Subnanosecond probing of the ablation of soft plaque from arterial wall by 308 nm pulses delivered through a fiber

Srinivasan, R.; Casey, Kelly G.; Haller, Jordan D.

doi:10.1109/3.64365

Cited by 24 publications

(11 citation statements)

References 7 publications

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“…285,378,379 As a result, the potential for mechanical collateral damage is much larger than that for ablation in air. 24,26,78,207,292,293,378,[380][381][382][383][384][385][386][387][388] When the laser-induced stress transients possess a sufficiently short rise time, their propagation results in the formation of a shock wave. 387,389 The large pressure in the laser-induced vapor bubble leads to a very rapid expansion that overshoots the equilibrium state, in which the internal bubble pressure equals the hydrostatic pressure.…”

Section: B Amplification Of Mechanical Effects By Liquid Confinementmentioning

confidence: 99%

Mechanisms of Pulsed Laser Ablation of Biological Tissues

Vogel

Venugopalan

2003

ChemInform

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Section: B Amplification Of Mechanical Effects By Liquid Confinementmentioning

confidence: 99%

Mechanisms of Pulsed Laser Ablation of Biological Tissues

Vogel

Venugopalan

2003

ChemInform

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“…In contrast to earlier observations, in vitro [9][10][11][12] and in vivo [13,14] studies have demonstrated the explosive nature of tissue ablation by excimer laser pulses: Each ablative laser pulse absorbed by tissue or by blood will induce a rapidly expanding and imploding water vapor bubble (lifetime up to 300 s, diameter up to 3 mm) and stress waves. We demonstrated that within tissue, the explosive water vapor bubble expansion separates tissue layers [13].…”

Section: Introductionmentioning

confidence: 70%

Saline flush during excimer laser angioplasty: Short and long term effects in the rabbit femoral artery

et al. 1998

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Background and Objective: In this study, the effect of flushing saline on arterial wall damage (medial ruptures and necrosis), intimal hyperplasia, and arterial remodeling was determined. During excimer laser coronary angioplasty saline is flushed to reduce the size of explosive water vapor bubbles formed by intraluminal delivery of excimer laser pulses in blood. Methods In the femoral artery of the rabbit, 600 excimer laser pulses (308 nm, 50 mJ/mm2 per pulse, 20 Hz) were delivered coaxially over a length of 20 mm in 10 bursts of 3 seconds each. In 24/48 procedures, saline was flushed (0.2 ml/s) via the guidewire channel. After 2 and 56 days, microscopic and angiographic results were compared. Results At 2 days, as compared to lasing in blood, saline flush had drastically reduced the incidence of dissections (2/12 vs. 11/12, P < 0.002), but had increased the extent of medial and adventitial necrosis. The latter is attributed to direct irradiation of the arterial wall. After 56 days, in the saline group, in the middle‐distal part of treated segments, medial necrosis without intimal hyperplasia was observed. However, at the edges of these lesions, intimal hyperplasia and arterial shrinkage reduced the lumen. Conclusion Flushing saline during coaxial excimer laser pulse delivery significantly reduced the incidence of vessel wall ruptures, and prevented intimal hyperplasia formation in part of the lesion. The histologic findings at 56 days are attributed to the optical window which the saline flush provides for direct ultraviolet light irradiation of the arterial wall. Lasers Surg. Med. 23:128–140, 1998. © 1998 Wiley‐Liss, Inc.

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“…A recent investigation has reported on excimer laser ablation under atmospheric conditions using the ultrafast imaging technique [5]. According t o this study, we found that excimer laser ablation results in an explosive ejection of ablated tissue material in form of small particles.…”

Section: Histological Examinationmentioning

confidence: 75%

“…Since ablation has been observed even with short pulsed infrared lasers [71 where the photon energy is not sufficient to break chemical bonds, it is probable that two processes are responsible for the basic mechanism of ablation: bond breakage and water superheating [81. Despite the phenomenon leading to tissue ablation, it is well known that a rapid expansion of gaseous ablation products occurs during ablation, and results in an explosive removal of the irradiated material [6-81. Using the technique of ultrafast imaging, the temporal development and spatial distribution of the laser ablation has been visualized by several groups [5,. Recent studies [7,9] have reported on the results of noncontact tissue ablation by a mid-infrared holmium laser system performed in both saline and blood.…”

Section: Introduction Words: Atherosclerosis Excimer Laser Pulsed Lmentioning

confidence: 99%

“…Recent studies [7,9] have reported on the results of noncontact tissue ablation by a mid-infrared holmium laser system performed in both saline and blood. Several investigators have visualized excimer laser ablation using a fiber delivery system [5,101. However, all experiments dealing with excimer laser ablation were determined under atmospheric conditions.…”

Section: Introduction Words: Atherosclerosis Excimer Laser Pulsed Lmentioning

confidence: 99%

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Ultrafast imaging of tissue ablation by a XeCl excimer laser in saline

et al. 1992

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To determine the temporal evolution of laser induced tissue ablation, arterial wall specimens with either hard calcified or fatty plaques and normal tissue were irradiated in a 0.9% saline solution using a XeCl excimer laser (wavelength 308 nm, energy fluence 7 J/cm2, pulse width 30 ns) through a 600 microns fused silica fiber pointing perpendicular either at a 0.5 mm distance or in direct contact to the vascular surface. Radiation of a pulsed dye laser (wavelength 580 nm) was used to illuminate the tissue surface. The ablation process and the arising bubble above the tissue surface were recorded with a CCD camera attached to a computer based image-processing system. Spherical cavitation bubbles and small tissue particles emerging from the irradiated area have been recorded. The volume of this bubble increased faster for calcified plaques than for normal tissue.

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Subnanosecond probing of the ablation of soft plaque from arterial wall by 308 nm pulses delivered through a fiber

Cited by 24 publications

References 7 publications

Mechanisms of Pulsed Laser Ablation of Biological Tissues

Mechanisms of Pulsed Laser Ablation of Biological Tissues

Saline flush during excimer laser angioplasty: Short and long term effects in the rabbit femoral artery

Ultrafast imaging of tissue ablation by a XeCl excimer laser in saline

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