Subcutaneous soft tissue tumours at the site of implanted microchips in mice

Tillmann, Thomas; Kamino, Kenji; Dasenbrock, Clemens; Ernst, Heinrich; Köhler, Manfred; Morawietz, Gerd; Campo, Elı́as; Cardesa, Antonio; Tomatis, Lorenzo; Möhr, U.

doi:10.1016/s0940-2993(97)80007-3

Cited by 43 publications

(34 citation statements)

References 6 publications

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“…An advantage of transponder use is that they can be kept within tissues collected from the animals to keep tracking data from the original animal. In contrast to some long-term studies, 20,25,26 no tumours were detected in association with the transponders in 20-week-old C57BL/6J mice in the present study.…”

Section: Postmortem Analysiscontrasting

confidence: 99%

Identification methods in newborn C57BL/6 mice: a developmental and behavioural evaluation

et al. 2010

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The use of group-housed rodents in many fields of biomedical research imposes a need to identify individuals in a cage. Few studies have been designed to assess possible negative effects of identification methods of newborn mice on their development and wellbeing. In the present study, three different identification methods were applied to newborn C57BL/6J mice on postnatal day ( pnd) 5 (toe clipping, toe tattoo ink puncture and subcutaneous implantation of a small transponder). All identification methods used proved to be effective for long-term marking of individual animals. Newborn mice showed the least reaction to toe clipping followed by toe tattoo ink puncture and transponder implantation was the most distressful individual identification procedure in newborn mice. Importantly, clipped toe tissue proved to be enough for genotyping purposes. No overall consistent differences in somatic and neurological reflex development during the postnatal period were shown as a result of the newborn individual identification procedures used. Further, none of the methods interfered significantly with the adult animals' general normal behaviour (e.g. ability to move, grasp, climb) and sensory -motor functions as assessed with a simplified SHIRPA battery of tests, as well as Rotarod and Elevated Plus Maze tests. Postmortem thymus and adrenal gland weights gave no indication of chronic stress as a consequence of the identification method. We conclude that toe clipping might even be advisable in newborn mice at a very young age, when genotyping is needed. Toe tattoo ink puncture is also a good identification method for newborn mice and transponder implantation should only be used in older newborns or applied at weaning.

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Section: Postmortem Analysiscontrasting

confidence: 99%

Identification methods in newborn C57BL/6 mice: a developmental and behavioural evaluation

et al. 2010

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“…Indeed, chronic mechanical irritation is known to promote tumorigenesis in many tissues, as shown by the correlations between gallstones and gall bladder carcinoma (Vitetta et al, 2000), urinary calculus and urinary bladder carcinoma (Harzmann et al, 1983), ill-fitting dentures and oral squamous cell carcinoma (Young et al, 1986;Lockhart et al, 1998), and subcutaneously implanted microchips and fibrosarcoma (Tillmann et al, 1997). In addition, it has been shown in vivo that mechanical irritation of the epithelium can lead to an increased mutation rate (Takahashi et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

Mechanical factors activateß‐catenin‐dependent oncogene expression in APC^1638N/+mouse colon

et al. 2008

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“…However, sarcomas have been induced by implanted microchips in Fischer 344 rats and various conventional mouse strains. Reported incidences in implanted Fischer rats is about 1% and mice they range between about 2 and 4% in B6C3F1 mice, 1.2% in CBA/J female mice, 0.5% in CBA/J male mice whereas CD-1 mice are more resistant( 110 Tillmann et al 1997; 33 Elcock et al 2001; 67 Le Calvez et al 2006).…”

Section: Morphologymentioning

confidence: 99%

Proliferative and Non-Proliferative Lesions of the Rat and Mouse Soft Tissue, Skeletal Muscle and Mesothelium

et al. 2013

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The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP), and North America (STP) to develop an internationally accepted nomenclature for proliferative and nonproliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature for classifying lesions observed in the soft tissues including skeletal muscle as well as the mesothelium of rats and mice. The standardized nomenclature of lesions presented in this document is also available electronically on the Internet (http://www.goreni.org/). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous developmental and aging lesions as well as those induced by exposure to test materials. A widely accepted and utilized international harmonization of nomenclature for lesions in soft tissues, skeletal muscle and mesothelium in laboratory animals will decrease confusion among regulatory and scientific research organizations in different countries and provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists. (DOI: 10.1293/tox.26.1S; J Toxicol Pathol 2013; 26: 1S–26S)

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Subcutaneous soft tissue tumours at the site of implanted microchips in mice

Cited by 43 publications

References 6 publications

Identification methods in newborn C57BL/6 mice: a developmental and behavioural evaluation

Identification methods in newborn C57BL/6 mice: a developmental and behavioural evaluation

Mechanical factors activateß‐catenin‐dependent oncogene expression in APC^1638N/+mouse colon

Proliferative and Non-Proliferative Lesions of the Rat and Mouse Soft Tissue, Skeletal Muscle and Mesothelium

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Subcutaneous soft tissue tumours at the site of implanted microchips in mice

Cited by 43 publications

References 6 publications

Identification methods in newborn C57BL/6 mice: a developmental and behavioural evaluation

Identification methods in newborn C57BL/6 mice: a developmental and behavioural evaluation

Mechanical factors activateß‐catenin‐dependent oncogene expression in APC1638N/+mouse colon

Proliferative and Non-Proliferative Lesions of the Rat and Mouse Soft Tissue, Skeletal Muscle and Mesothelium

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Mechanical factors activateß‐catenin‐dependent oncogene expression in APC^1638N/+mouse colon