Sublingual immunotherapy in patients with house dust mite allergic rhinitis: prospective study of clinical outcomes over a two-year period

Soh, Jian Yi; Thalayasingam, Meera; Ong, Shi Ting; Chao, Siew Shuen

doi:10.1017/s0022215116000025

Cited by 13 publications

(12 citation statements)

References 32 publications

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“…The authors conclude that subcutaneous immunotherapy is effective for house dust mite induced allergy, even 10 years after treatment. This study follows previous research which demonstrated that sublingual immunotherapy with house dust mite extracts is also efficacious for patients with house dust mite allergic rhinitis 7 …”

supporting

confidence: 88%

“…This study follows previous research which demonstrated that sublingual immunotherapy with house dust mite extracts is also efficacious for patients with house dust mite allergic rhinitis. 7 Finally, an article by Luu et al 8 in this month's issue continues the theme of surgical simulation, 9,10 and evaluates a low-fidelity ear surgery simulator for developing otological microsurgical skills in lowresource settings. Simulation has become increasingly popular as a method of training surgeons in lowresource settings, with no risk to patient safety.…”

mentioning

confidence: 99%

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All change…transcanal endoscopic ear surgery and house dust mite immunotherapy for allergic rhinitis

Fishman¹,

Youngs²,

Fisher³

et al. 2017

J. Laryngol. Otol.

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All change…transcanal endoscopic ear surgery and house dust mite immunotherapy for allergic rhinitis Endoscopic ear surgery is increasingly becoming commonplace in otological practice. 1 Advantages include the panoramic views obtained with the use of the otoendoscope outside of the microscope's line of sight and higher magnification. One of the drawbacks is only having a single hand available for dissection. In addition, endoscopic ear surgery limits the ability to use standard drills because of the risk of damage to the endoscope and the limited workspace in the external auditory canal.In this month's issue of The Journal of Laryngology & Otology, Gardner et al. describe the feasibility and safety of using an ultrasonic bone aspirator in transcanal endoscopic ear surgery. 2 Although the study was only performed on cadaveric temporal bones, it is a landmark study in that it illustrates the potential for powered instrumentation in endoscopic ear surgery, much like how functional endoscopic sinus surgery started out in its early days. The authors demonstrate the ease of bone removal with the ultrasonic aspirator (as demonstrated by the supplementary video material, available online at The Journal website 3 ), with no additional complications and a significant reduction in the time taken to perform an atticoantrostomy, compared with standard bone curettage.The efficacy, tolerability and safety of subcutaneous and sublingual immunotherapy for allergic rhinitis is hotly debated, and is the subject of the recently published European Academy of Allergy and Clinical Immunology guidelines on allergen immunotherapy. 4,5 An article by Sahin et al. in this month's issue investigated the long-term effects of subcutaneous immunotherapy for house dust mite induced allergic rhinitis, based on a 10-year follow up. 6 The authors conclude that subcutaneous immunotherapy is effective for house dust mite induced allergy, even 10 years after treatment. This study follows previous research which demonstrated that sublingual immunotherapy with house dust mite extracts is also efficacious for patients with house dust mite allergic rhinitis. 7 Finally, an article by Luu et al. 8 in this month's issue continues the theme of surgical simulation, 9,10 and evaluates a low-fidelity ear surgery simulator for developing otological microsurgical skills in lowresource settings. Simulation has become increasingly popular as a method of training surgeons in lowresource settings, with no risk to patient safety. Such a tool may be highly valuable in helping to train future surgeons to manage middle-ear disease. JONATHAN FISHMAN ROBIN YOUNGS EDWARD FISHER MUSHEER HUSSAIN Senior Editors

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supporting

confidence: 88%

mentioning

confidence: 99%

All change…transcanal endoscopic ear surgery and house dust mite immunotherapy for allergic rhinitis

Fishman¹,

Youngs²,

Fisher³

et al. 2017

J. Laryngol. Otol.

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“…Studies comparing the efficacy of AIT between pediatric and adult patients are limited. A prospective observational study by Soh and colleagues17 indicated that although improvements in medical scores were greater in children than in adults after SLIT, the differences were not significant. In contrast, our study demonstrated that improvements in TNSS and TCS following HDM-SCIT were significantly greater in pediatric AR patients than in adult AR patients.…”

Section: Discussionmentioning

confidence: 98%

“…In recent years, there has been accumulating evidence for the efficacy and safety of AIT for AR, with several studies demonstrating both short-term efficacy8910 and long-term efficacy, using mainly SLIT 11121314. However, comparatively few studies have reported on the efficacy of AIT in Chinese AR patients, with the available data documenting the efficacy of SLIT in pediatric and adult AR patients 151617. Thus, this study aimed to compare the long-term efficacy and safety of SCIT in children and adults with AR.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Long-term Efficacy of Subcutaneous Immunotherapy in Pediatric and Adult Patients With Allergic Rhinitis

