Purpose. Study on the processes contributing to the formation of pyrite-polymetallic mineralization in the Rudny Altai, development of recommendations for directions for further research. Methodology. Analysis of literature and fund materials, field studies within known ore fields and deposits, sampling and laboratory studies: spectral analysis, studies on the chemical composition of host rocks (ISP-MS Agilent 7500cx), study on the mineral composition of the main types of mineralization (JSM 6390LV)). Findings. A model of pyrite-polymetallic mineralization genetically related to the Devonian basalt-andesite-rhyolite Early Hercynian riftogenic volcanism (D1e-D3fr) was developed. Originality. The spatial confinement of a number of industrial deposits, areas of sulfide mineralization and near-ore-hydrothermally altered rocks to the areas of pinching out of inter- and sub-stratal subvolcanic porphyries of the Middle Upper Devonian and overlying porphyrites, creating a kind of ore-magmatic systems (OMS), has been established. Practical value. A new stage of deep geological study on the territory of the Rudny Altai and promising ore-bearing structures with the introduction of modern methods of deep geological and mineragenic mapping is recommended.