Subcutaneous Dirofilariosis in South‐East Serbia‐Case Report

Tasić, S.; Stoiljkovic, Nenad; Miladinović-Tasić, Nataša; Tasić, Aleksandar; Mihailović, D.; Rossi, Luca; Gabrielli, Simona; Cancrini, Gabriella

doi:10.1111/j.1863-2378.2010.01379.x

Cited by 16 publications

(10 citation statements)

References 22 publications

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“…According to Džamić et al (2009), until 2008 a total of 28 cases had been reported of which 19 occurred in the period from 2001 to 2008. The southernmost reports on human dirofilariosis are from Vranje and Prizren where the patients had worms in the subconjunctival and periocular tissues (Tasić et al, 2011;Jakšić et al, 2011). A recent study has shown that seroreactivity to D. repens antigens was found in 29 out of 297 people examined (9.8%) from 7 different areas of Serbia (Tasić-Otašević et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…Besides, some researchers suggest that wild carnivores such as foxes may be significant wild reservoirs for zoonotic filarioids (Magi et al, 2008). With an exception of a few studies on the presence of microfilariae in the blood of domestic dogs (Tasić et al, 2008(Tasić et al, , 2012Kočevski et al, 2010) and human dirofilariosis case reports (Stefkov and Gjorgov, 1967;Cvetković et al, 2007;Džamić et al, 2009;Tasić et al, 2011;Jurhar Pavlova et al, 2012), no research has been conducted so far on wild animals, either in Serbia or in the Former Yugoslav Republic of Macedonia. The aim of this study was to present the first data on D. repens in wild canids from the Central Balkan and to help understand the importance of these species as hosts and potential reservoirs of dirofilariosis in nature.…”

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confidence: 99%

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First records of Dirofilaria repens in wild canids from the region of Central Balkan

Ćirović

Penezić

Pavlović

et al. 2014

Acta Veterinaria Hungarica

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Dirofilaria repens causes an emerging zoonotic disease in Europe, particularly in its southern part, the Mediterranean region. Many reports on human dirofilariosis have been published recently, but little is known about the wildlife hosts and reservoirs of this parasite in nature. This paper presents the first records of adult D. repens specimens from free-ranging carnivores in Central Balkan countries (Serbia and Macedonia). During the period 2009-2013, a total of 145 regularly shot canids were examined for the presence of D. repens adults. In order to investigate their role as hosts and potential wild reservoirs of this zoonosis, 71 wolves (Canis lupus), 48 foxes (Vulpes vulpes) and 26 jackals (Canis aureus) were examined. Under the skin of two wolves (one from Serbia and one from Macedonia) and of a red fox from Serbia D. repens adults were found. In all three cases only one parasite was present. Further research on wild canids is needed, particularly on species widening their range (such as jackals) and those living near human settlements (foxes and jackals), which facilitates the transmission of the parasites to dogs and humans.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

First records of Dirofilaria repens in wild canids from the region of Central Balkan

Ćirović

Penezić

Pavlović

et al. 2014

Acta Veterinaria Hungarica

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“…By this epidemiological evidence in dogs, many cases of human infection should be expected, but instead, only about 30 cases have been reported to date [3,14]. This apparent disagreement urged us to investigate the actual frequency of infectious contacts between the two filarial parasites and human population, and to analyze possible risk factors for the infection, which would be useful in planning the appropriate control strategies.…”

Section: Introductionmentioning

confidence: 99%

Seroreactivity to Dirofilariaantigens in people from different areas of Serbia

Otašević

Gabrielli

Tasić³

et al. 2014

BMC Infect Dis

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BackgroundThe Northern part of Serbia is hyperendemic-endemic for canine dirofilarioses. Considering this fact, many human dirofilarial infections could be expected, however only about 30 cases in Serbia have been described until today. Aims of this survey were to assess the people reactivity to the antigens of D. repens and D. immitis and to identify risk factors for the contact exposure.MethodsInvestigation included sera taken from 297 people (179 women and 118 men) living in different areas of Serbia (Pančevo, Novi Sad, Zaječar, Leskovac, Vranje, Niš, Pirot). Sera were analysed by means of two indirect enzyme-linked immunosorbent (ELISA) home-designed that use as antigens adult somatic/metabolic polyproteins of D. repens (DR) and D. immitis (DI), respectively. The results were elaborated using the statistical method of descriptive and quantitative analysis.ResultsSignificant differences by area in the reactivity of human sera to dirofilarial antigens were not observed (p = 0.056). A high seroreactivity was demonstrated in people from the towns of northern Serbia (Pančevo = 27,1%; Novi Sad = 16,3%), as well as in people from Zaječar (eastern Serbia = 15,8%) and Vranje (southern Serbia = 15,1%). No differences were evidenced between people reactivity to polyproteins of the two dirofilarial species, nor differences related to the gender of examinees. Factor risks evidenced were: i) place of residence; ii) spending work time outdoors during the mosquito season; iii) spending time outdoors and nearby rivers, lakes, swamps or canals; unespectedly, iv) cat owning.ConclusionThe findings emerging from this investigation indicate that clinicians and public health authorities should pay greater attention to this zoonosis. Continuing education and training of physicians will greatly contribute to the knowledge of the actual impact of filarial worms on animal and public health, and allow for the planning of suitable measures to prevent the infections.

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“…This is the first case of the human ocular, subconjunctival dirofilariosis on the territory of the southeast Serbia and the city of Niš. Note that in this case there was no history of patient's trips or stay in other parts of Serbia, such as Vojvodina which is considered as a hyperendemic area for D. repens in dogs (16,(20)(21)(22)(23)(24).…”

Section: Discussionmentioning

confidence: 99%

Subconjunctival Infection due to Dirofilaria Repens ‐Case Report

Božinović¹,

Tomasevic²,

Gabrielli³

et al. 2014

Acta Facultatis Medicae Naissensis

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ACTA FACULTATIS MEDICAE NAISSENSIS UDC:616.995.132:617.7 S U M M A R YThe aim of the survey was to present the clinical course and surgical treatment of the first case of human ocular dirofilariosis on the territory of the city of Niš, in the southeast Serbia.Male patient, 57 years old, visited an ophthalmologist because of extreme swelling and redness of the eyelids of the right eye, scratches and pain in his right eye. On standard examination on biomicroscope, temporally 3 mm from the limbus, intrapalpebrally, a mobile parasite was observed in the subconjunctival space. Complete extraction of the living parasites, 13 cm long, was performed. A sample of the nematode based on morphological and morphometric characteristics was identified as Dirofilaria repens-like. The diagnosis was confirmed with molecular methods.For ocular dirofilariosis, surgical methods and complete extraction of the parasite are the only ways to achieve complete recovery.

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Subcutaneous Dirofilariosis in South‐East Serbia‐Case Report

Cited by 16 publications

References 22 publications

First records of Dirofilaria repens in wild canids from the region of Central Balkan

First records of Dirofilaria repens in wild canids from the region of Central Balkan

Seroreactivity to Dirofilariaantigens in people from different areas of Serbia

Subconjunctival Infection due to Dirofilaria Repens ‐Case Report

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