Subclinical Hypothyroidism

Biondi, Bernadette; Duntas, Leonidas

doi:10.1007/978-3-319-72102-6_18

Cited by 6 publications

(2 citation statements)

References 63 publications

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“…TSH is the main index of thyroid function and is of great significance in the detection of thyroid function. [ 13 , 14 ] However, in PCOS, the ligand specifically binds to cell membranes or intracellular receptors. After the ligand binds to the receptor, a series of proteins in the cell gradually regulate the activity of downstream proteins, gradually amplifying and transmitting signals from the outside.…”

Section: Discussionmentioning

confidence: 99%

Correlation between serum thyroid stimulating hormone level and glycolipid metabolism in patients with polycystic ovary syndrome

Chen,

Jing,

Sun

2023

Medicine

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To investigate the correlation between serum thyroid-stimulating hormone (TSH) levels and glycolipid metabolism in patients with polycystic ovary syndrome (PCOS). From January 2021 to November 2022, 105 patients with PCOS were selected for this retrospective study. All patients were administered drug-induced ovulation treatment and were divided into 2 groups according to ovulation status. There were 67 and 38 patients in the ovulation and non-ovulation groups, respectively. Venous blood (5 mL) was collected on the day after admission from the non-ovulation group and on the day of physical examination from the ovulation group. Several indicators were measured, including TSH, fasting plasma glucose (FPG), glycosylated hemoglobin, total cholesterol (TC), high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglyceride (TG), albumin (ALB), prealbumin (PA), and transferrin (TF). Weight, BMI, waistline, and hipline in the non-ovulation group were significantly higher than those in the ovulation group (P < .05). There were no significant differences in glycosylated hemoglobin, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol levels between the non-ovulation and ovulation groups (P > .05). Compared with the ovulation group, the levels of TSH, FPG, TC, and TG in the non-ovulation group were significantly higher (P < .05). Serum ALB, PA, and TF the non-ovulation group were significantly higher than those in the ovulation group (P < .05). Correlation analysis showed that TSH was negatively correlated with weight, BMI, waistline, hipline, waist-hip ratio, FPG, ALB, PA, and TF in the non-ovulation group (P < .05) and had no significant correlation with TC and TG (P > .05). Our findings demonstrate TSH levels may be associated with weight, BMI, waistline, hipline, waist-hip ratio, FPG, ALB, PA, and TF in patients with PCOS.

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Section: Discussionmentioning

confidence: 99%

Correlation between serum thyroid stimulating hormone level and glycolipid metabolism in patients with polycystic ovary syndrome

Chen,

Jing,

Sun

2023

Medicine

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“…Studies have reported an incidence rate of 22–29% for radiotherapy-related thyroid dysfunction 8 , 9 . Thyroid dysfunction can manifest as fatigue, cold intolerance, dry skin, weight gain, constipation, or it can be asymptomatic, exerting varying degrees of impact on patients’ social function and quality of life 10 . Minimizing the occurrence of radiation-induced thyroid dysfunction has become a crucial consideration in the treatment strategy for nasopharyngeal carcinoma patients and remains one of the hot topics that need to be addressed.…”

Section: Introductionmentioning

confidence: 99%

A machine learning approach for predicting radiation-induced hypothyroidism in patients with nasopharyngeal carcinoma undergoing tomotherapy

