Subclinic arterial and left ventricular systolic impairment in autosomal dominant polycystic kidney disease with preserved renal functions

Cardiovascular Manifestations and Management in ADPKD

“…It should be noted that LVH is a structural finding and does not accurately reflect cardiac function, particularly in those patients without other manifestations of CVD. 112 Therefore, the assessment of cardiac function should accompany investigations for LVH, including echocardiographic determination of ejection fraction and possible inclusion of newer methods to detect cardiac strain, such as 2-dimensional strain or global longitudinal strain. 112 , 113 Furthermore, there are studies reporting increased cardiac strain in patients with ADPKD (detected by increased left ventricular global longitudinal strain on echocardiography) with normal ejection fractions and preserved kidney function.…”

“… 112 Therefore, the assessment of cardiac function should accompany investigations for LVH, including echocardiographic determination of ejection fraction and possible inclusion of newer methods to detect cardiac strain, such as 2-dimensional strain or global longitudinal strain. 112 , 113 Furthermore, there are studies reporting increased cardiac strain in patients with ADPKD (detected by increased left ventricular global longitudinal strain on echocardiography) with normal ejection fractions and preserved kidney function. 112 , 114 This subclinical sign of cardiac dysfunction is associated with decreased functional capacity (measured by 6-minute walk and timed up and go tests) and quality of life in CKD; however, further evaluation in ADPKD populations are required to determine its predictive long-term risk.…”

“… 112 , 113 Furthermore, there are studies reporting increased cardiac strain in patients with ADPKD (detected by increased left ventricular global longitudinal strain on echocardiography) with normal ejection fractions and preserved kidney function. 112 , 114 This subclinical sign of cardiac dysfunction is associated with decreased functional capacity (measured by 6-minute walk and timed up and go tests) and quality of life in CKD; however, further evaluation in ADPKD populations are required to determine its predictive long-term risk. 113 , 115 …”

Assessment of Cardiovascular Disease in Autosomal Dominant Polycystic Kidney Disease

“…Specific cardiac abnormalities related to mutations of PC1 and PC2 have not been reported, but all valvular apparatuses are involved in this condition; the most reported valvular defects are mitral valve prolapse, mitral incompetence, and tricuspid valve prolapse. Regardless of other possible causes, these abnormalities are more frequent in affected patients than in the general population [16][17][18][19][20]. According to the study by Lumiaho A. et al, mitral valve prolapse occurs in 26% of patients with PKD1, 14% of unaffected relatives, and 10% of control subjects [16].…”