Subclinical cerebrovascular disease in NAFLD without overt risk factors for atherosclerosis

Cognitive Dysfunction in Non-Alcoholic Fatty Liver Disease—Current Knowledge, Mechanisms and Perspectives

“…In a large study of 505 individuals, NAFLD was associated with lower total and grey matter CBF after adjusting for cardiovascular risk factors, but not after adjustment for BMI [117]. Findings of reduced CBF have been reproduced in smaller studies of biopsy-proven NAFLD [118], and one particular study found NAFLD patients to have impaired upregulation of cerebral blood volume measured by oxygenated haemoglobin concentration during a cognitively challenging verbal fluency task [39].…”

Изменения Сосудов Головного Мозга У Пациентов С Неалкогольной Жировой Болезнью Печени И Нарушением Углеводного Обмена

“…In addition, NAFLD was associated with a higher risk of atherosclerosis in large vessels [15]. Another study (L. Airaghi et al, 2018) also examined subclinical cerebrovascular lesions in patients with NAFLD, but without risk factors for atherosclerosis [16].…”

Nonalcoholic Fatty Liver Disease

“…Furthermore, NAFLD-associated endothelial dysfunction and the procoagulant state were linked to the same microvascular alterations, which may contribute to disturbances in brain circulation, damage, and cognitive impairment (Lombardi et al 2019). Besides the link to the aforementioned cerebrovascular diseases (Airaghi et al 2018), other brain-related associations have been established to NAFLD. Firstly, a recent report from Horwath et al demonstrated that endoplasmic reticulum stress in the subfornical organ of the brain, a brain region previously linked to appetite (Matsuda et al 2017), directly mediated hepatic steatosis, thereby directly linking the brain to the liver in the context of NAFLD.…”