Subcutaneous Sumatriptan Relieved Migraine‐Like Headache in Two Adolescents With Aseptic Meningitis

Abstract

Sumatriptan was developed as an agent for the treatment of acute migraine. However, sumatriptan may alleviate not only migraine headache, but also headache of subarachnoid hemorrhage and meningitis. We report 2 patients whose migraine-like headache on presentation was relieved by subcutaneous sumatriptan. Later, both patients were diagnosed with aseptic meningitis.

Headache in Drug-Induced Aseptic Meningitis

“…In some cases, the headache is described to be global, progressive and intense [6], other patients have pressure-like pain [7], sometimes the headache is constant and frontally localized [8] and others have a recurrent headache [9]. Single case reports show that headache in aseptic meningitis might be migraine-like [10][11][12] and even sufficiently treated with subcutaneous application of sumatriptan [10].…”

Sumatriptan improves postoperative quality of recovery and reduces postcraniotomy headache after cranial nerve decompression

“…[11][12][13] The rapid onset of action of sumatriptan could potentially be useful for immediate postoperative management of headache, but it has not been tested for treatment of postcraniotomy headache. [14][15][16][17][18] We hypothesized that sumatriptan is helpful in the management of headache and its associated symptoms after MVD, and that this is associated with improvement in the quality of recovery. We conducted a randomized controlled study to investigate the effects of s.c. administration of sumatriptan on postoperative headache and quality of recovery after MVD surgery.…”

Headache Secondary to Mass Responsive to Sumatriptan: A Brief Report From Primary Care

“…We present a case of secondary headache due to a non‐pituitary cerebral mass, responsive to sumatriptan. Other reported secondary headaches responsive to a 5‐HT1B/1D receptor agonist include benign lymphocytic meningitis, aseptic meningitis, and subarachnoid hemorrhage, pituitary macroadenoma, or other pituitary mass lesion . We believe that this case represents a previously unreported observation.…”