Subjects with TNF-A-857TT and -1031TT genotypes showed the highest Helicobacter pylori seropositive rate compared with those with other genotypes

Associations of TNF-A-1031TT and -857TT genotypes with Helicobacter pylori seropositivity and gastric atrophy among Japanese Brazilians

“…In fact, reported studies were supportive for the associations of H. pylori Age was adjusted by three dummy variables for ages 40-49, 50-59, and 60-69 years seropositivity with TNF-A -1031TT and/or -857TT genotypes. 7,8 There are a few reports on the function of TNF-A T-1031C and C-857T polymorphisms. In an in vitro study, the TNF-α level and the transcriptional promoter activity produced by concanavalin A-activated peripheral blood mononuclear cells were higher for the -857T or -1031C alleles than for the -857C or -1031T alleles, respectively (n = 9).…”

“…Genotyping was conducted by polymerase chain reaction with confronting two-pair primers (PCR-CTPP), 18 using 25 µl of PCR mixture, as described in our previous study. 7 Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by an unconditional logistic model. Age was adjusted using dummy variables for 10-year age groups.…”

“…8 Our previous study showed that those harboring -1031TT and -857TT had the highest H. pylori seropositive rate. 7 The present study examined whether the associations of TNF-A T-1031C and C-857T genotypes with H. pylori seropositivity were reproduced among Japanese Brazilians, who maintain Japanese lifestyles, and have a high gastric cancer mortality rate, similar to that of Japanese in Japan. 14 In addition, the association with gastric atrophy was studied among the seropositives.…”

“…6 The -1031C allele is also linked with the -857C allele, and no haplotypes for -1031C linked with -857C were found in our previous study in 1361 Japanese. 7 Significant associations of the TNF-A -308A allele with H. pylori infection have been reported in Italy, 8 and such associations with CagA-positive H. pylori infection have been reported in Korea. 9 A small study in Korea showed that the -308A allele was significantly more frequent in patients infected with CagA+ H. pylori (9 out of 46) than in healthy controls with unknown H. pylori infection status (7 out of 113).…”

Significant association between PTPN11 polymorphism and gastric atrophy among Japanese Brazilians

“…Recent studies have suggested that combinations of host genetic traits and bacterial virulence determine the severity of the gastric damage and the eventual clinical outcome of H. pylori infection [7][8][9]. There is no doubt that the frequency of H. pylori exposure is the deterministic factor for the infection, but genetic traits of the host could also affect the susceptibility to H. pylori infection and its persistence [10,11].…”