Submicron Emulsion Vehicle for Enhanced Transdermal Delivery of Steroidal and Nonsteroidal Antiinflammatory Drugs

Friedman, Doron; Schwarz, Joseph S.; Weisspapir, Michael

doi:10.1002/jps.2600840312

Cited by 68 publications

(15 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The present results are in contrast to what has been reported in other publications [6][7][8][9] . It should be taken into account that in most of the published work, comparison was made with emulsions from different system components and different compositions due to the difficulty to obtain emulsions with the same composition and different droplet sizes with enough stability.…”

Section: Discussioncontrasting

confidence: 57%

See 1 more Smart Citation

A Study on the Influence of Emulsion Droplet Size on the Skin Penetration of Tetracaine

Izquierdo

Wiechers²,

Escribano³

et al. 2007

Skin Pharmacol Physiol

View full text Add to dashboard Cite

Objectives/Aims: The influence of emulsion droplet size on the skin penetration of a model drug, tetracaine, was studied. For this purpose, in vitro dermal and transdermal delivery of tetracaine from 6 emulsions (3 macro-emulsions with droplet sizes >1 µm and 3 nano-emulsions with droplet sizes <100 nm) were tested. Methods: Two approaches were used: in the first one, the composition of the emulsions was kept constant, while in the second one, the surfactant concentration in the aqueous phase was kept constant by varying the overall surfactant concentration. Results: The results from emulsions differing only in droplet size did not provide statistically significant evidence for the anticipated increase in transdermal or dermal delivery (after 24 h) when reducing emulsion droplet size. The same results were obtained when the surfactant concentration in the aqueous phase was kept constant, indicating that there is no influence of emulsion droplet size on the skin penetration of tetracaine within the droplet size range studied. Conclusion: This is in contrast to what has been reported in various publications that claim penetration to increase with reducing droplet size. It should be noted that the results reported so far are based on emulsions that apart from droplet size also differed in composition and/or system components.

show abstract

Section: Discussioncontrasting

confidence: 57%

“…It has been reported that the anti-inflammatory activity of steroidal and non-steroidal drugs is higher for lipid submicron emulsions with droplet sizes in the range 40-200 nm than for emulsions with equal drug concentration but droplet sizes 1 5 m [6] . Diazepam penetration was found to be strongly enhanced by decreasing lipid emulsion droplet size to !…”

mentioning

confidence: 99%

A Study on the Influence of Emulsion Droplet Size on the Skin Penetration of Tetracaine

Izquierdo

Wiechers²,

Escribano³

et al. 2007

Skin Pharmacol Physiol

View full text Add to dashboard Cite

show abstract

“…Several studies have shown that the droplet size of delivery systems can play an important role in skin penetration of drugs. A decrease in the droplet diameter below 200 nm showed a significantly increase in skin penetration of several drugs (Friedman et al, 1995;Kreilgaard, 2002). Therefore, systems with small droplets such as microemulsions and submicron emulsions could be a more powerful tool for topical application and thus were not excluded from this study.…”

Section: Physicochemical Characterisation Of Delivery Systemsmentioning

confidence: 99%

Protective effect of drug delivery systems against the enzymatic degradation of dermally applied DNAzyme

Schmidts

Dobler

Hoff

et al. 2011

International Journal of Pharmaceutics

View full text Add to dashboard Cite

“…26 Submicron emulsions are oil-in-water emulsions with a droplet size below one micrometer. It is a kinetic stable emulsion in which the droplet size is achieved by an incorporation of emulsifiers.…”

Section: Drug Delivery System Preparationmentioning

confidence: 99%

Evaluation and quantification of spectral information in tissue by confocal microscopy

Maeder¹,

Marquardt²,

Beer³

et al. 2012

J. Biomed. Opt

View full text Add to dashboard Cite

Abstract. A confocal imaging and image processing scheme is introduced to visualize and evaluate the spatial distribution of spectral information in tissue. The image data are recorded using a confocal laser-scanning microscope equipped with a detection unit that provides high spectral resolution. The processing scheme is based on spectral data, is less error-prone than intensity-based visualization and evaluation methods, and provides quantitative information on the composition of the sample. The method is tested and validated in the context of the development of dermal drug delivery systems, introducing a quantitative uptake indicator to compare the performances of different delivery systems is introduced. A drug penetration study was performed in vitro. The results show that the method is able to detect, visualize and measure spectral information in tissue. In the penetration study, uptake efficiencies of different experiment setups could be discriminated and quantitatively described. The developed uptake indicator is a step towards a quantitative assessment and, in a more general view apart from pharmaceutical research, provides valuable information on tissue composition. It can potentially be used for clinical in vitro and in vivo applications.

show abstract

Submicron Emulsion Vehicle for Enhanced Transdermal Delivery of Steroidal and Nonsteroidal Antiinflammatory Drugs

Cited by 68 publications

References 6 publications

A Study on the Influence of Emulsion Droplet Size on the Skin Penetration of Tetracaine

A Study on the Influence of Emulsion Droplet Size on the Skin Penetration of Tetracaine

Protective effect of drug delivery systems against the enzymatic degradation of dermally applied DNAzyme

Evaluation and quantification of spectral information in tissue by confocal microscopy

Contact Info

Product

Resources

About