Subjects with seasonal allergic rhinitis and nonrhinitic subjects react differentially to nasal provocation with chlorine gas☆☆☆★★★

Shusterman, Dennis; Murphy, Mary Alice; Balmes, John R.

doi:10.1016/s0091-6749(98)70302-1

Cited by 75 publications

(51 citation statements)

References 19 publications

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“…Nasal symptoms related to physical and chemical factors. Physical and chemical factors can induce nasal symptoms which may mimic rhinitis in subjects with sensitive mucous membranes and even in normal subjects if the concentration of chemical triggers is high enough (173,174). Sudden changes in temperature can induce nasal symptoms in patients with allergic rhinitis (175).…”

Section: Hormonal Rhinitismentioning

confidence: 99%

See 1 more Smart Citation

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Bousquet¹,

Khaltaev²,

Cruz³

et al. 2008

Allergy

3,861

1,761

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Section: Hormonal Rhinitismentioning

confidence: 99%

“…However, more than 250 different chemical entities have been identified. Some compounds like chlorine can induce irritant rhinitis in 30-50% of exposed workers (173,174).…”

Section: Other Mitesmentioning

confidence: 99%

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Bousquet¹,

Khaltaev²,

Cruz³

et al. 2008

Allergy

3,861

1,761

View full text Add to dashboard Cite

“…For example, chamber data identify higher levels of symptoms in atopic individuals exposed to the same levels of complex mixtures of VOCs (16,47,48). Atopic individuals respond with a larger decrease in nasal resistance to a defined irritant challenge than do nonatopics (49). Higher-than-average symptoms after application of dilute lactic acid to the skin are associated with more dermal complaints in the office (50).…”

Section: Symptoms Without Explained Physiology But With Objective Marmentioning

confidence: 99%

Indoor environmental exposures and symptoms.

Hodgson

2002

Environ Health Perspect

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The label "sick building syndrome" is often used to imply the absence of a physiologic basis for symptoms in the built environment. Although building-related illness is widely recognized but considered rare, several well-studied mechanisms may be responsible for many symptoms in buildings. These mechanisms do not explain why some individuals perceive disability. Until researchers distinguish physiologic mechanisms from other aspects of disease and study them systematically, poorly defined symptoms will remain poorly understood. The disability associated with such symptoms and syndromes, not the physiology, is the primary interest and generates controversy.

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“…In swimmers chlorine inhalation (an irritant) induces nasal congestion in a more pronounced way in subjects with allergic rhinitis than in nonrhinitic. Some authors explained this fact by nasal mucosa damage mediated by chlorinated products, which could facilitate the penetration of aeroallergens increasing the risk of allergic manifestation (Shusterman, Murphy et al 1998;Shusterman, Balmes et al 2003;Shusterman, Murphy et al 2003). This hypothesis was not supported by a more recent study showing that swimmers had worse rhinitis symptoms, but independently of their atopic status (Alves, Martins et al 2010).…”

Section: Nasal Physiology and Pathophysiologymentioning

confidence: 99%