Submicrometer Hollow Bioglass Cones Deposited by Radio Frequency Magnetron Sputtering: Formation Mechanism, Properties, and Prospective Biomedical Applications

Popa, Ana Maria; Stan, George E.; Beșleagă, Cristina; Ion, L.; Maraloiu, Valentin-Adrian; Tulyaganov, Dilshat U.; Ferreira, J.M.F.

doi:10.1021/acsami.6b00606

Cited by 26 publications

(21 citation statements)

References 70 publications

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“…Prior to deposition, the substrates were etched for 10 min in argon (Ar) plasma (0.3 Pa) produced by a wolfram plasmatron by applying a 0.4 kV DC bias voltage and a power of ~200 W, in order to remove the potential remnant impurities. Earlier studies have evidenced the positive role of this procedure on the adherence of the sputtered films [ 54 , 55 , 56 ]. The process was optimized in the past; longer etching times or higher plasma power value leading to morphological irregularities on substrate surface, which are unfavorable to an optimal growth of a film with minimized internal tensions.…”

Section: Methodsmentioning

confidence: 99%

Mechanical, Corrosion and Biological Properties of Room-Temperature Sputtered Aluminum Nitride Films with Dissimilar Nanostructure

et al. 2017

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Aluminum Nitride (AlN) has been long time being regarded as highly interesting material for developing sensing applications (including biosensors and implantable sensors). AlN, due to its appealing electronic properties, is envisaged lately to serve as a multi-functional biosensing platform. Although generally exploited for its intrinsic piezoelectricity, its surface morphology and mechanical performance (elastic modulus, hardness, wear, scratch and tensile resistance to delamination, adherence to the substrate), corrosion resistance and cytocompatibility are also essential features for high performance sustainable biosensor devices. However, information about AlN suitability for such applications is rather scarce or at best scattered and incomplete. Here, we aim to deliver a comprehensive evaluation of the morpho-structural, compositional, mechanical, electrochemical and biological properties of reactive radio-frequency magnetron sputtered AlN nanostructured thin films with various degrees of c-axis texturing, deposited at a low temperature (~50 °C) on Si (100) substrates. The inter-conditionality elicited between the base pressure level attained in the reactor chamber and crystalline quality of AlN films is highlighted. The potential suitability of nanostructured AlN (in form of thin films) for the realization of various type of sensors (with emphasis on bio-sensors) is thoroughly probed, thus unveiling its advantages and limitations, as well as suggesting paths to safely exploit the remarkable prospects of this type of materials.

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Section: Methodsmentioning

confidence: 99%

Mechanical, Corrosion and Biological Properties of Room-Temperature Sputtered Aluminum Nitride Films with Dissimilar Nanostructure

et al. 2017

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“…FTIR spectra (Figure 4) indicated an intensity enhancement of ), determined by the Q Si 4 silicate units. SEM analysis of BG-coating surfaces ( Figure 5) revealed morphologies that were typical of amorphous structures deposited by radio-frequency magnetron sputtering, [51][52][53] characterization of in vitro-tested BG films…”

Section: Characterization Of Starting Bg Powder and As-sputtered Bg Cmentioning

confidence: 99%

Bioglass implant-coating interactions in synthetic physiological fluids with varying degrees of biomimicry

Popa¹,

Stan²,

Husanu³

et al. 2017

IJN

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Synthetic physiological fluids are currently used as a first in vitro bioactivity assessment for bone grafts. Our understanding about the interactions taking place at the fluid–implant interface has evolved remarkably during the last decade, and does not comply with the traditional International Organization for Standardization/final draft International Standard 23317 protocol in purely inorganic simulated body fluid. The advances in our knowledge point to the need of a true paradigm shift toward testing physiological fluids with enhanced biomimicry and a better understanding of the materials’ structure-dissolution behavior. This will contribute to “upgrade” our vision of entire cascades of events taking place at the implant surfaces upon immersion in the testing media or after implantation. Starting from an osteoinductive bioglass composition with the ability to alleviate the oxidative stress, thin bioglass films with different degrees of polymerization were deposited onto titanium substrates. Their biomineralization activity in simulated body fluid and in a series of new inorganic–organic media with increasing biomimicry that more closely simulated the human intercellular environment was compared. A comprehensive range of advanced characterization tools (scanning electron microscopy; grazing-incidence X-ray diffraction; Fourier-transform infrared, micro-Raman, energy-dispersive, X-ray photoelectron, and surface-enhanced laser desorption/ionization time-of-flight mass spectroscopies; and cytocompatibility assays using mesenchymal stem cells) were used. The information gathered is very useful to biologists, biophysicists, clinicians, and material scientists with special interest in teaching and research. By combining all the analyses, we propose herein a step forward toward establishing an improved unified protocol for testing the bioactivity of implant materials.

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“…This band is known to be highly sensitive to both short-range order and compositional changes occurring in the vicinity of the silicate tetrahedra environment [31]. This IR band position is distinctive for a vitreous silica-based structure deposited by magnetron sputtering [35,36]. The supplemental bands peaking for both source material and thin film in the ≈2800 to 3100 cm −1 region appertain to various stretching vibrations of C-H bonds [37], and suggest the presence of ordinary carbonaceous residues on the samples' surface as result of measurement, handling, and/or storage in normal ambient conditions [38].…”

Section: Resultsmentioning

confidence: 99%

Preparations of Silver/Montmorillonite Biocomposite Multilayers and Their Antifungal Activity

et al. 2019

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In this study, the results about the influence of the surface morphology of layers based on montmorillonite (MMT) and silver (Ag) on antimicrobial properties are reported. The coating depositions were performed in the plasma of a radio frequency (RF) magnetron sputtering discharge. The studied layers were single montmorillonite layers (MMT) and silver/montmorillonite multilayers (MMT-Ag) obtained by magnetron sputtering technique with a different surface thickness. The resultant MMT-Ag biocomposite multilayers exhibited a uniform distribution of constituent elements and enhanced antimicrobial properties against fungal biofilm development. Glow-discharge optical emission spectroscopy (GDOES) analysis revealed the formation of MMT-Ag biocomposite multilayers following the deposit of a silver layer for an MMT layer that was initially deposited on a Si substrate. The surface morphology and thickness evaluation of deposited biocomposite layers were performed by scanning electron microscopy (SEM). A qualitative analysis of the chemical composition of thin layers was performed and the elements O, Ag, Mg, Fe, Al, and Si were identified in the MMT-Ag biocomposite multilayers. The in vitro antifungal assay proved that the inhibitory effect against the growth of Candida albicans ATCC 101231 CFU was more emphasized in the case of MMT-Ag biocomposite multilayers that in the case of the MMT layer. Cytotoxicity studies performed on HeLa cells showed that the tested layers did not show significant toxicity at the time intervals during which the assay was performed. On the other hand, it was observed that the MMT layers exhibited slightly higher biocompatible properties than the MMT-Ag composite layers.

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Submicrometer Hollow Bioglass Cones Deposited by Radio Frequency Magnetron Sputtering: Formation Mechanism, Properties, and Prospective Biomedical Applications

Cited by 26 publications

References 70 publications

Mechanical, Corrosion and Biological Properties of Room-Temperature Sputtered Aluminum Nitride Films with Dissimilar Nanostructure

Mechanical, Corrosion and Biological Properties of Room-Temperature Sputtered Aluminum Nitride Films with Dissimilar Nanostructure

Bioglass implant-coating interactions in synthetic physiological fluids with varying degrees of biomimicry

Preparations of Silver/Montmorillonite Biocomposite Multilayers and Their Antifungal Activity

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