Subchromosomal anomalies in small for gestational-age fetuses and newborns

Ma, Ying; Pei, Yan; Yin, Chenghong; Jiang, Yuxin; Wang, Jingjing; Li, Xiaofei; Li, Lin; Kagan, Karl Oliver

doi:10.1007/s00404-019-05235-4

Cited by 9 publications

(15 citation statements)

References 24 publications

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“…Genetic causes are suspected, based on well‐described associations between chromosomal and morphological anomalies in humans and mice, including specific disorders of the neural tube and CVS 13,33‐35 . Further, a relationship of a small embryonic/fetal size and structural anomalies with subchromosomal pathologies was recently found 36 and chromosomal 13,33‐36 and teratogenic causes, such as maternal diabetes, 37 are known to be meaningful for pregnancy outcome in various species.…”

Section: Discussionmentioning

confidence: 99%

Fetal morphological features and abnormalities associated with equine early pregnancy loss

Kahler

McGonnell

Smart

et al. 2020

Equine Veterinary Journal

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Section: Discussionmentioning

confidence: 99%

Fetal morphological features and abnormalities associated with equine early pregnancy loss

Kahler

McGonnell

Smart

et al. 2020

Equine Veterinary Journal

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“…In addition, women should be counselled about the risk of a genetic etiology even in the presence of “isolated” FGR (i.e. without associated fetal anomalies) 37,270,283‐285 . A recent meta‐analysis of 10 studies found that in cases of isolated FGR, chromosomal microarray had an incremental yield of 4% (95% CI, 1%–6%) over karyotyping: 17 of 376 fetuses with isolated FGR and normal karyotype had significant findings in microarray, most commonly 22q11.2 duplication, Xp22.3 deletion, and 7q11.23 deletion.…”

Section: What Kind Of Investigations Should Be Performed When Fetal Gmentioning

confidence: 99%

“…37,270,[283][284][285] A recent meta-analysis of 10 studies found that in cases of isolated FGR, chromosomal microarray had…”

mentioning

confidence: 99%

FIGO (International Federation of Gynecology and Obstetrics) initiative on fetal growth: Best practice advice for screening, diagnosis, and management of fetal growth restriction

Melamed

Baschat

Yinon

et al. 2021

Intl J Gynecology & Obste

286

218

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“…IVIM was helpful to improve the diagnosis of placental dysfunction. A 6.8-11.4% increase of chromosomal abnormalities at karyotyping was demonstrated in SGA patients at full-term compared to normal infants (7,10,11). Ruan Peng et al reported the chromosomal and sub-chromosomal anomalies associated to SGA fetuses (10).…”

Section: Introductionmentioning

confidence: 99%

“…Some clinical research has demonstrated that reduced size at birth may result from fetal, maternal, and/or placental factors (5)(6)(7). However, it is still currently difficult during the perinatal period, to predict precisely which child will have short stature at 2 years of age.…”

Section: Introductionmentioning

confidence: 99%

Risk Factors for Short Stature in Children Born Small for Gestational Age at Full-Term

et al. 2022

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ObjectiveThis study aims to identify the risk factors associated with short stature in children born small for gestational age (SGA) at full-term.MethodsThis was a retrospective study. The subjects were full-term SGA infants who were followed up until the age of 2 years. The risk factors for short stature were identified with univariate and multivariate analyses.ResultsOf 456 full-term SGA children enrolled in this study, 28 cases had short stature at 2 years of age. A significant decrease in placental perfusion was found in the short children group with intravoxel incoherent motion (IVIM) technology, which was an advanced bi-exponential diffusion-weighted imaging (DWI) model of magnetic resonance imaging (MRI) (p = 0.012). Compared to non-short children born SGA at full-term, the short children group underwent an incomplete catch-up growth. Mothers who suffered from systemic lupus erythematosus were more likely to have a short child born SGA (p = 0.023). The morbidity of giant placental chorioangioma was higher in the short children group. The pulsatility index (PI), resistivity index (RI), and systolic-diastolic (S/D) ratio of umbilical artery were higher in the short children group than in the non-short control group (p = 0.042, 0.041, and 0.043). Multivariate analysis demonstrated that decrease of perfusion fraction (fp) in IVIM of placental MRI, chromosomal abnormalities, short parental height, and absence of catch-up growth were associated with a higher risk of short stature in children born SGA at full-term.ConclusionRisk factors for short stature in full-term SGA children at 2 years of age included a decrease of perfusion fraction fp in IVIM of placental MRI, chromosomal abnormalities, and short parental height.

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Subchromosomal anomalies in small for gestational-age fetuses and newborns

Cited by 9 publications

References 24 publications

Fetal morphological features and abnormalities associated with equine early pregnancy loss

Fetal morphological features and abnormalities associated with equine early pregnancy loss

FIGO (International Federation of Gynecology and Obstetrics) initiative on fetal growth: Best practice advice for screening, diagnosis, and management of fetal growth restriction

Risk Factors for Short Stature in Children Born Small for Gestational Age at Full-Term

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