Background The sarcopenia quality-of-life (SarQoL)® questionnaire is a multidimensional sarcopenia specific tool designed for community dwelling older adults. Aims The aim of this study was to translate, to cross-culturally adapt and validate the SarQoL® questionnaire to assess sarcopenia-related quality of life in Turkish older adults. Methods The validation process was performed in two sections: the first section constituted the translation with cross-cultural adaptation of SarQoL® into Turkish. Second section constituted the clinical validation study. To validate the Turkish version of the SarQoL®, we assessed its validity (discriminative power, construct validity), reliability (internal consistency, test-retest reliability) and floor/ceiling effects. Results One hundred community-dwelling subjects (mean age: 74.7 ± 6.1 years) were evaluated. The EWGSOP2 consensus diagnostic criteria were used to diagnose probable sarcopenia. A database including 1437 older adults, with complete evaluation of sarcopenia parameters, served to define low global muscle function. Results revealed a good discriminative power: subjects with probable sarcopenia had higher total scores compared to non-sarcopenic subjects (50 ± 16 vs. 68.9 ± 16.9, p < 0.001) a high internal consistency (Cronbach's alpha: 0.88), consistent construct validity and excellent test-retest reliability (intraclass correlation coefficient: 0.97, 95% confidence interval: 0.94-0.98). There was no floor/ceiling effect. ConclusionThe Turkish version of the SaQoL® questionnaire was found to be reliable and valid for the measurement of quality of life of sarcopenic patients and is, therefore, available for use in clinical research and practice. This validation could enable use of the SarQoL® tool in the eastern populations more confidently.

No abstract

No abstract

Objective:The term "polypharmacy" is defined as the usage of multiple medications or more medications than are clinically indicated. Older people tend to have several chronic diseases and prescriptions for these conditions. Polypharmacy is associated with significant consequences such as adverse drug reactions, medication nonadherence, drug-drug and drug-disease interactions, and increased risk of geriatric syndromes. The purpose of the present study was to evaluate the relationship between polypharmacy and common geriatric syndromes. Materials and Methods:Three-hundred individuals ≥60 years of age admitted to İstanbul Faculty of Medicine, Department of Geriatrics outpatient clinic between 2013-2016 were recruited to the study. Patients' data about the number of prescribed drugs, falls (in the preceding year), urinary incontinence, constipation, presence of malnutrition, sleep disorders and functionality were noted. Polypharmacy was defined as the usage of four or more medications. Results:The study was consisted of 198 (66.8%) women and 102 (33.2%) men with mean age of 76.5±6.7 years. The prevalence of polypharmacy was 82.7%. Univariate and multivariate analysis were performed to examine the relationship between polypharmacy and other geriatric syndromes. In regression analysis, polypharmacy was found to be independently associated with sleep disorders [Odds ratio (OR): 2.21, 95% Confidence interval (CI): 1.15-4.24, p=0.016] and urinary incontinence (OR: 2.53, 95% CI: 1.21-5.27, p=0.013). Conclusion:Polypharmacy is an important health problem among older adults, which is frequently associated with inappropriate medication use, increased risk of adverse drug reactions, and poor health outcomes. In this study, sleep disorders and urinary incontinence were found to be independently associated with polypharmacy. Clinicians should consider polypharmacy and related risks when prescribing medications for older adults. AbstractCite this article as: Küçükdağlı P. Polypharmacy and

No abstract