Sublimation properties of x,y-dihydroxybenzoic acid isomers as model matrix assisted laser desorption ionisation (MALDI) matrices

Price, Duncan M.; Bashir, Sajid; Derrick, Peter R.

doi:10.1016/s0040-6031(98)00606-6

Cited by 48 publications

(59 citation statements)

References 19 publications

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“…Some of the matrices evaporated/sublimed too rapidly in vacuum, a common observation in vacuum MALDI [116,117]. For this and related reasons, the utility of binary matrices were explored.…”

Section: Matrices Tested Using Laserspray Ionizationmentioning

confidence: 99%

Matrix Assisted Ionization: New Aromatic and Nonaromatic Matrix Compounds Producing Multiply Charged Lipid, Peptide, and Protein Ions in the Positive and Negative Mode Observed Directly from Surfaces

Inutan

Wang

et al. 2012

J. Am. Soc. Mass Spectrom.

213

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Matrix assisted inlet ionization (MAII) is a method in which a matrix:analyte mixture produces mass spectra nearly identical to electrospray ionization without the application of a voltage or the use of a laser as is required in laserspray ionization (LSI), a subset of MAII. In MAII, the sample is introduced by, for example, tapping particles of dried matrix:analyte into the inlet of the mass spectrometer and, therefore, permits the study of conditions pertinent to the formation of multiply charged ions without the need of absorption at a laser wavelength. Crucial for the production of highly charged ions are desolvation conditions to remove matrix molecules from charged matrix: analyte clusters. Important factors affecting desolvation include heat, vacuum, collisions with gases and surfaces, and even radio frequency fields. Other parameters affecting multiply charged ion production is sample preparation, including pH and solvent composition. Here, findings from over 100 compounds found to produce multiply charged analyte ions using MAII with the inlet tube set at 450°C are presented. Of the compounds tested, many have -OH or -NH 2 functionality, but several have neither (e.g., anthracene), nor aromaticity or conjugation. Binary matrices are shown to be applicable for LSI and solvent-free sample preparation can be applied to solubility restricted compounds, and matrix compounds too volatile to allow drying from common solvents. Our findings suggest that the physical properties of the matrix such as its morphology after evaporation of the solvent, its propensity to evaporate/sublime, and its acidity are more important than its structure and functional groups.

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“…Some of the matrices evaporated/sublimed too rapidly in vacuum, a common observation in vacuum MALDI [116,117]. For this and related reasons, the utility of binary matrices were explored.…”

Section: Matrices Tested Using Laserspray Ionizationmentioning

confidence: 99%

Matrix Assisted Ionization: New Aromatic and Nonaromatic Matrix Compounds Producing Multiply Charged Lipid, Peptide, and Protein Ions in the Positive and Negative Mode Observed Directly from Surfaces

Inutan

Wang

et al. 2012

J. Am. Soc. Mass Spectrom.

213

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“…In addition, it can be used to study its phase transitions such as sublimation and the related properties such as vaporpressure [27][28][29]. TGA provides a fast and reliable method to study a number of compounds that are thermally stable up to their melting point at ambient pressure [27,29].…”

Section: Sublimation Pressurementioning

confidence: 99%

“…TGA provides a fast and reliable method to study a number of compounds that are thermally stable up to their melting point at ambient pressure [27,29]. Using this method, the evaporation rate of a compound determined under isothermal conditions is directly related to its vapor pressure [27][28][29][30][31].…”

Section: Sublimation Pressurementioning

confidence: 99%

Catechin sublimation pressure and solubility in supercritical carbon dioxide

Soetaredjo¹,

Ismadji²,

Yuliana³

et al. 2013

Fluid Phase Equilibria

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a b s t r a c tSolubility of (+)-catechin in SC-CO 2 was measured at several temperatures (313.15, 323.15, 333.15 and 343.15 K) and pressure in the range of 12-26 MPa using ethanol as the co-solvent (5 mol.%). The experimental data were used for the correlation of density dependent solute solubility parameters. The equations of Chrastil, del Valle and Aguilera, Adachi and Lu, González, and Méndez-Santiago and Tejawere fitted very well for the solubility of (+)-catechin. The rate of mass loss of (+)-catechin showed that its sublimation pressure is very low, an indication of the stability of the compound. Thermogravimetric analysis was used to determine the sublimation pressure.

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“…Partial incorporation was found with 2,4-DHB but the authors concluded that, although incorporation aided the MALDI process, it was not essential. The enthalpies of sublimation of six isomers of DHB have been measured but no correlation was found with their ability to act as MALDI matrices (Price, Bashir, & Derrick, 1999). Matrix adducts with DHB have been observed in at least two studies; thus, [M þ DHB-H] À ions have been detected from oligomers of underivatized amylose, cellulose, and certain cyclodextrins that contained four or more glucose residues (Mele & Malpezzi, 1999).…”

Section: A Common Matricesmentioning

confidence: 99%

Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update covering the period 1999–2000

Harvey

2006

Mass Spectrometry Reviews

125

112

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This review describes the use of matrix-assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of carbohydrates and glycoconjugates and continues coverage of the field from the previous review published in 1999 (D. J. Harvey, Matrix-assisted laser desorption/ionization mass spectrometry of carbohydrates, 1999, Mass Spectrom Rev, 18:349-451) for the period 1999-2000. As MALDI mass spectrometry is acquiring the status of a mature technique in this field, there has been a greater emphasis on applications rather than to method development as opposed to the previous review. The present review covers applications to plant-derived carbohydrates, N- and O-linked glycans from glycoproteins, glycated proteins, mucins, glycosaminoglycans, bacterial glycolipids, glycosphingolipids, glycoglycerolipids and related compounds, and glycosides. Applications of MALDI mass spectrometry to the study of enzymes acting on carbohydrates (glycosyltransferases and glycosidases) and to the synthesis of carbohydrates, are also covered.

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Sublimation properties of x,y-dihydroxybenzoic acid isomers as model matrix assisted laser desorption ionisation (MALDI) matrices

Cited by 48 publications

References 19 publications

Matrix Assisted Ionization: New Aromatic and Nonaromatic Matrix Compounds Producing Multiply Charged Lipid, Peptide, and Protein Ions in the Positive and Negative Mode Observed Directly from Surfaces

Matrix Assisted Ionization: New Aromatic and Nonaromatic Matrix Compounds Producing Multiply Charged Lipid, Peptide, and Protein Ions in the Positive and Negative Mode Observed Directly from Surfaces

Catechin sublimation pressure and solubility in supercritical carbon dioxide

Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update covering the period 1999–2000

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