Sublingual Erythrol Tetranitrate in the Treatment of Angina Pectoris. Effect of Varying the Dose and Rate of Administration

Ge, Altman; Je, Riseman; Koretsky, Sidney

doi:10.1097/00000441-196007000-00008

Cited by 11 publications

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“…The morphology of the tissue and its constant exposure to inflammatory agents and mechanical stress suggest that the oral sulcular epithelium is a weak barrier to antigenic substances, as attested to by numerous in vivo and in vitro permeability studies. Studies on permeation of substances through mucosal tissues have included measurements of permeability to [3H] -H2 0 (Kaaber, 1 973;Adams, 1974), drugs (Altman et al, 1960), topical application of antigen (Rizzo, 1970;McDougall, 1972), labeled human albumin (Tolo, 1971), horseradish peroxidase (Squier, 1973), endotoxin (Schwartz et al, 1973;Alfano et al,, 1975), inulin (Alfano et al, 1977), and dextran (Tolo and Johnsen, 1975). The initiation of periodontal disease appears to be associated with the breakdown of the integrity of epithelial basement membrane (Stern, 1965).…”

Section: Introductionmentioning

confidence: 99%

Effect of Hydrogen Sulfide and Methyl Mercaptan on the Permeability of Oral Mucosa

1984

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Hydrogen sulfide (H2S) and methyl mercaptan (CH3SH) are the volatile sulfur compounds (VSC) that were investigated for a possible role in the etiology of periodontal disease. The results show that the permeability of porcine non-keratinized sublingual mucosa is increased by up to 75% or 103% following exposure to H2S and CH3SH, respectively. The effect may be attributed to VSC reaction with tissue components resulting in alteration in the integrity of the tissue barrier. The increase in permeability of the mucosa to [35S]-Na2SO4 was dependent on both the time of exposure and concentration of VSC in the head-space. The [35S]-H2S was retained by the mucosal tissue and was able to penetrate the intact layers consisting of non-keratinized epithelium, basal membrane, and connective tissue. Treatment of the mucosa with 0.22% ZnCl2, either prior to or after exposure to CH3SH, nullified the effect of CH3SH and restored the permeability to a state similar to that observed in control 95% air/5% CO2 systems.

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