Subendometrial arterial spectral doppler assessment during IVF cycles and its correlation with treatment outcome

Adenomyosis does not affect implantation, but is associated with miscarriage in patients undergoing oocyte donation

“…For this reason, the mechanisms leading to adenomyosis-associated infertility have been explained in similar physiopathological terms to those of endometriosis (20)(21)(22)(23)(24). More recently, it has been suggested that an inadequate blood supply to the endometrium interferes with implantation (25,26), but functional studies addressing the effects of adenomyosis on endometrial receptivity are scarce.…”

Impact of obesity on endometrial blood flow in women without polycystic ovarian syndrome during intracytoplasmic sperm injection

“…Higher spiral arterial PI appears to negatively affect endometrial blood vessel function. Gorokhovsky et al [17] assessed 39 women undergoing IVF and found significantly reduced spiral artery PI values in pregnancy cycles compared to nonpregnancy cycles at the beginning of treatment. Spiral artery RI and S/D did not differ between these groups along the treatment course.…”

“…In these patients, the spiral arterial PI was significantly higher in the obese group than in the normal weight group, but the RI and S/D measurements were comparable in the 4 BMI subgroups. The significant difference in PI, but not in RI and S/D, could be related to the PI calculation method, which takes the entire spectral Doppler waveform into account and not just the maximal and minimal frequency shifts, as in the calculation of RI and S/D [17]. Sivitz et al [37] reported that microvascular vasodilator function is impaired in obese women, and women appeared more sensitive to the deleterious effect of obesity on endothelium-mediated resistance vessel function.…”

“…Sufficient blood supply to the endometrium and subendometrium indicates good endometrial receptivity, and an absence of both is representative of an unfavorable uterine environment. Furthermore, lower spiral artery pulsatility index (PI) at the beginning of treatment or on the oocyte pick-up (OPU) day was found in pregnancy cycles compared to nonpregnancy cycles, whereas the spiral artery resistance index (RI) and systolic/diastolic ratio (S/D) did not differ between the groups along the course of treatment [17,18]. …”