presented results of the most recent studies, it may be concluded that the role of antioxidants in the prevention and treatment of nanoparticle-induced toxicity is unimpeachable. This is particularly important in terms of oxidative stress suppression.

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Subcellular Organelle Toxicity Caused by Arsenic Nanoparticles in Isolated Rat Hepatocytes

Cited by 13 publications

References 50 publications

Toxicity Evaluation of Arsenic Nanoparticles on Growth, Biochemical, Hematological, and Physiological Parameters of Labeo rohita Juveniles

Toxicity Evaluation of Arsenic Nanoparticles on Growth, Biochemical, Hematological, and Physiological Parameters of Labeo rohita Juveniles

Advancements in Bio-inspired Self-Powered Wireless Sensors: Materials, Mechanisms, and Biomedical Applications

An Overview of the Beneficial Role of Antioxidants in the Treatment of Nanoparticle‐Induced Toxicities

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