Subcutaneous Panniculitis-like T-cell Lymphoma: Review of Therapies

S, Thakur A Chaudhari; Chaudhari, Thakur M

doi:10.4172/2165-8048.1000198

Cited by 2 publications

(3 citation statements)

References 75 publications

(97 reference statements)

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“…14,20,26 In cases with recurrence or resistance to immunosuppressive therapy, combination chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP) or CHOP-like chemotherapy and/or stem cell transplants may be employed. 6,26,31 For localized disease, long-term remission has been reported with radiation therapy. 31 Differences in biologic behavior/phenotype have been previously reported between morphologically similar canine and human lymphomas.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, SPTCLs in humans are often indolent and, in many cases, respond well to high doses of systemic corticosteroids as a first line of defense, although hemophagocytic syndrome may develop in some human cases and be associated with poor prognosis. 14,20,26 In cases with recurrence or resistance to immunosuppressive therapy, combination chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP) or CHOP-like chemotherapy and/or stem cell transplants may be employed. 6,26,31 For localized disease, long-term remission has been reported with radiation therapy.…”

Section: Discussionmentioning

confidence: 99%

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Subcutaneous Panniculitis-Like T-cell Lymphoma in Dogs: Morphologic and Immunohistochemical Classification

2018

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Canine nonepitheliotropic cutaneous T-cell lymphomas (NECTCL) are poorly characterized. In humans, a number of distinct subtypes of NECTCL have been recognized, including subcutaneous panniculitis-like T-cell lymphoma (SPTCL). Five dogs with subcutaneous T-cell lymphomas histologically similar to SPTCL in humans are herein described. The mean age was 8.5 years (5.5 to 12 years). No breed or sex predilection was identified in this small cohort. Two dogs presented with an acute onset of multiple skin masses and 3 dogs had solitary masses with subsequent development of multiple smaller masses within 0.5 to 2 months post-diagnosis without treatment. Locations, when specified, included shoulder, neck, and ventral abdomen. Two dogs were euthanized following diagnosis and one dog treated with chemotherapy (CCNU) survived 7 months post-diagnosis. Histologically, all cases were characterized by proliferations of either small to intermediate or large sized, CD3-positive T cells that infiltrated the subcutis in a lace-like pattern and frequently rimmed adipocytes. No epitheliotropism was observed, neoplastic cells were often karyorrhectic, and there were regions of extensive necrosis. Heavy infiltrates of histiocytes with prominent phagocytosis masked the lymphoid neoplastic cell population in some sections. A clonal T-cell receptor gamma gene rearrangement was found in 4 of the 5 cases. While SPTCLs typically have a less aggressive clinical course in humans, their biological behavior in dogs remains to be determined. In summary, SPTCL may represent a distinct entity in dogs and needs to be accurately diagnosed to better determine clinical behavior.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Subcutaneous Panniculitis-Like T-cell Lymphoma in Dogs: Morphologic and Immunohistochemical Classification

2018

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“…Chaudhari et al presented the coupling of CGE to timeof-flight mass spectrometry in hollow nanomechanical resonators [35]. Such a system allows the rough mass determination of proteins in a small portable instrument since it does not require vacuum.…”

Section: Ce-ms Interfacing With Other Ionization Methodsmentioning

confidence: 99%

Recent advances in capillary electrophoresis‐mass spectrometry: Instrumentation, methodology and applications

et al. 2018

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Capillary electrophoresis (CE) offers fast and high‐resolution separation of charged analytes from small injection volumes. Coupled to mass spectrometry (MS), it represents a powerful analytical technique providing (exact) mass information and enables molecular characterization based on fragmentation. Although hyphenation of CE and MS is not straightforward, much emphasis has been placed on enabling efficient ionization and user‐friendly coupling. Though several interfaces are now commercially available, research on more efficient and robust interfacing with nano‐electrospray ionization (ESI), matrix‐assisted laser desorption/ionization (MALDI) and inductively coupled plasma mass spectrometry (ICP) continues with considerable results. At the same time, CE‐MS has been used in many fields, predominantly for the analysis of proteins, peptides and metabolites. This review belongs to a series of regularly published articles, summarizing 248 articles covering the time between June 2016 and May 2018. Latest developments on hyphenation of CE with MS as well as instrumental developments such as two‐dimensional separation systems with MS detection are mentioned. Furthermore, applications of various CE‐modes including capillary zone electrophoresis (CZE), nonaqueous capillary electrophoresis (NACE), capillary gel electrophoresis (CGE) and capillary isoelectric focusing (CIEF) coupled to MS in biological, pharmaceutical and environmental research are summarized.

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Subcutaneous Panniculitis-like T-cell Lymphoma: Review of Therapies

Cited by 2 publications

References 75 publications

Subcutaneous Panniculitis-Like T-cell Lymphoma in Dogs: Morphologic and Immunohistochemical Classification

Subcutaneous Panniculitis-Like T-cell Lymphoma in Dogs: Morphologic and Immunohistochemical Classification

Recent advances in capillary electrophoresis‐mass spectrometry: Instrumentation, methodology and applications

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