Subcorneal Pustular Dermatosis in a Patient with Hyperthyroidism

Taniguchi, Shoji; Tsuruta, D.; Kutsuna, Haruo; Hamada, Takahiro

doi:10.1159/000246638

Cited by 20 publications

(9 citation statements)

References 10 publications

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“…These include connective tissue diseases, inflammatory bowel disease, hypothyroidism, hyperthyroidism, SAPHO (synovitis, acne, pustulosis, hyperostosis, osteitis) syndrome, and multiple sclerosis [5,14,15,[23][24][25][26].…”

Section: Inflammatory and Connective Tissue Diseasesmentioning

confidence: 99%

Subcorneal Pustular Dermatosis: A Review of 30 Years of Progress

2016

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Subcorneal pustular dermatosis (SPD), also known as Sneddon-Wilkinson disease, is a rare, benign yet relapsing pustular dermatosis. Its incidence and prevalence have not been well studied. It characteristically presents as hypopyon pustules on the trunk and intertriginous areas of the body. SPD is similar to two other disease entities. Both SPD-type immunoglobulin (Ig)-A pemphigus and annular pustular psoriasis clinically and histologically present similarly to SPD. Immunologic studies separate SPD-type IgA pemphigus from SPD and pustular psoriasis. However, there is still an unclear designation as to whether SPD is its own entity distinct from pustular psoriasis, as the once thought characteristic histologic picture of psoriasis does not hold true for pustular psoriasis. SPD has been reported to occur in association with several neoplastic, immunologic, and inflammatory conditions. Dapsone remains the first-line treatment for SPD, although dapsone-resistant cases have been increasingly reported. Other therapies have been used singly or as adjunctive therapy with success, such as corticosteroids, immunosuppressive agents, tumor necrosis factor inhibitors, and ultraviolet light therapy. This article provides a review of the last 30 years of available literature, with a focus on successful treatment options and a suggestion for reappraisal of the classification of SPD.

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Section: Inflammatory and Connective Tissue Diseasesmentioning

confidence: 99%

Subcorneal Pustular Dermatosis: A Review of 30 Years of Progress

2016

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“…They can develop both before and after the diagnosis of SCPD. There are also anecdotal reports in association with mycoplasma pneumoniae respiratory infection, 7 seronegative and seropositive rheumatoid arthritis, 8 hypothyroidism and hyperthyroidism, 9 systemic lupus erythematosis, Sjogren’s syndrome 10 , Crohn’s disease, 11 multiple sclerosis 12 and SAPHO 13 (synovitis, acne, pustulosis, hyperostosis, osteitis) syndrome. One report described two cases of SCPD that developed at 10 and 12 h after echocardiography was performed 14 .…”

Section: Associationsmentioning

confidence: 99%

Subcorneal pustular dermatosis: 50 years on

et al. 2008

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We review the key developments in our understanding of subcorneal pustular dermatosis (SCPD, also known as Sneddon-Wilkinson disease) over the past 50 years. SCPD is a rare, chronic, sterile pustular eruption that was first described by Sneddon and Wilkinson in 1956. The primary lesions are pea-sized pustules classically described as half-pustular, half-clear flaccid fluid blisters. Histologically the salient feature is a subcorneal accumulation of neutrophils, suggesting the presence of chemoattractants such as tumour necrosis factor (TNF)alpha in the uppermost epidermis. However, to date its exact pathophysiology is unknown. Cases in association with pyoderma gangrenosum, benign monoclonal IgA gammopathy and multiple myeloma are well documented. There are anecdotal reports of SCPD associated with other internal malignancies such as chronic lymphocytic leukaemia, thymoma, apudoma and epidermoid carcinoma of the lung. The treatment of choice is dapsone. Therapeutic alternatives include retinoids, phototreatment with psoralen ultraviolet (UV) A, broadband or narrow band UVB and corticosteroids. Anecdotal uses of tacalcitol, ketoconazole, azithromycin, tetracycline, minocycline, vitamin E, ciclosporin, colchicine, mizoribine, mebhydrolin, infliximab and adalimumab with mycophenolate mofetil have all been reported.

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“…There are well-documented SCPD in associations with benign monoclonal IgA gammopathy [10] and pyoderma gangrenosum [11]. There are also reports in association with IgA myeloma [3], SAPHO syndrome [12], Crohn's disease [13], Sjogren's syndrome [14], rheumatoid arthritis [15], and thyroidal diseases [16]. …”

Section: Discussion and Reviewmentioning

confidence: 99%

Subcorneal Pustular Dermatosis in Childhood: A Case Report and Review of the Literature

Scalvenzi

Palmisano

Annunziata

et al. 2013

Case Reports in Dermatological Medicine

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Subcorneal pustular dermatosis (SCPD, also known as Sneddon-Wilkinson disease) is a rare, benign, chronic, sterile pustular eruption which usually develops in middle-age or elderly women; it is rarely seen in childhood and adolescence. The primary lesions are pea-sized pustules classically described as half-pustular, half-clear flaccid blisters. Histologically the most important feature is a subcorneal accumulation of neutrophils with the absence of spongiosis or acantholysis, although acantholysis may be reported in older lesions. In this paper we present the case of a 7-year-old boy diagnosed with SCPD based on the characteristic clinical and histological features. Dapsone has been successfully used in the treatment of the disease.

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Subcorneal Pustular Dermatosis in a Patient with Hyperthyroidism

Cited by 20 publications

References 10 publications

Subcorneal Pustular Dermatosis: A Review of 30 Years of Progress

Subcorneal Pustular Dermatosis: A Review of 30 Years of Progress

Subcorneal pustular dermatosis: 50 years on

Subcorneal Pustular Dermatosis in Childhood: A Case Report and Review of the Literature

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