Submucosal nerve hypertrophy in congenital laryngomalacia

Abstract

The pathologic finding of nerve hypertrophy in children with laryngomalacia provides new evidence to support neurologic dysfunction as the etiologic theory of laryngomalacia.

Laryngomalacia: Review and Summary of Current Clinical Practice in 2015

“…This is supported by physiologic studies in infants with laryngomalacia demonstrating increased stimulus threshold requirements for elicitation of normal motor responses correlating with disease severity [4]. Additional corroboration is provided by histologic studies showing significant size differences in the superior laryngeal nerve branches of patients with severe laryngomalacia compared to age matched controls [8]. Subsequent neurological and central nervous system maturation would provide a reasonable explanation for the spontaneous resolution generally seen in the disease.…”

Oropharyngeal Dysphagia in Children

“…40 Increased diameter and surface area of the nerve endings have been reported in supra-arytenoid specimens harvested from laryngomalacia patients that may represent an autocrine enhancement of dysfunctional nervous system due to laryngomalacia. 41 Cervical and distal esophageal anatomic anomalies may also contribute to persistent OPD, including esophageal atresia, tracheoesophageal fistula (TEF), and cricopharyngeal achalasia.…”

Efektifitas Pemberian Proton Pump Inhibitor pada Bayi dan Anak dengan Laringomalasia

“…Belum ada studi prospektif yang menjelaskan berapa lama terapi acid supression pada anak. 11,16,[32][33][34] Menurut Thompson, 8 umumnya anak dengan laringomalasia membutuhkan terapi selama lebih kurang 9 bulan (1-38 bulan).…”