Subcortical Intermittent Theta-Burst Stimulation (iTBS) Increases Theta-Power in Dorsolateral Prefrontal Cortex (DLPFC)

Bentley, J. Nicole; Irwin, Zachary T.; Black, Sarah D.; Roach, Megan L.; Vaden, Ryan J.; Gonzalez, Christopher L.; Khan, Anas U.; Elsayed, Galal; Knight, Robert T.; Guthrie, Barton L.; Walker, Harrison C.

doi:10.3389/fnins.2020.00041

Cited by 23 publications

(18 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…While these studies show mixed findings for trait stability, they suggest a potential for CSP and LICI to be used as markers of treatment response with certain medications as it shows modulation with pharmacological agents. TMS is also a non-invasive procedure with high tolerability (166,167), making it ideal for the use of identification of endophenotypes and/or predictive markers.…”

Section: Tms-emg and Tms-eeg Paradigmsmentioning

confidence: 99%

Neurophysiological Biomarkers in Schizophrenia—P50, Mismatch Negativity, and TMS-EMG and TMS-EEG

2020

View full text Add to dashboard Cite

Impaired early auditory processing is a well characterized finding in schizophrenia that is theorized to contribute to clinical symptoms, cognitive impairment, and social dysfunction in patients. Two neurophysiological measures of early auditory processing, P50 gating ("P50") and mismatch negativity (MMN), which measure sensory gating and detection of change in auditory stimuli, respectively, are consistently shown to be impaired in patients with schizophrenia. Transcranial magnetic stimulation (TMS) may also be a potential method by which sensory processing can be assessed, since TMS paradigms can be used to measure GABA B-mediated cortical inhibition that is linked with sensory gating. In this review, we examine the potential of P50, MMN and two TMS paradigms, cortical silent period (CSP) and long-interval intracortical inhibition (LICI), as endophenotypes as well as their ability to be used as predictive markers for interventions targeted at cognitive and psychosocial functioning. Studies consistently support a link between MMN, P50, and cognitive dysfunction, with robust evidence for a link between MMN and psychosocial functioning in schizophrenia as well. Importantly, studies have demonstrated that MMN can be used to predict performance in social and cognitive training tasks. A growing body of studies also supports the potential of MMN to be used as an endophenotype, and future studies are needed to determine if MMN can be used as an endophenotype specifically in schizophrenia. P50, however, has weaker evidence supporting its use as an endophenotype. While CSP and LICI are not as extensively investigated, growing evidence is supporting their potential to be used as an endophenotype in schizophrenia. Future studies that assess the ability of P50, MMN, and TMS neurophysiological measures to predict performance in cognitive and social training programs may identify markers that inform clinical decisions in the treatment of neurocognitive impairments in schizophrenia.

show abstract

Section: Tms-emg and Tms-eeg Paradigmsmentioning

confidence: 99%

Neurophysiological Biomarkers in Schizophrenia—P50, Mismatch Negativity, and TMS-EMG and TMS-EEG

2020

View full text Add to dashboard Cite

show abstract

“…Prior studies translating rTMS paradigms to intraparenchymal stimulation showed varying or weak results [21,23], or did not report neurophysiological changes [36]. For example, Keller et al (2018) stimulated several different brain regions across patients and found mixed excitation at some treatment locations and inhibition at others.…”

Section: Discussionmentioning

confidence: 99%

“…Since we characterized the physiological effects of cortical iTBS in the human sensorimotor cortex the obvious question is about the generalizability of the results. A recent DBS study in PD patients applied subcortical iTBS to the globus pallidus internus (GPi) and the subthalamic nucleus (STN) while recording from the DLPFC [23]. They found that GPi stimulation (but not STN) modulated theta power in DLPFC, suggesting that iTBS can be effectively applied to other brain areas and cause frequency-specific effects (see also [60]).…”

Section: Discussionmentioning

confidence: 99%

“…A potential explanation of the heterogenous effects is that stimulation was applied across several different functional regions across patients. Additionally, the authors used intermittent alpha burst stimulation while the most efficient protocol to induce increases in neural excitability uses intermittent theta burst stimulation (iTBS, brief bursts of 50-100Hz pulses repeated at 5 Hz) [18,[22][23][24][25][26][27][28]).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Enhancing neuronal plasticity through intracranial theta burst stimulation in the human sensorimotor cortex