Quan,

Lin,

Hong

et al. 2024

Sci Rep

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The purpose of this study was to establish an integrated predictive model that combines clinical features, DVH, radiomics, and dosiomics features to predict RIHT in patients receiving tomotherapy for nasopharyngeal carcinoma. Data from 219 patients with nasopharyngeal carcinoma were randomly divided into a training cohort (n = 175) and a test cohort (n = 44) in an 8:2 ratio. RIHT is defined as serum thyroid-stimulating hormone (TSH) greater than 5.6 μU/mL, with or without a decrease in free thyroxine (FT4). Clinical features, 27 DVH features, 107 radiomics features and 107 dosiomics features were extracted for each case and included in the model construction. The least absolute shrinkage and selection operator (LASSO) regression method was used to select the most relevant features. The eXtreme Gradient Boosting (XGBoost) was then employed to train separate models using the selected features from clinical, DVH, radiomics and dosiomics data. Finally, a combined model incorporating all features was developed. The models were evaluated using receiver operating characteristic (ROC) curves and decision curve analysis. In the test cohort, the area under the receiver operating characteristic curve (AUC) for the clinical, DVH, radiomics, dosiomics and combined models were 0.798 (95% confidence interval [CI], 0.656–0.941), 0.673 (0.512–0.834), 0.714 (0.555–0.873), 0.698 (0.530–0.848) and 0.842 (0.724–0.960), respectively. The combined model exhibited higher AUC values compared to other models. The decision curve analysis demonstrated that the combined model had superior clinical utility within the threshold probability range of 1% to 79% when compared to the other models. This study has successfully developed a predictive model that combines multiple features. The performance of the combined model is superior to that of single-feature models, allowing for early prediction of RIHT in patients with nasopharyngeal carcinoma after tomotherapy.

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L-Thyroxin bei Hypothyreose – absetzen oder nicht?

Kramer,

Bleckwenn,

Deutsch

et al. 2024

Z Allg Med

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Zusammenfassung Hintergrund L‑Thyroxin ist eines der am häufigsten verordneten Arzneimittel in Deutschland. Es wird hauptsächlich zur Behandlung der Hypothyreose eingesetzt. Aufgrund von Verordnungsdaten ist davon auszugehen, dass L‑Thyroxin häufiger verordnet wird als es medizinisch indiziert ist. Ziel der Arbeit Sind hausärztlich Tätige bereit, Dosisreduktionen oder Absetzversuche von L‑Thyroxin vorzunehmen? Methodik Auf der Jahrestagung der Sächsischen Gesellschaft für Allgemeinmedizin erfolgte eine Querschnittserhebung mittels Fragebogen. Dieser beinhaltete 3 konstruierte Fälle, deren L‑Thyroxin-Therapie auf Änderungspotenzial zu bewerten war. Es erfolgte eine deskriptive Analyse der quantitativen Daten sowie eine qualitative Inhaltsanalyse. Ergebnisse Insgesamt nahmen 33 hausärztlich Tätige an der Befragung teil. Am häufigsten wurde eine Beibehaltung der Dosis oder sogar eine Dosiserhöhung favorisiert. Dies wurde mit guter Therapieeinstellung, mutmaßlich fehlendem Nachteil einer geringen Dosis oder der Vermeidung von Komplikationen begründet. Selten wurde eine Reduktion oder ein Absetzen vorgeschlagen. Für das Absetzen oder Dosisreduktion wurde sich mit Verweis auf die fehlende medizinische Indikation ausgesprochen. Diskussion Auch bei fehlender medizinischer Indikation waren die Teilnehmenden zurückhaltend, eine bestehende Therapie zu verändern. Dies deckt sich mit Angaben aus der existierenden Literatur. Die Annahme der Vermeidung von Folgeerkrankungen, begrenzte Zeit für Beratungsgespräche und mangelnde Kommunikation zwischen Verordnenden wurden in anderen Studien als Ursachen identifiziert. Dabei gibt es Hinweise auf den Nutzen von Deprescribing. Es besteht diesbezüglich im deutschen primärärztlichen Bereich noch großer Forschungsbedarf.

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Subclinical Hypothyroidism

Cited by 6 publications

References 63 publications

Correlation between serum thyroid stimulating hormone level and glycolipid metabolism in patients with polycystic ovary syndrome

Correlation between serum thyroid stimulating hormone level and glycolipid metabolism in patients with polycystic ovary syndrome

A machine learning approach for predicting radiation-induced hypothyroidism in patients with nasopharyngeal carcinoma undergoing tomotherapy

L-Thyroxin bei Hypothyreose – absetzen oder nicht?

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