Subjective cognitive decline in cognitively normal elders from the community or from a memory clinic: Differential affective and imaging correlates

Abstract

These results further validate the concept of SCD in both community- and clinic-based groups. Yet, recruitment methods influence associated biomarkers and affective symptomatology, highlighting the heterogeneous nature of SCD depending on study characteristics.

Sleep changes without medial temporal lobe or brain cortical changes in community‐dwelling individuals with subjective cognitive decline

“…However, in line with other SCD studies [2,27], we found a trend for higher, subclinical depressive symptoms in our SCD participants. Therefore, another possible explanation of our results could be that subclinical depression might have caused SCD complaints.…”

“…In fact, many studies suggest that SCD might be the expression of AD-related brain changes that have already occurred in the MTL [20–27] or in other brain cortical regions [23,27]. However, although some MRI studies found MTL and/or cortical differences between SCD and controls [20–27], other studies failed to find these differences [20,27,28].…”

“…In fact, many studies suggest that SCD might be the expression of AD-related brain changes that have already occurred in the MTL [20–27] or in other brain cortical regions [23,27]. However, although some MRI studies found MTL and/or cortical differences between SCD and controls [20–27], other studies failed to find these differences [20,27,28]. In particular, in one study, SCD was significantly associated with both cross-sectional and longitudinal hippocampal volume changes [20], whereas another study showed that hippocampal volumes in SCD participants were similar to MCI, but not statistically different from control participants [28].…”

“…In particular, in one study, SCD was significantly associated with both cross-sectional and longitudinal hippocampal volume changes [20], whereas another study showed that hippocampal volumes in SCD participants were similar to MCI, but not statistically different from control participants [28]. Another very interesting study conducted by Perrotin et al (in press, [27]) showed that although community-dwelling SCD did not show any brain regional volume change compared with controls, SCD recruited from the clinic showed reduced volume in several brain regions, including the left hippocampus. These inconsistent MRI findings are likely related to differences in the populations sampled (e.g., recruitment from the community vs. clinic), the criteria used to define SCD, and the approaches used for the MRI analysis across these studies.…”

“…Although MCI and AD patients show reliably reduced MTL thickness and volume [17–19], these findings are not as consistent in SCD, with some studies showing group differences between SCD and controls [20–27] and other failing to detect differences in MTL structures [20,27,28]. …”