Herrero

Smith

Mishra

et al. 2021

Preprint

View full text Add to dashboard Cite

The progress of therapeutic neuromodulation greatly depends on improving stimulation parameters to most efficiently induce neuroplasticity effects. Intermittent Theta Burst stimulation (iTBS), a form of electrical stimulation that mimics the natural brain activity patterns, has shown efficacy in inducing such effects in animal studies and rhythmic Transcranial Magnetic Stimulation (rTMS) studies in humans. However, little is known about the potential neuroplasticity effects of iTBS applied through intracranial electrodes in humans which could have implications for deep brain stimulation therapies. This study characterizes the physiological effects of cortical iTBS in the human cortex and compare them with single pulse alpha stimulation, another frequently used paradigm in rTMS research. We applied these stimulation paradigms to well-defined regions in the sensorimotor cortex which elicited contralateral hand or arm muscle contractions during electrical stimulation mapping in epilepsy patients implanted with intracranial electrodes. Treatment effects were evaluated using effective connectivity and beta oscillations coherence measures in areas connected to the treatment site as defined with cortico-cortical evoked potentials. Our results show that iTBS increases beta band synchronization within the sensorimotor network indicating a potential neuroplasticity effect. The effect is specific to the sensorimotor system, the beta frequency band and the stimulation pattern (no effect was found with single-pulse alpha stimulation). The effects outlasted the stimulation by three minutes. By characterizing the neurophysiological effects of iTBS within well-defined cortical networks, we hope to provide an electrophysiological framework that allows clinicians and researchers to optimize brain stimulation protocols which may have translational value.

show abstract

“…-remains a largely unanswered question. One recent study examined whether deep brain TBS of the basal ganglia yielded immediate change in cortical oscillations, nding that dorsolateral prefrontal (DLPFC) theta power increased following less than 30 seconds of intermittent theta-burst stimulation 21 . However, this study does not offer a full accounting of how intracranial TBS may in uence neural activity across a range of recording locations and stimulation frequencies.…”

Section: Introductionmentioning

confidence: 99%

Theta-burst stimulation entrains frequency-specific oscillatory responses

Solomon

Sperling

Sharan

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: Brain stimulation has emerged as a powerful tool in human neuroscience, becoming integral to next-generation psychiatric and neurologic therapeutics. Theta-burst stimulation (TBS), in which electrical pulses are delivered in rhythmic bouts of 3-8 Hz, seeks to recapitulate neural activity seen endogenously during cognitive tasks. A growing literature suggests that TBS can be used to alter or enhance cognitive processes, but little is known about how these stimulation events influence underlying neural activity.Objective/Hypothesis: The goal of our study was to investigate the effect of direct electrical TBS on mesoscale neural activity in humans by asking (1) whether TBS evokes persistent theta oscillations in cortical areas, (2) whether these oscillations occur at the stimulated frequency, and (3) whether stimulation events propagate in a manner consistent with underlying functional and structural brain architecture.Methods: We recruited 20 neurosurgical epilepsy patients with indwelling electrodes and delivered direct cortical TBS at varying locations and frequencies. Simultaneous iEEG was recorded from non-stimulated electrodes and analyzed to understand how TBS influences mesoscale neural activity. Results: We found that TBS rapidly evoked theta rhythms in widespread brain regions, preferentially at the stimulation frequency, and that these oscillations persisted for hundreds of milliseconds post stimulation offset. Furthermore, the functional connectivity between recording and stimulation sites predicted the strength of theta response, suggesting that underlying brain architecture guides the flow of stimulation through the brain.Conclusions: By demonstrating that direct TBS induces frequency-specific oscillatory responses, our results suggest this technology can be used to directly and predictably influence the activity of cognitively-relevant brain networks.

show abstract

Subcortical Intermittent Theta-Burst Stimulation (iTBS) Increases Theta-Power in Dorsolateral Prefrontal Cortex (DLPFC)

Cited by 23 publications

References 67 publications

Neurophysiological Biomarkers in Schizophrenia—P50, Mismatch Negativity, and TMS-EMG and TMS-EEG

Neurophysiological Biomarkers in Schizophrenia—P50, Mismatch Negativity, and TMS-EMG and TMS-EEG

Enhancing neuronal plasticity through intracranial theta burst stimulation in the human sensorimotor cortex

Theta-burst stimulation entrains frequency-specific oscillatory responses

Contact Info

Product

Resources

About