Subcutaneous “growths” in monkeys produced by a Poxvirus

Titration and Extensive Serial Passages of Yaba Virus In Vitro

“…HeLa cells were revealed to be refractile to VV infection as has already been reported by some workers [1,16]. The difference of the suscept- [16,17].…”

“…The virus belongs to the poxvirus group [2,16] and infects Asiatic monkeys [1,7,16] and man [1,7,8] almost exclusively. Attempts to infect usual experimental animals with YV have been unsuccessful [1,16,17].…”

“…The virus belongs to the poxvirus group [2,16] and infects Asiatic monkeys [1,7,16] and man [1,7,8] almost exclusively. Attempts to infect usual experimental animals with YV have been unsuccessful [1,16,17]. Recently, Strandstrom et al [18] reported that YV could be propagated in embryonated hen eggs, although conflicting reports have been made [1,2,16].…”

“…Attempts to infect usual experimental animals with YV have been unsuccessful [1,16,17]. Recently, Strandstrom et al [18] reported that YV could be propagated in embryonated hen eggs, although conflicting reports have been made [1,2,16].…”

Serological evidence of infection with Tana and Yaba pox viruses among several species of monkey

“…Yaba virus has also been shown to be pathogenic for man on experimental infection and one accidental infection in a laboratory technician has been reported (Grace & Mirand, 1963). On epidemiological grounds it has been suggested that African monkeys are the natural hosts of both viruses (Niven et al 1961;Schmidt, 1970;Downie et al 1971). The two viruses, although similar in morphology, produce lesions in monkeys which are clinically and histologically different, the lesions of Yaba viruses being large tumour-like masses involving mainly mesodermal tissues while Tanapox virus produces superficial hyperplastic nodules affecting almost entirely epithelial cells.…”