Subpallial origin of part of the calbindin-positive neurons of the claustral complex and piriform cortex

Legáz, Isabel; García-López, Margarita; Medina, Loreta

doi:10.1016/j.brainresbull.2005.05.006

Cited by 26 publications

(23 citation statements)

References 24 publications

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“…Finally, parvalbumin immunoreactivity started to be observed postnatally in neurons of the mouse claustral complex, similarly to the findings in the rodent cerebral cortex (Alcá ntara et al, 1996) and amygdala (Berdel and Morys, 2000). We will separately discuss our results for each calcium-binding protein in the different parts of the claustral complex (with the help of Cadherin 8, a specific gene marker of the developing dorsolateral claustrum) and compare the development of the neurons expressing these proteins with some data on their partial embryonic origin in the subpallium (Sussel et al, 1999;Legaz et al, 2004).…”

Section: Discussionsupporting

confidence: 61%

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Embryonic and postnatal development of GABA, calbindin, calretinin, and parvalbumin in the mouse claustral complex

et al. 2004

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We analyzed the development of immunoreactive expression patterns for the neurotransmitter gamma-aminobutyric acid (GABA) and the calcium-binding proteins calbindin, calretinin, and parvalbumin in the embryonic and postnatal mouse claustral complex. Each calcium-binding protein shows a different temporal and spatial pattern of development. Calbindin-positive cells start to be seen very early during embryogenesis and increase dramatically until birth, thus becoming the most abundant cell type during embryonic development, especially in the ventral pallial part of the claustrum. The distribution of calbindin neurons throughout the claustrum during embryonic development partly parallels that of GABA neurons, suggesting that at least part of the calbindin neurons of the claustral complex are GABAergic and originate in the subpallium. Parvalbumin cells, on the other hand, start to be seen only postnatally, and their number then increases while the density of calbindin neurons decreases. Based on calretinin expression in axons, the core/shell compartments of the dorsal claustrum start to be clearly seen at embryonic day 18.5 and may be related to the development of the thalamoclaustral input. Comparison with the expression of Cadherin 8, a marker of the developing dorsolateral claustrum, indicates that the core includes a central part of the dorsolateral claustrum, whereas the shell includes a peripheral area of the dorsolateral claustrum, plus the adjacent ventromedial claustrum. The present data on the spatiotemporal developmental patterns of several subtypes of GABAergic neurons in the claustral complex may help for future studies on temporal lobe epilepsies, which have been related to an alteration of the GABAergic activity.

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Section: Discussionsupporting

confidence: 61%

“…Calbindin-immunoreactive (CBϩ) neurons were first observed very early in the development in the mouse claustrum (E13.5-E14.5; Legaz et al, 2004;present results). The abundance of CBϩ neurons in the claustral complex (as well as in the superficial piriform cortex) dramatically increased throughout embryonic development.…”

Section: Gaba and Calbindinmentioning

confidence: 78%

Embryonic and postnatal development of GABA, calbindin, calretinin, and parvalbumin in the mouse claustral complex

et al. 2004

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“…6,7;Tables 1C,2). In addition to the strong Lhx6 expression in the pallido-septo-AEP-POC territory, this gene is also expressed in immature interneurons that emigrate tangentially into the striatum and pallium/ cerebral cortex (including the claustrum and pallial amygdala; Marín et al, 2000;Alifragis et al, 2004;Legaz et al, 2005b) …”

Section: Resultsmentioning

confidence: 99%

Histogenetic compartments of the mouse centromedial and extended amygdala based on gene expression patterns during development

García-López

Abellán

Legáz

et al. 2007

J of Comparative Neurology

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The amygdala controls emotional and social behavior and regulates instinctive reflexes such as defense and reproduction by way of descending projections to the hypothalamus and brainstem. The descending amygdalar projections are suggested to show a cortico-striato-pallidal organization similar to that of the basal ganglia (Swanson [2000] Brain Res 886:113-164). To test this model we investigated the embryological origin and molecular properties of the mouse centromedial and extended amygdalar subdivisions, which constitute major sources of descending projections. We analyzed the distribution of key regulatory genes that show restricted expression patterns within the subpallium (Dlx5, Nkx2.1, Lhx6, Lhx7/8, Lhx9, Shh, and Gbx1), as well as genes considered markers for specific subpallial neuronal subpopulations. Our results indicate that most of the centromedial and extended amygdala is formed by cells derived from multiple subpallial subdivisions. Contrary to a previous suggestion, only the central--but not the medial--amygdala derives from the lateral ganglionic eminence and has striatal-like features. The medial amygdala and a large part of the extended amygdala (including the bed nucleus of the stria terminalis) consist of subdivisions or cell groups that derive from subpallial, pallial (ventral pallium), or extratelencephalic progenitor domains. The subpallial part includes derivatives from the medial ganglionic eminence, the anterior peduncular area, and possibly a novel subdivision, called here commissural preoptic area, located at the base of the septum and related to the anterior commissure. Our study provides a molecular and morphological foundation for understanding the complex embryonic origins and adult organization of the centromedial and extended amygdala.

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“…In particular, the MeA possesses abundant GABAergic cells throughout development in a manner that strengthens the subpallial origin of this region. Conversely, adjacent zones like the LA and other pallial regions contain GABAergic cells that are scattered and separated from the ventricle from the first moment that they are observed, suggesting that they have migrated from subpallial territories following a tangential path, as in mammals (Marín and Rubenstein, 2003;Legaz et al, 2005b).…”

Section: The Mea In Anurans: Comparison With Other Vertebrates and Evmentioning

confidence: 90%

Development of the vomeronasal amygdala in anuran amphibians: Hodological, neurochemical, and gene expression characterization

Moreno

González

2007

J of Comparative Neurology

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The organization of the amygdaloid complex in amphibians possesses major features shared with amniotes. Basic subdivisions have been identified and tentatively compared with their counterparts in other tetrapods. However, problems appeared when trying to find homologies for the amphibian vomeronasal amygdala, the medial amygdala (MeA), because of its embryological origin and, therefore, its evolutionary significance could not be established. Thus, in the present study the main characteristics of the MeA in anurans were studied during development by means of tract-tracing, immunohistochemical, and gene expression techniques. The connectivity of the MeA, mainly related to the accessory olfactory bulb and the hypothalamus, and the localization of neurochemical markers such as substance P, somatostatin, and GABA strongly support its homology with the medial amygdala (subpallial) of mammals. In addition, analysis of the expression patterns of the LIM-homeodomain genes x-Lhx5/7/9 in the developing MeA, together with the immunohistochemistry for GABA and the transcription factor NKX2.1, evidence its resemblance to the subpallial component of the vomeronasal amygdala of mammals in terms of embryological origin and, most likely, the presence of migrated cells from other territories. No evidence was found for pallial-derived territories in the vomeronasal amygdala of anurans that could be comparable to the cortical portions that exist in amniotes, suggesting that these cortical components have emerged in the anamnio-amniotic transition in the evolution of tetrapods.

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Subpallial origin of part of the calbindin-positive neurons of the claustral complex and piriform cortex

Cited by 26 publications

References 24 publications

Embryonic and postnatal development of GABA, calbindin, calretinin, and parvalbumin in the mouse claustral complex

Embryonic and postnatal development of GABA, calbindin, calretinin, and parvalbumin in the mouse claustral complex

Histogenetic compartments of the mouse centromedial and extended amygdala based on gene expression patterns during development

Development of the vomeronasal amygdala in anuran amphibians: Hodological, neurochemical, and gene expression characterization

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