Subchronic stress-induced depressive behavior in ovariectomized mice

Nakagawasai, Osamu; Oba, Akira; Sato, Atsushi; Arai, Yasuhiko; Mitazaki, Satoru; Onogi, Hiroshi; Wakui, Kenji; Niijima, Fukie; Tan-No, Koichi; Tadano, Takeshi

doi:10.1016/j.lfs.2009.01.009

Cited by 15 publications

(17 citation statements)

References 38 publications

(36 reference statements)

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“…Measurement of Locomotor Activity-The locomotor activity was measured by using an Animex Auto MK-110 (Muromachi Kikai Co., Ltd., Tokyo, Japan), as described previously (25). Briefly, each mouse was placed at top of an Animex, which is an activity cage.…”

Section: Methodsmentioning

confidence: 99%

α1,6-Fucosyltransferase-deficient Mice Exhibit Multiple Behavioral Abnormalities Associated with a Schizophrenia-like Phenotype

Fukuda

Hashimoto

Okayasu

et al. 2011

Journal of Biological Chemistry

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Previously, we reported that ␣1,6-fucosyltransferase (Fut8)-deficient (Fut8 ؊/؊ ) mice exhibit emphysema-like changes in the lung and severe growth retardation due to dysregulation of TGF-␤1 and EGF receptors and to abnormal integrin activation, respectively. To study the role of ␣1,6-fucosylation in brain tissue where Fut8 is highly expressed, we examined Fut8 ؊/؊ mice using a combination of neurological and behavioral tests. ␣1,6-Fucosyltransferase (Fut8) 2 catalyzes the transfer of a fucose residue from GDP-fucose to position 6 of the innermost GlcNAc residue to form ␣1,6-fucose in hybrid and complex N-linked oligosaccharides of glycoproteins as shown in Fig. 1 (1). ␣1,6-Fucosylated glycoproteins are widely distributed in mammalian tissues, especially in the brain (2). In fact, the majority of N-glycans present in mouse brain tissue are ␣1,6-fucosylated (3). We recently investigated the physiological functions of ␣1,6-fucose by using Fut8-deficient (Fut8 Ϫ/Ϫ ) mice (4). Fut8 Ϫ/Ϫ mice showed severe growth retardation. They also suffered from emphysema-like changes in their lungs that appeared to be due to a lack of ␣1,6-fucosylation of the transforming growth factor-␤1 (TGF-␤1) receptor, which consequently resulted in dysregulation of TGF-␤1 receptor activation and signaling (4), and down-regulation of expression of vascular endothelial cell growth factor receptor-2 (5). In addition, deletion of the core fucose from the IgG1 molecule reportedly enhances antibody-dependent cellular cytotoxicity activity by 50 -100-fold. This result indicates that ␣1,6-fucose is an important sugar chain in terms of antibody-dependent cellular cytotoxicity activity (6). Moreover, the loss of ␣1,6-fucosylation down-regulates both EGF receptor-mediated cell signaling pathways (7) and integrin ␣3␤1-mediated cell adhesion (8). Taken together, these results suggest that ␣1,6-fucose plays a key role in regulating important physiological functions via modification of functional proteins.Complex N-glycans are required for the development of the embryo, and the complete lack of N-glycans in GnT-I-deficient mice is lethal with defects in neural tube formation (9). These observations suggest that high-mannose N-glycans are insufficient for normal ontogeny. On the other hand, restriction of N-glycan branching to the formation of only hybrid structures by GnT-II inactivation in mice results in a very low rate of * This work was supported by Scientific Research Grants-in-aid 21370059 (to J. G.) and 22590071 (to T. F.) from the Japan Society for the Promotion of Science and the Academic Frontier Project for Private Universities from the Ministry of Education, Culture, Sports, Science and Technology of Japan. 1 To whom correspondence should be addressed. Tel.: 81-22-727-0216; Fax:81-22-727-0078; E-mail: jgu@tohoku-pharm.ac.jp.2 The abbreviations used are: Fut8, ␣1,6-fucosyltransferase; PPI, prepulse inhibition; TGF-␤1, transforming growth factor-␤1; GnT-III, N-acetylglucosaminyltransferase III; GnT-V, N-acetylglucosaminyltransferase V; 5-HT, 5-h...

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Section: Methodsmentioning

confidence: 99%

α1,6-Fucosyltransferase-deficient Mice Exhibit Multiple Behavioral Abnormalities Associated with a Schizophrenia-like Phenotype

Fukuda

Hashimoto

Okayasu

et al. 2011

Journal of Biological Chemistry

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“…Additionally, Nakagawasai et al (2009) demonstrated that ovariectomized ddY mice presented no alterations on the duration of immobility time in the FST. Neurochemical studies suggest that brain neural networks might be different among these inbred animals.…”

Section: Introductionmentioning

confidence: 98%

“…Furthermore, genetic factors and sex differences among these mouse strains could also contribute to the differences observed in the baseline immobility (Barros and Ferigolo 1998;Urani et al 2005). Conversely, Nakagawasai et al (2009) reported that a combination of OVX and subchronic stress caused a significant prolongation of immobility time in the FST in ddY female mice compared to nonovariectomized ones.…”

Section: Introductionmentioning

confidence: 99%

“…Methods using acute stressors, as restraint stress, rely on the ability of an acute stressor to produce behavioral changes (depressive-like effect) that are reversible by antidepressant treatment (Poleszak et al 2006). In this sense, literature data provided evidence that the association of OVX and subchronic stress exposure in rodents (subchronic restraint-water immersion for example) is an effective method for studying the development and treatment of affective disorders (Nakagawasai et al 2009). …”

Section: Introductionmentioning

confidence: 99%

“…In view of this fact, previous unpublished data from our research group provided evidence that OVX did not affect the duration of immobility time of female Swiss mice in the FST. Considering that we intended to use ovariectomy as an animal model of menopause, we used the subchronic stress exposure protocol according to Nakagawasai et al (2009) in order to generate a depressive-like state (prolongation of the immobility time) in OVX Swiss mice. For this reason, in order to justify this type of experimental procedure scientifically and ethically, a time-course analysis of the restraint-water immersion stress-induced depressivelike behavior and the restraint stress-induced depressive-like behavior (without water immersion) was accomplished.…”

Section: Introductionmentioning

confidence: 99%

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