Huang

Wang

Cao

et al. 2019

Allergy Asthma Immunol Res

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PurposeData comparing the long-term efficacy and safety of subcutaneous immunotherapy (SCIT) using house dust mite (HDM) in children and adults with allergic rhinitis (AR) are limited. This study aimed to compare the long-term effects of HDM-SCIT in a cohort of Chinese pediatric and adult patients with AR.MethodsA total of 124 pediatric and adult AR patients received HDM-SCIT for 3 years, with 118 patients being followed-up for 2 years. Prior to treatment (baseline), at the end of the 3-year treatment periods (third year) and 2 years after the discontinuation of treatment (fifth year), all patients were evaluated for total nasal symptom scores (TNSS), daily medication score (DMS), total combined score (TCS; symptoms [nasal + ocular] + DMS) and quality of life (QoL). Safety was assessed according to adverse events reported.ResultsAfter 3-year treatment, HDM-SCIT significantly improved symptoms and QoL scores at the end of the third and fifth years in both groups. Better improvements were observed in the third and fifth years based on baseline, in children compared to adults (TNSSΔ3: 6.66 vs. 5.41, P = 0.011; TCSΔ3: 4.30 vs. 3.83, P = 0.027 and TNSSΔ5: 6.16 vs. 4.86, P = 0.037; TCSΔ5: 4.11 vs. 3.62, P = 0.044).Shorter duration of AR history before SCIT (<10 vs. ≥10 years) resulted in better improvements at the end of the third and fifth years (TCSΔ3: 4.12 vs. 3.13, P = 0.036; TCSΔ5: 3.90 vs. 3.09, P = 0.033). HDM-SCIT was safe and comparable in both children and adults with AR.ConclusionsChildren with AR may achieve better long-term efficacy of HDM-SCIT than adults with AR.

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“…SLIT to HDM has also been shown to be effective in HDM AR/C by improving nasal and ocular symptoms, which exceeded World Allergy Organization-established clinical efficacy criteria (≥20% improvement versus placebo) by 8 weeks [46]. In a Singapore study, SLIT to all 3 HDM species was found to be effective following pooled analysis in both children and adults [47]. SQ ALK-Abello HDM SLIT tablet has been approved in 11 European countries and Japan for patients with HDM-induced respiratory allergic disease.…”

Section: House Dust Mite Allergen Immunotherapymentioning

confidence: 99%

Allergic conjunctivitis in Asia

Thong

2017

Asia Pacific Allergy

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Allergic conjunctivitis (AC), which may be acute or chronic, is associated with rhinitis in 30%–70% of affected individuals, hence the term allergic rhinoconjunctivitis (AR/C). Seasonal and perennial AC is generally milder than the more chronic and persistent atopic and vernal keratoconjunctivitis. Natural allergens like house dust mites (HDM), temperate and subtropical grass and tree pollen are important triggers that drive allergic inflammation in AC in the Asia-Pacific region. Climate change, environmental tobacco smoke, pollutants derived from fuel combustion, Asian dust storms originating from central/north Asia and phthalates may also exacerbate AR/C. The Allergies in Asia Pacific study and International Study of Asthma and Allergies in Childhood provide epidemiological data on regional differences in AR/C within the region. AC significantly impacts the quality of life of both children and adults, and these can be measured by validated quality of life questionnaires on AR/C. Management guidelines for AC involve a stepped approach depending on the severity of disease, similar to that for allergic rhinitis and asthma. Topical calcineurin inhibitors are effective in certain types of persistent AC, and sublingual immunotherapy is emerging as an effective treatment option in AR/C to grass pollen and HDM. Translational research predominantly from Japan and Korea involving animal models are important for the potential development of targeted pharmacotherapies for AC.

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Sublingual immunotherapy in patients with house dust mite allergic rhinitis: prospective study of clinical outcomes over a two-year period

Abstract: Sublingual immunotherapy with house dust mite extracts, including B tropicalis, is efficacious as a treatment for patients with house dust mite allergic rhinitis.

Cited by 13 publications

References 32 publications

All change…transcanal endoscopic ear surgery and house dust mite immunotherapy for allergic rhinitis

All change…transcanal endoscopic ear surgery and house dust mite immunotherapy for allergic rhinitis

Comparison of Long-term Efficacy of Subcutaneous Immunotherapy in Pediatric and Adult Patients With Allergic Rhinitis

Allergic conjunctivitis in Asia

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