Sublingual delivery of chondroitin sulfate conjugated tapentadol loaded nanovesicles for the treatment of osteoarthritis

Chondroitin sulfate-based composites: a tour d’horizon of their biomedical applications

“…As conjugated NVs had more uptake efficacy by the joints, so the C-MB-NVs displayed maximum recovery in the knee joints, with 11.7% in 1 h. This improved and targeted uptake of the nanovesicles in the knee joints can be demonstrated by the CD44 receptor, which remains overexpressed at the site that has been affected, thus corroborating more targeted and sustained release. 396 In order to develop an effective nanoplatform for targeted tumor therapy, Lee H. et al, fabricated CS-hybridized zein NPs (zein/CS NPs) for the delivery of docetaxel. The prepared NPs released docetaxel in a sustained way (B72 h), and followed first-order kinetics.…”

“…As conjugated NVs had more uptake efficacy by the joints, so the C-MB-NVs displayed maximum recovery in the knee joints, with 11.7% in 1 h. This improved and targeted uptake of the nanovesicles in the knee joints can be demonstrated by the CD44 receptor, which remains overexpressed at the site that has been affected, thus corroborating more targeted and sustained release. 396…”

Promising Antifungal Potential of Engineered Non-ionic Surfactant-Based Vesicles: In Vitro and In Vivo Studies

“…S1 (a)). The obtained dispersion was sonicated (bath sonicator, Elmasonic S40, Elma, Singen, Germany) for 1 min to yield unilamellar vesicles (20,36).…”

“…These surfactant-based vesicular systems provide a longer duration of action of the drug in ocular tissue and minimize the systemic drainage. The niosomes of varying compositions employed for topical ophthalmic drug delivery have enhanced the activity with reduced side effects (18)(19)(20). Niosomal formulation (less than 10 μm) has been depicted to be optimum for ophthalmic delivery, for carrying a remarkable quantity of drug moiety, and also shows resistance for "lacrimal flushing effect" (19,(21)(22)(23)(24).…”